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12 02, 2022;8 (48): eadc8829.

DNA repair during nonreductional meiosis in the asexual rotifer .

Matthieu Terwagne, Emilien Nicolas, Boris Hespeels, Ludovic Herter, Julie Virgo, Catherine Demazy, Anne-Catherine Heuskin, Bernard Hallet, Karine Van Doninck
Author Information
  1. Matthieu Terwagne: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium. ORCID
  2. Emilien Nicolas: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium. ORCID
  3. Boris Hespeels: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium.
  4. Ludovic Herter: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium.
  5. Julie Virgo: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium.
  6. Catherine Demazy: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium. ORCID
  7. Anne-Catherine Heuskin: Laboratory of Analysis by Nuclear Reaction (LARN), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium. ORCID
  8. Bernard Hallet: Institute of Biomolecular Science and Technology (LIBST), Université Catholique de Louvain (UCLouvain), Louvain-la-Neuve 1348, Belgium. ORCID
  9. Karine Van Doninck: Research Unit in Environmental and Evolutionary Biology (URBE), Laboratory of Evolutionary Genetics and Ecology (LEGE), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium. ORCID
PMID: 36449626 DOI: 10.1126/sciadv.adc8829

Abstract

Rotifers of the class Bdelloidea are microscopic animals notorious for their long-term persistence in the apparent absence of sexual reproduction and meiotic recombination. This evolutionary paradox is often counterbalanced by invoking their ability to repair environmentally induced genome breakage. By studying the dynamics of DNA damage response in the bdelloid species , we found that it occurs rapidly in the soma, producing a partially reassembled genome. By contrast, germline DNA repair is delayed to a specific time window of oogenesis during which homologous chromosomes adopt a meiotic-like juxtaposed configuration, resulting in accurate reconstitution of the genome in the offspring. Our finding that a noncanonical meiosis is the mechanism of germline DNA repair in bdelloid rotifers gives previously unidentified insights on their enigmatic long-term evolution.

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MeSH Term

Animals
Meiosis
DNA Repair
Reproduction
Journal Article

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