Neuroimaging Findings in a Patient with Anti-IgLON5 Disease: Cerebrospinal Fluid Dynamics Abnormalities.
Daniele Urso, Roberto De Blasi, Antonio Anastasia, Valentina Gnoni, Valentina Rizzo, Salvatore Nigro, Benedetta Tafuri, Carlo Maria Iacolucci, Chiara Zecca, Maria Teresa Dell'Abate, Francesca Andreetta, Giancarlo Logroscino
Author Information
Daniele Urso: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy. ORCID
Roberto De Blasi: Department of Diagnostic Imaging, Pia Fondazione di Culto e Religione "Card. G. Panico", 73039 Tricase, Italy.
Antonio Anastasia: Department of Diagnostic Imaging, Pia Fondazione di Culto e Religione "Card. G. Panico", 73039 Tricase, Italy.
Valentina Gnoni: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy.
Valentina Rizzo: Department of Diagnostic Imaging, Pia Fondazione di Culto e Religione "Card. G. Panico", 73039 Tricase, Italy.
Salvatore Nigro: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy. ORCID
Benedetta Tafuri: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy. ORCID
Carlo Maria Iacolucci: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy.
Chiara Zecca: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy.
Maria Teresa Dell'Abate: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy.
Francesca Andreetta: Neurology IV-Neuroimmunology and Neuromuscular Disease Unit, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Giancarlo Logroscino: Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", 73039 Tricase, Italy.
Anti-IgLON5 disease is a recently described autoimmune neurodegenerative disorder characterized by insidious onset, slow progression and a variety of neurological features. Neuroimaging in most patients with anti-IgLON5 disease is normal or shows nonspecific findings. Here, we report a case of anti-IgLON5 disease presenting with parkinsonism, falls, sleep problems with severe nocturnal dyspnea attacks, dysphagia, and dysautonomia. Imaging findings were initially suggestive of progressive supranuclear palsy. An altered cerebrospinal fluid dynamic was found on an MRI as well as high-convexity hyperperfusion on a brain SPECT. Further case descriptions with neuroimaging are required to characterize cerebral and cerebrospinal fluid dynamics abnormalities in this rare condition.
