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02, 2023;21 (2): e3002013.

A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex.

Luciana López-Jury, Francisco García-Rosales, Eugenia González-Palomares, Johannes Wetekam, Michael Pasek, Julio C Hechavarria
Author Information
  1. Luciana López-Jury: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany. ORCID
  2. Francisco García-Rosales: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany. ORCID
  3. Eugenia González-Palomares: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany.
  4. Johannes Wetekam: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany. ORCID
  5. Michael Pasek: Institut für Theoretische Physik, Goethe University, Frankfurt am Main, Germany. ORCID
  6. Julio C Hechavarria: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany. ORCID
PMID: 36802356 DOI: 10.1371/journal.pbio.3002013

Abstract

Substantial progress in the field of neuroscience has been made from anaesthetized preparations. Ketamine is one of the most used drugs in electrophysiology studies, but how ketamine affects neuronal responses is poorly understood. Here, we used in vivo electrophysiology and computational modelling to study how the auditory cortex of bats responds to vocalisations under anaesthesia and in wakefulness. In wakefulness, acoustic context increases neuronal discrimination of natural sounds. Neuron models predicted that ketamine affects the contextual discrimination of sounds regardless of the type of context heard by the animals (echolocation or communication sounds). However, empirical evidence showed that the predicted effect of ketamine occurs only if the acoustic context consists of low-pitched sounds (e.g., communication calls in bats). Using the empirical data, we updated the naïve models to show that differential effects of ketamine on cortical responses can be mediated by unbalanced changes in the firing rate of feedforward inputs to cortex, and changes in the depression of thalamo-cortical synaptic receptors. Combined, our findings obtained in vivo and in silico reveal the effects and mechanisms by which ketamine affects cortical responses to vocalisations.

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MeSH Term

Animals
Auditory Cortex
Acoustic Stimulation
Ketamine
Chiroptera
Anesthesia
Neurons
Auditory Perception

Chemicals

Ketamine
Journal Article Research Support, Non-U.S. Gov't

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