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Cancer science
Dec, 2022;113 (12): 4030-4036.

Carcinogenesis resistance in the longest-lived rodent, the naked mole-rat.

Yuki Yamamura, Yoshimi Kawamura, Kaori Oka, Kyoko Miura
Author Information
  1. Yuki Yamamura: Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. ORCID
  2. Yoshimi Kawamura: Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. ORCID
  3. Kaori Oka: Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. ORCID
  4. Kyoko Miura: Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. ORCID
PMID: 36083242 DOI: 10.1111/cas.15570

Abstract

Certain mammalian species are resistant to cancer, and a better understanding of how this cancer resistance arises could provide valuable insights for basic cancer research. Recent technological innovations in molecular biology have allowed the study of cancer-resistant mammals, despite the fact that they are not the classical model animals, which are easily studied using genetic approaches. Naked mole-rats (NMRs; Heterocephalus glaber) are the longest-lived rodent, with a maximum lifespan of more than 37 years, and almost never show spontaneous carcinogenesis. NMRs are currently attracting much attention from aging and cancer researchers, and published studies on NMR have continued to increase over the past decade. Cancer development occurs via multiple steps and involves many biological processes. Recent research on the NMR as a model for cancer resistance suggests that they possess various unique carcinogenesis-resistance mechanisms, including efficient DNA repair pathways, cell-autonomous resistance to transformation, and dampened inflammatory response. Here, we summarize the molecular mechanisms of carcinogenesis resistance in NMR, which have been uncovered over the past two decades, and discuss future perspectives.

Keywords

DNA repair cancer inflammation naked mole-rat transformation

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Grants

  1. JPMJFR216C/Japan Science and Technology Agency
  2. JP22K15024/Japan Society for the Promotion of Science
  3. JP22K06069/Japan Society for the Promotion of Science
  4. JP21H05143/Japan Society for the Promotion of Science
  5. JP21H02392/Japan Society for the Promotion of Science
  6. JP22K18355/Japan Society for the Promotion of Science

MeSH Term

Animals
Mole Rats
Longevity
Aging
Neoplasms
Biological Phenomena
Journal Article Review

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