OpenLB
Open Library of Bioscience
Advanced Search
Frontiers in pharmacology
2022;13 909504.

Nanodrugs Detonate Lysosome Bombs.

Yuting Xiang, Niansheng Li, Min Liu, Qiaohui Chen, Xingyu Long, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Xiaoyuan Wang, Yunrong Yang, Jinping Zhang, Chong Liu, Qiong Huang
Author Information
  1. Yuting Xiang: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  2. Niansheng Li: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  3. Min Liu: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  4. Qiaohui Chen: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  5. Xingyu Long: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  6. Yuqi Yang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  7. Zuoxiu Xiao: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  8. Jia Huang: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  9. Xiaoyuan Wang: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  10. Yunrong Yang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  11. Jinping Zhang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  12. Chong Liu: Departments of Clinical Pharmacology and Pharmacy, Hunan Key Laboratory of Pharmacogenetics, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  13. Qiong Huang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
PMID: 35656308 DOI: 10.3389/fphar.2022.909504

Abstract

Cancer cell lysosomes contain various hydrolases and non-degraded substrates that are corrosive enough to destroy cancer cells. However, many traditional small molecule drugs targeting lysosomes have strong side effects because they cannot effectively differentiate between normal and cancer cells. Most lysosome-based research has focused on inducing mild lysosomal membrane permeabilization (LMP) to release anticancer drugs from lysosomal traps into the cancer cell cytoplasm. In fact, lysosomes are particularly powerful "bombs". Achieving cancer cell-selective LMP induction may yield high-efficiency anticancer effects and extremely low side effects. Nanodrugs have diverse and combinable properties and can be specifically designed to selectively induce LMP in cancer cells by taking advantage of the differences between cancer cells and normal cells. Although nanodrugs-induced LMP has made great progress recently, related reviews remain rare. Herein, we first comprehensively summarize the advances in nanodrugs-induced LMP. Next, we describe the different nanodrugs-induced LMP strategies, namely nanoparticles aggregation-induced LMP, chemodynamic therapy (CDT)-induced LMP, and magnetic field-induced LMP. Finally, we analyze the prospect of nanodrugs-induced LMP and the challenges to overcome. We believe this review provides a unique perspective and inspiration for designing lysosome-targeting drugs.

Keywords

cancer treatment chemodynamic therapy lysosomal membrane permeabilization magnetic nanoparticles nanodrugs nanomaterials subcellular organelle-targeting

References

Angew Chem Int Ed Engl. 2019 Jan 21;58(4):946-956 [PMID: 30048028]
Small. 2022 Feb;18(6):e2103868 [PMID: 34729913]
Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9562-9572 [PMID: 33590957]
Cancer Res. 2005 Jun 15;65(12):5190-4 [PMID: 15958563]
Biochim Biophys Acta. 2009 Apr;1793(4):746-54 [PMID: 18948147]
ACS Biomater Sci Eng. 2020 Sep 14;6(9):4799-4815 [PMID: 33455213]
Cancers (Basel). 2019 Nov 26;11(12): [PMID: 31779223]
Nat Nanotechnol. 2020 Apr;15(4):331-341 [PMID: 32203435]
J Am Chem Soc. 2016 Dec 14;138(49):16046-16055 [PMID: 27960313]
Redox Biol. 2021 Sep;45:102046 [PMID: 34174559]
ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29037-29055 [PMID: 32459082]
J Control Release. 2018 Jan 28;270:120-134 [PMID: 29203413]
Oncol Rep. 2017 Jun;37(6):3175-3180 [PMID: 28440429]
Histochem Cell Biol. 2008 Apr;129(4):389-406 [PMID: 18259769]
ACS Appl Mater Interfaces. 2020 Sep 9;12(36):40673-40683 [PMID: 32786245]
Bioact Mater. 2021 Apr 27;6(11):4209-4242 [PMID: 33997503]
Part Fibre Toxicol. 2012 Jun 14;9:20 [PMID: 22697169]
Mater Today Bio. 2019 Nov 06;5:100035 [PMID: 32211603]
Biomaterials. 2016 Apr;85:152-67 [PMID: 26871891]
Mitochondrion. 2014 Nov;19 Pt A:49-57 [PMID: 24984038]
J Nanobiotechnology. 2019 Jun 13;17(1):75 [PMID: 31196217]
Nat Cell Biol. 2017 Sep;19(9):1116-1129 [PMID: 28846096]
Ann N Y Acad Sci. 2016 May;1371(1):45-54 [PMID: 26599426]
Biosens Bioelectron. 2017 Jun 15;92:724-732 [PMID: 27825878]
Bioact Mater. 2021 Jun 20;7:47-72 [PMID: 34466716]
Angew Chem Int Ed Engl. 2021 Dec 20;60(52):26994-27004 [PMID: 34643312]
Theranostics. 2015 Sep 01;5(11):1249-63 [PMID: 26379790]
CA Cancer J Clin. 2021 May;71(3):209-249 [PMID: 33538338]
Biomaterials. 2021 Oct;277:121078 [PMID: 34461458]
Adv Healthc Mater. 2022 Jan;11(1):e2101346 [PMID: 34624168]
Adv Mater. 2022 Jan;34(1):e2104704 [PMID: 34632634]
Front Pharmacol. 2022 Feb 18;13:844037 [PMID: 35250594]
Cell Mol Life Sci. 2018 Jan;75(2):193-208 [PMID: 28733901]
Nanoscale Adv. 2021 Nov 18;4(2):421-436 [PMID: 36132704]
Nat Commun. 2020 Sep 15;11(1):4615 [PMID: 32934241]
Annu Rev Physiol. 1966;28:435-92 [PMID: 5322983]
Adv Sci (Weinh). 2021 Nov;8(22):e2102666 [PMID: 34523247]
Nat Commun. 2018 Jul 31;9(1):2997 [PMID: 30065243]
Front Cell Dev Biol. 2021 May 13;9:635104 [PMID: 34055771]
Biochem Soc Trans. 2018 Apr 17;46(2):207-215 [PMID: 29472365]
J Cell Sci. 2005 May 1;118(Pt 9):1991-2003 [PMID: 15840653]
Nat Rev Drug Discov. 2018 Feb;17(2):133-150 [PMID: 29147032]
Nat Rev Cancer. 2005 Nov;5(11):886-97 [PMID: 16239905]
Adv Drug Deliv Rev. 2020;163-164:65-83 [PMID: 32603814]
Front Pharmacol. 2022 Jan 10;13:847048 [PMID: 35222052]
Mater Today Bio. 2022 Feb 08;13:100215 [PMID: 35198963]
Mater Today Bio. 2022 Feb 15;13:100218 [PMID: 35243293]
Cell Death Differ. 2018 Mar;25(3):486-541 [PMID: 29362479]
J Am Chem Soc. 2019 Jun 26;141(25):9937-9945 [PMID: 31199131]
Drug Resist Updat. 2016 Jan;24:23-33 [PMID: 26830313]
Chem Sci. 2017 Nov 1;8(11):7675-7681 [PMID: 29568430]
Acta Pharm Sin B. 2020 Dec;10(12):2374-2383 [PMID: 33354508]
Apoptosis. 2000 Feb;5(1):17-20 [PMID: 11227486]
Journal Article Review

Word Cloud

Similar Articles

Cited By