OpenLB
Open Library of Bioscience
Advanced Search
The European respiratory journal
01, 2023;61 (1):

Living without eosinophils: evidence from mouse and man.

David J Jackson, Ian D Pavord
Author Information
  1. David J Jackson: Guy's Severe Asthma Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK David.Jackson@gstt.nhs.uk.
  2. Ian D Pavord: Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, University of Oxford, Oxford, UK.
PMID: 35953100 DOI: 10.1183/13993003.01217-2022

Abstract

The enduring view of eosinophils, as immune effector cells whose primary function is host defence against infection by helminths and other microbial pathogens, sets the stage for a fundamental question regarding the safety of therapeutic eosinophil depletion. If eosinophils are significantly reduced or altogether depleted in an effort to alleviate the negative effects of tissue eosinophilia and eosinophilic inflammation in conditions such as asthma, COPD, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome, would these patients become susceptible to infection or another illness? Development of mouse models in which the eosinophil lineage has been ablated, observations in patients naturally lacking eosinophils and data from studies of eosinophil-depleting medical therapies indicate that the absence of eosinophils is not detrimental to health. The evidence available to date, as presented in this review, supports the conclusion that even if certain homeostatic roles for the eosinophil may be demonstrable in controlled animal models and human settings, the evolution of the human species appears to have provided sufficient immune redundancy such that one may be hale and hearty without eosinophils.

References

J Allergy Clin Immunol Pract. 2021 Dec;9(12):4381-4392.e4 [PMID: 34487870]
Allergy Asthma Immunol Res. 2010 Apr;2(2):87-101 [PMID: 20358022]
Am J Respir Cell Mol Biol. 2016 Sep;55(3):387-94 [PMID: 27049514]
Curr Opin Infect Dis. 2012 Aug;25(4):458-63 [PMID: 22691685]
J Allergy Clin Immunol. 2019 May;143(5):1742-1751.e7 [PMID: 30359681]
Allergy. 2022 Aug;77(8):2558-2560 [PMID: 35491441]
Front Med (Lausanne). 2017 Jul 11;4:101 [PMID: 28744457]
J Asthma Allergy. 2019 Dec 09;12:401-413 [PMID: 31849500]
J Allergy Clin Immunol. 2020 Dec;146(6):1397-1405 [PMID: 32956756]
J Immunol. 2009 Feb 1;182(3):1577-83 [PMID: 19155506]
J Diabetes Complications. 2019 Aug;33(8):535-538 [PMID: 31204245]
J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1572-1581.e3 [PMID: 29122156]
Allergy. 2019 Oct;74(10):1898-1909 [PMID: 30934128]
Am J Respir Crit Care Med. 2011 Nov 15;184(10):1125-32 [PMID: 21852542]
Immunology. 2019 Nov;158(3):194-205 [PMID: 31433857]
J Immunol. 2012 Jan 1;188(1):417-25 [PMID: 22131328]
Cancer Immunol Res. 2014 Jan;2(1):1-8 [PMID: 24778159]
J Clin Invest. 2016 Sep 1;126(9):3279-95 [PMID: 27548519]
Mucosal Immunol. 2015 May;8(3):672-82 [PMID: 25336167]
N Engl J Med. 2019 Sep 12;381(11):1023-1034 [PMID: 31112385]
Infection. 2015 Dec;43(6):691-8 [PMID: 26008854]
ERJ Open Res. 2020 Nov 10;6(4): [PMID: 33263051]
Clin Exp Allergy. 2018 Jun;48(6):691-702 [PMID: 29473965]
Immunity. 2014 Apr 17;40(4):582-93 [PMID: 24745334]
J Exp Med. 2018 Aug 6;215(8):2055-2072 [PMID: 29970473]
J Asthma. 2019 Aug;56(8):808-815 [PMID: 30130418]
Cancer Res. 2015 Apr 15;75(8):1624-1634 [PMID: 25691457]
Annu Rev Immunol. 2021 Apr 26;39:719-757 [PMID: 33646859]
Allergy. 2021 Sep;76(9):2913-2916 [PMID: 34028047]
J Immunol. 2007 Apr 1;178(7):4222-9 [PMID: 17371978]
Nat Rev Dis Primers. 2020 Oct 29;6(1):86 [PMID: 33122665]
Mucosal Immunol. 2015 Jul;8(4):930-42 [PMID: 25563499]
Rheum Dis Clin North Am. 2016 Feb;42(1):157-76, ix-x [PMID: 26611557]
J Allergy Clin Immunol. 2013 Feb;131(2):461-7.e1-5 [PMID: 23040887]
Thorax. 2015 Sep;70(9):854-61 [PMID: 26108570]
Chest. 2021 Feb;159(2):496-506 [PMID: 32882249]
J Investig Allergol Clin Immunol. 2021 Apr 20;31(2):94-107 [PMID: 32540792]
Am J Respir Crit Care Med. 2019 Feb 15;199(4):508-517 [PMID: 30192638]
Clin Respir J. 2019 Mar;13(3):189-191 [PMID: 30666793]
Respir Res. 2021 Jun 7;22(1):173 [PMID: 34098934]
N Engl J Med. 2014 Sep 25;371(13):1198-207 [PMID: 25199059]
Infect Immun. 2019 Sep 19;87(10): [PMID: 31285249]
Allergy. 2013 Jul;68(7):829-35 [PMID: 23742015]
Drug Saf. 2020 May;43(5):409-425 [PMID: 32242310]
Am J Respir Crit Care Med. 2010 Nov 15;182(10):1273-81 [PMID: 20595227]
J Allergy Clin Immunol. 2020 Jul;146(1):1-7 [PMID: 32344056]
Am J Respir Crit Care Med. 2014 Dec 15;190(12):1373-82 [PMID: 25350863]
Laryngoscope. 2019 Feb;129(2):E61-E66 [PMID: 30284267]
J Immunol. 2017 Jul 15;199(2):624-632 [PMID: 28566368]
J Allergy Clin Immunol Pract. 2021 Sep;9(9):3529-3531.e1 [PMID: 34273579]
J Exp Med. 2002 Jun 3;195(11):1387-95 [PMID: 12045237]
Parasitology. 2017 Mar;144(3):295-315 [PMID: 26905057]
Lancet Respir Med. 2020 May;8(5):461-474 [PMID: 32066536]
Nat Rev Cancer. 2020 Oct;20(10):594-607 [PMID: 32678342]
J Clin Invest. 2018 Mar 1;128(3):997-1009 [PMID: 29400693]
Clin Ther. 2019 Oct;41(10):2041-2056.e5 [PMID: 31447130]
Lancet Respir Med. 2021 Oct;9(10):1141-1153 [PMID: 33872587]
Cell. 2014 Jun 5;157(6):1292-1308 [PMID: 24906148]
Rev Endocr Metab Disord. 2018 Dec;19(4):283-292 [PMID: 29922964]
Blood. 2018 Aug 2;132(5):501-509 [PMID: 29739754]
J Investig Allergol Clin Immunol. 2018;28(5):289-304 [PMID: 30059011]
J Asthma. 2021 Apr;58(4):514-522 [PMID: 31859541]
J Leukoc Biol. 2018 Jul;104(1):49-60 [PMID: 29522237]
J Allergy Clin Immunol Pract. 2021 Jan;9(1):481-483.e2 [PMID: 33039646]
Immunol Cell Biol. 2021 Jan;99(1):13-16 [PMID: 33167058]
J Allergy Clin Immunol Pract. 2021 Mar;9(3):1405-1407.e3 [PMID: 33316460]
Lancet Respir Med. 2019 Jan;7(1):46-59 [PMID: 30416083]
Science. 2004 Sep 17;305(5691):1773-6 [PMID: 15375267]
Annu Rev Pathol. 2020 Jan 24;15:179-209 [PMID: 31977298]
Blood. 2006 Oct 1;108(7):2420-7 [PMID: 16772607]
Lancet. 2012 Aug 18;380(9842):651-9 [PMID: 22901886]
Lancet Respir Med. 2015 May;3(5):355-66 [PMID: 25736990]
Int J Parasitol. 2007 Oct;37(12):1367-78 [PMID: 17555758]
Allergy. 2022 Sep;77(9):2822-2825 [PMID: 35524429]
J Allergy Clin Immunol. 2012 Sep;130(3):572-84 [PMID: 22935586]
Eur J Immunol. 2020 Jul;50(7):1044-1056 [PMID: 32108934]
J Allergy Clin Immunol. 2022 Apr;149(4):1309-1317.e12 [PMID: 34599979]
J Allergy Clin Immunol. 1994 Dec;94(6 Pt 2):1202-13 [PMID: 7798561]
Curr Med Chem. 2016;23(7):650-66 [PMID: 26785997]
Parasite Immunol. 2021 Mar;43(3):e12791 [PMID: 32918307]
Clin Ther. 2016 Sep;38(9):2058-2070.e1 [PMID: 27553751]
J Allergy Clin Immunol Pract. 2022 Jun;10(6):1598-1605.e2 [PMID: 35283330]
Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12355-8 [PMID: 8901585]
Lancet. 2016 Oct 29;388(10056):2115-2127 [PMID: 27609408]
Genes Dev. 1995 May 15;9(10):1250-62 [PMID: 7758949]
Infect Immun. 2011 Jul;79(7):2770-8 [PMID: 21482685]
J Allergy Clin Immunol. 2021 Aug;148(2):361-367.e13 [PMID: 34144110]
Science. 2011 Apr 8;332(6026):243-7 [PMID: 21436399]
N Engl J Med. 2017 May 18;376(20):1921-1932 [PMID: 28514601]
N Engl J Med. 2021 Dec 9;385(24):2230-2240 [PMID: 34879449]
Infect Immun. 2014 Aug;82(8):3199-205 [PMID: 24842927]
J Allergy Clin Immunol Pract. 2021 Sep;9(9):3531-3532 [PMID: 34273580]
Allergy. 2021 Jun;76(6):1890-1893 [PMID: 33300186]
Lancet Respir Med. 2014 Nov;2(11):891-901 [PMID: 25208464]
Microorganisms. 2020 Nov 17;8(11): [PMID: 33212993]
Trends Parasitol. 2016 Oct;32(10):798-807 [PMID: 27262918]
Lancet Respir Med. 2017 Jul;5(7):568-576 [PMID: 28545978]
Nat Metab. 2020 Aug;2(8):688-702 [PMID: 32694825]
Lancet. 2016 Oct 29;388(10056):2128-2141 [PMID: 27609406]
Br J Haematol. 2008 Dec;143(5):707-15 [PMID: 18950453]
Blood Cells Mol Dis. 2017 Mar;63:62-65 [PMID: 28178599]
Int J Mol Sci. 2021 Jul 27;22(15): [PMID: 34360770]
J Exp Med. 2008 Jun 9;205(6):1285-92 [PMID: 18490489]
Lancet Respir Med. 2017 Sep;5(9):747-759 [PMID: 28601554]
N Engl J Med. 2019 Apr 4;380(14):1336-1346 [PMID: 30943337]
J Allergy Clin Immunol. 2013 Nov;132(5):1086-1096.e5 [PMID: 23866823]
Nat Rev Immunol. 2011 Jun;11(6):375-88 [PMID: 21610741]
N Engl J Med. 2017 Oct 26;377(17):1613-1629 [PMID: 28893134]
Allergy. 2021 Feb;76(2):471-482 [PMID: 32562554]
J Immunol. 2015 Jan 1;194(1):283-90 [PMID: 25429065]
Am J Respir Crit Care Med. 2020 Nov 1;202(9):1314-1316 [PMID: 32584603]
Parasit Vectors. 2019 May 20;12(1):248 [PMID: 31109364]
Immune Netw. 2020 Jun 23;20(3):e24 [PMID: 32655972]
PLoS Pathog. 2014 Mar 13;10(3):e1003988 [PMID: 24626328]
Curr Opin Immunol. 2020 Oct;66:151-160 [PMID: 33212388]

MeSH Term

Animals
Humans
Eosinophils
Rhinitis
Churg-Strauss Syndrome
Granulomatosis with Polyangiitis
Eosinophilia
Nasal Polyps
Journal Article Review Research Support, Non-U.S. Gov't

Word Cloud

Similar Articles

Cited By