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Phytotherapy research : PTR
Jul, 2022;36 (7): 2779-2802.

Hyperoside: A review on its sources, biological activities, and molecular mechanisms.

Qi Wang, Hao-Cheng Wei, Sheng-Jun Zhou, Ying Li, Ting-Ting Zheng, Chang-Zheng Zhou, Xin-Huan Wan
Author Information
  1. Qi Wang: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China.
  2. Hao-Cheng Wei: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China.
  3. Sheng-Jun Zhou: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China.
  4. Ying Li: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China.
  5. Ting-Ting Zheng: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China.
  6. Chang-Zheng Zhou: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China. ORCID
  7. Xin-Huan Wan: College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, China.
PMID: 35561084 DOI: 10.1002/ptr.7478

Abstract

Hyperoside is a natural flavonol glycoside in various plants, such as Crataegus pinnatifida Bge, Forsythia suspensa, and Cuscuta chinensis Lam. Medical research has found that hyperoside possesses a broad spectrum of biological activities, including anticancer, anti-inflammatory, antibacterial, antiviral, antidepressant, and organ protective effects. These pharmacological properties lay the foundation for its use in treating multiple diseases, such as sepsis, arthritis, colitis, diabetic nephropathy, myocardial ischemia-reperfusion, pulmonary fibrosis, and cancers. Hyperoside is obtained from the plants and chemical synthesis. This study aims to provide a comprehensive overview of hyperoside on its sources and biological activities to provide insights into its therapeutic potential, and to provide a basis for high-quality studies to determine the clinical efficacy of this compound.

Keywords

biological activities extraction hyperoside synthesis

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Grants

  1. ZR2020MB108/Shandong Provincial Natural Science Foundation
  2. ZR2021QH232/Shandong Provincial Natural Science Foundation

MeSH Term

Anti-Inflammatory Agents
Crataegus
Plant Extracts
Quercetin

Chemicals

Anti-Inflammatory Agents
Plant Extracts
hyperoside
Quercetin
Journal Article Review

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