PURPOSE: We used a within-subject, cross-over study to determine the relationship between the intra-individual adaptations to four weeks' resistance (RT) versus four weeks' endurance (END) training, and we investigated whether three single nucleotide polymorphisms (SNPs) were associated with these adaptations.
METHODS: Thirty untrained, healthy, young men completed a cycling test to exhaustion to determine peak oxygen uptake (V̇O), and a knee extension (KE) maximum voluntary isometric contraction (MVIC) of the right leg before and after four weeks' supervised RT (four sets of 10 repetitions at 80% single repetition maximum unilateral KE exercise, three times weekly) and four weeks' supervised END (30 min combined continuous/interval cycling, three times weekly), separated by a three-week washout phase. Participants were genotyped for the ACTN3 rs1815739, NOS3 rs2070744 and VEGFA rs2010963 SNPs.
RESULTS: The intra-individual adaptations regarding percentage changes in MVIC force and V̇O following RT and END, respectively, were unrelated (r = 0.003; P = 0.79). However, a VEGFA genotype × training modality interaction (P = 0.007) demonstrated that VEGFA GG homozygotes increased their MVIC force after RT (+ 20.9 ± 13.2%) more than they increased their V̇O after END (+ 8.4 ± 9.1%, P = 0.005), and more than VEGFA C-allele carriers increased their MVIC force after RT (+ 12.2 ± 8.1%, P = 0.04). There were no genotype × training modality interactions for the ACTN3 or NOS3 SNPs.
CONCLUSION: High/low responders to RT were not consequently high/low responders to END or vice versa. However, preferential adaptation of VEGFA rs2010963 GG homozygotes to RT over END, and their greater adaptation to RT compared to VEGFA C-allele carriers, indicate a novel genetic predisposition for superior RT adaptation.
J Dent Res. 2007 Oct;86(10):937-50
[PMID:
17890669]
J Sci Med Sport. 2019 Jul;22(7):753-757
[PMID:
30755371]
Exp Physiol. 2011 Feb;96(2):145-55
[PMID:
20889606]
Hum Mol Genet. 2000 Nov 1;9(18):2629-37
[PMID:
11063722]
Am J Cardiol. 2000 Sep 15;86(6):628-34
[PMID:
10980213]
Acta Physiol (Oxf). 2010 May;199(1):83-9
[PMID:
20102343]
Med Sci Sports Exerc. 1998 May;30(5):724-31
[PMID:
9588615]
Scand J Med Sci Sports. 2012 Aug;22(4):523-33
[PMID:
21410539]
J Appl Physiol (1985). 2005 Jul;99(1):154-63
[PMID:
15718405]
Exp Physiol. 2009 Oct;94(10):1070-8
[PMID:
19638363]
Am J Phys Med. 1979 Jun;58(3):115-30
[PMID:
453338]
Eur J Appl Physiol. 2010 Dec;110(6):1117-25
[PMID:
20703498]
J Sports Sci. 2017 Apr;35(7):655-662
[PMID:
27211292]
Physiol Genomics. 2007 Dec 19;32(1):58-63
[PMID:
17848603]
Eur J Appl Physiol Occup Physiol. 1989;59(4):310-9
[PMID:
2583179]
J Appl Physiol (1985). 2015 Oct 15;119(8):858-64
[PMID:
26294751]
Eur J Appl Physiol. 2012 Aug;112(8):3061-8
[PMID:
22194005]
Breast Cancer Res Treat. 2008 Sep;111(1):157-63
[PMID:
17891484]
J Appl Physiol (1985). 2012 Apr;112(8):1329-34
[PMID:
22323655]
Eur J Appl Physiol. 2009 Nov;107(5):565-9
[PMID:
19701646]
PLoS One. 2020 Jun 22;15(6):e0234458
[PMID:
32569264]
Prog Mol Biol Transl Sci. 2015;135:129-51
[PMID:
26477913]
J Biol Chem. 1993 Aug 15;268(23):17478-88
[PMID:
7688726]
Eur J Appl Physiol. 2002 Nov;88(1-2):50-60
[PMID:
12436270]
J Muscle Res Cell Motil. 2006;27(8):577-84
[PMID:
17051348]
J Appl Physiol (1985). 1999 Sep;87(3):1003-8
[PMID:
10484570]
J Sports Sci Med. 2011 Jun 01;10(2):393-9
[PMID:
24149888]
Med Sci Sports Exerc. 2005 Jun;37(6):964-72
[PMID:
15947721]
Scand J Med Sci Sports. 2022 Feb;32(2):338-350
[PMID:
34633711]
Int J Environ Res Public Health. 2020 Feb 14;17(4):
[PMID:
32075076]
Sci Rep. 2019 Sep 3;9(1):12688
[PMID:
31481717]
Scand J Med Sci Sports. 2016 Jun;26(6):620-9
[PMID:
25946038]
J Clin Invest. 2013 Oct;123(10):4255-63
[PMID:
24091322]
Int J Sports Physiol Perform. 2015 Jul;10(5):636-41
[PMID:
25569611]
J Physiol. 2019 Apr;597(7):1873-1887
[PMID:
30727028]
Sports Med. 1989 Nov;8(5):302-20
[PMID:
2692122]
J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):206-12
[PMID:
17339648]
J Physiol. 2020 Sep;598(18):3845-3858
[PMID:
32567679]
Circ Res. 2003 Jun 13;92(11):1254-61
[PMID:
12750310]
J Appl Physiol (1985). 2007 Jan;102(1):368-73
[PMID:
17053104]
Behav Res Methods. 2005 Aug;37(3):379-84
[PMID:
16405133]
J Strength Cond Res. 2015 Feb;29(2):386-95
[PMID:
25259470]
Front Physiol. 2021 Mar 10;12:566023
[PMID:
33790801]
Genes (Basel). 2019 May 29;10(6):
[PMID:
31146466]
Eur J Sport Sci. 2016 Sep;16(6):694-701
[PMID:
26324221]
Am J Hum Genet. 2003 Sep;73(3):627-31
[PMID:
12879365]
Scand J Med Sci Sports. 2021 Aug;31(8):1683-1692
[PMID:
33899971]
Scand J Med Sci Sports. 2014 Aug;24(4):642-8
[PMID:
23384112]
Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1848-55
[PMID:
16339827]
Circ Res. 1998 Oct 19;83(8):832-40
[PMID:
9776730]
Scand J Med Sci Sports. 2015 Oct;25(5):640-9
[PMID:
25077768]
J Physiol. 2011 Mar 1;589(Pt 5):1195-208
[PMID:
21224224]
Age (Dordr). 2013 Oct;35(5):1949-59
[PMID:
22855367]
Biol Sport. 2018 Dec;35(4):313-319
[PMID:
30765915]
