OpenLB
Open Library of Bioscience
Advanced Search
Cancers
Feb 20, 2023;15 (4):

Implications of Transglutaminase-Mediated Protein Serotonylation in the Epigenetic Landscape, Small Cell Lung Cancer, and Beyond.

Jason Lin, Shang-Chuen Wu
Author Information
  1. Jason Lin: Laboratory of Clinical Genomics, Chiba Cancer Center Research Institute, Chiba Cancer Center, Chiba 260-8717, Japan. ORCID
  2. Shang-Chuen Wu: Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ORCID
PMID: 36831672 DOI: 10.3390/cancers15041332

Abstract

In the case of small-cell lung carcinoma, the highly metastatic nature of the disease and the propensity for several chromatin modifiers to harbor mutations suggest that epigenetic manipulation may also be a promising route for oncotherapy, but histone deacetylase inhibitors on their own do not appear to be particularly effective, suggesting that there may be other regulatory parameters that dictate the effectiveness of vorinostat's reversal of histone deacetylation. Recent discoveries that serotonylation of histone H3 alters the permissibility of gene expression have led to renewed attention to this rare modification, as facilitated by transglutaminase 2, and at the same time introduce new questions about whether this modification belongs to a part of the concerted cohort of regulator events for modulating the epigenetic landscape. This review explores the mechanistic details behind protein serotonylation and its possible connections to the epigenome via histone modifications and glycan interactions and attempts to elucidate the role of transglutaminase 2, such that optimizations to existing histone deacetylase inhibitor designs or combination therapies may be devised for lung and other types of cancer.

Keywords

epigenomics histone deacetylase inhibitor serotonylation

References

PLoS Biol. 2007 Dec;5(12):e327 [PMID: 18092889]
Amino Acids. 2013 Jan;44(1):151-9 [PMID: 21935707]
PLoS Biol. 2009 Oct;7(10):e1000229 [PMID: 19859528]
Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15;306(4):L309-15 [PMID: 24375797]
Biochemistry. 1974 Jul 30;13(16):3257-62 [PMID: 4841063]
Cancer Sci. 2020 Feb;111(2):561-570 [PMID: 31782583]
Cancers (Basel). 2021 Feb 10;13(4): [PMID: 33578789]
J Oncol. 2019 Dec 11;2019:3267207 [PMID: 31885572]
FEBS Open Bio. 2020 Nov;10(11):2305-2315 [PMID: 32902187]
Amino Acids. 2013 Oct;45(4):857-64 [PMID: 23797785]
Nature. 1989 Jul 6;340(6228):35-41 [PMID: 2739723]
Chembiochem. 2013 May 10;14(7):813-7 [PMID: 23592595]
J Exp Clin Cancer Res. 2021 Jul 5;40(1):224 [PMID: 34225780]
Trends Biochem Sci. 2016 Apr;41(4):311-323 [PMID: 26874923]
J Mol Biol. 2007 Apr 6;367(4):1118-29 [PMID: 17303166]
Chembiochem. 2015 Jul 27;16(11):1555-9 [PMID: 26096673]
Nucleic Acids Res. 2010 Oct;38(19):6350-62 [PMID: 20525793]
Front Microbiol. 2021 Oct 08;12:731026 [PMID: 34690972]
J Biomol Screen. 2011 Dec;16(10):1153-69 [PMID: 22086720]
ACS Chem Neurosci. 2015 Jul 15;6(7):961-9 [PMID: 25615632]
Signal Transduct Target Ther. 2019 May 10;4:15 [PMID: 31098305]
J Immunol. 2008 Mar 1;180(5):3091-102 [PMID: 18292532]
Biochem J. 2002 Dec 1;368(Pt 2):377-96 [PMID: 12366374]
Glycobiology. 2018 Apr 1;28(4):172-181 [PMID: 29315388]
Mol Cell. 2012 Nov 30;48(4):491-507 [PMID: 23200123]
Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13331-6 [PMID: 22853951]
Molecules. 2015 Jan 15;20(1):1452-74 [PMID: 25599150]
Cold Spring Harb Perspect Biol. 2014 Apr 01;6(4):a018713 [PMID: 24691964]
Am J Respir Cell Mol Biol. 2011 Apr;44(4):548-55 [PMID: 20558776]
Diabetol Metab Syndr. 2017 Jan 3;9:1 [PMID: 28053672]
Amino Acids. 2012 Feb;42(2-3):1037-43 [PMID: 21805137]
Curr Opin Struct Biol. 2018 Dec;53:169-177 [PMID: 30391813]
Nat Rev Immunol. 2009 May;9(5):338-52 [PMID: 19365409]
Nat Chem Biol. 2021 Jan;17(1):47-56 [PMID: 32807969]
Cancer Res. 2019 Sep 15;79(18):4754-4766 [PMID: 31358528]
Mol Cell. 2012 May 11;46(3):369-76 [PMID: 22483618]
Cancers (Basel). 2019 Jul 08;11(7): [PMID: 31288436]
Int J Cancer. 2010 Feb 1;126(3):743-55 [PMID: 19621389]
Nature. 2014 Mar 6;507(7490):104-8 [PMID: 24463520]
Exp Cell Res. 1998 Feb 25;239(1):119-38 [PMID: 9511731]
Nat Commun. 2018 Mar 28;9(1):1243 [PMID: 29593341]
FEBS Lett. 2003 Jan 16;534(1-3):180-4 [PMID: 12527383]
FEBS Lett. 2004 Oct 8;576(1-2):57-62 [PMID: 15474010]
Cancer Treat Res Commun. 2022 Jan 7;30:100509 [PMID: 35026535]
Cell. 2003 Dec 26;115(7):851-62 [PMID: 14697203]
Cancer Lett. 2021 Jun 28;508:76-91 [PMID: 33775711]
J Invest Dermatol. 1979 Sep;73(3):256-8 [PMID: 38285]
PLoS One. 2012;7(5):e36980 [PMID: 22693562]
Nature. 2019 Mar;567(7749):535-539 [PMID: 30867594]
Cell Res. 2011 Mar;21(3):381-95 [PMID: 21321607]
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62 [PMID: 18711143]
Biomolecules. 2020 Apr 03;10(4): [PMID: 32260120]
Curr Opin Immunol. 1994 Oct;6(5):728-32 [PMID: 7826528]
Amino Acids. 2009 Apr;36(4):625-31 [PMID: 18584284]
Am Fam Physician. 2007 Dec 15;76(12):1795-802 [PMID: 18217518]
FEBS Lett. 2004 Dec 3;578(1-2):80-4 [PMID: 15581620]
Nature. 2021 Aug;596(7873):583-589 [PMID: 34265844]
Biochimie. 2019 Jun;161:56-64 [PMID: 29909048]
Exp Mol Med. 2022 Dec;54(12):2118-2127 [PMID: 36509828]
J Biol Chem. 1998 Feb 27;273(9):4831-4 [PMID: 9478922]
Front Biosci. 2007 Jan 01;12:891-904 [PMID: 17127346]
Fac Rev. 2021 Jun 01;10:52 [PMID: 34195691]
Oncotarget. 2017 Jul 11;8(28):45577-45584 [PMID: 28715877]
Protein Cell. 2022 Aug;13(8):580-601 [PMID: 35147915]
Sci Rep. 2012;2:544 [PMID: 22848790]
Proc Biol Sci. 2022 Nov 9;289(1986):20221565 [PMID: 36321487]
Cancer Cell. 2008 Nov 4;14(5):355-68 [PMID: 18977325]
Oncol Res. 2018 Sep 14;26(8):1175-1182 [PMID: 29301592]
Biochem J. 2003 Aug 1;373(Pt 3):793-803 [PMID: 12737632]
Nat Rev Mol Cell Biol. 2007 Dec;8(12):983-94 [PMID: 18037899]
FEBS J. 2011 Dec;278(24):4740-55 [PMID: 21923757]
Biol Open. 2022 Jan 15;11(1): [PMID: 35076063]
Thorac Cancer. 2020 Jan;11(1):120-129 [PMID: 31760702]
PLoS One. 2009 May 25;4(5):e5682 [PMID: 19479059]
iScience. 2022 May 30;25(7):104482 [PMID: 35754739]
J Thorac Oncol. 2017 Apr;12(4):704-713 [PMID: 28007623]
Curr Opin Cell Biol. 2007 Jun;19(3):266-72 [PMID: 17466502]
Mol Oncol. 2012 Dec;6(6):579-89 [PMID: 22963873]
Nature. 2015 Aug 6;524(7563):47-53 [PMID: 26168399]
Proc Natl Acad Sci U S A. 2021 Feb 9;118(6): [PMID: 33526675]
Cell. 2013 Mar 28;153(1):38-55 [PMID: 23540689]
J Transl Med. 2014 Sep 27;12:273 [PMID: 25260879]
PLoS Genet. 2012 Sep;8(9):e1002934 [PMID: 23028349]
Exp Cell Res. 2012 Jul 1;318(11):1229-44 [PMID: 22336671]
Annu Rev Pharmacol Toxicol. 2003;43:261-84 [PMID: 12359863]
BMC Cancer. 2019 Jan 16;19(1):79 [PMID: 30651077]
PLoS One. 2010 Nov 19;5(11):e14056 [PMID: 21124911]
Nat Rev Mol Cell Biol. 2003 Feb;4(2):140-56 [PMID: 12563291]
Cell. 2011 Sep 16;146(6):1016-28 [PMID: 21925322]
Mol Cell Biol. 1999 Jun;19(6):4535-45 [PMID: 10330192]
Nat Commun. 2012 Feb 14;3:676 [PMID: 22334079]
Expert Rev Mol Med. 2008 Jun 13;10:e17 [PMID: 18549522]
Nat Struct Mol Biol. 2012 Dec;19(12):1218-27 [PMID: 23211769]
FEBS Lett. 2012 Nov 2;586(21):3819-24 [PMID: 23022564]
Mol Cells. 2003 Aug 31;16(1):84-91 [PMID: 14503850]
Cold Spring Harb Perspect Biol. 2016 Apr 01;8(4):a019521 [PMID: 27037415]
Nat Methods. 2023 Feb;20(2):205-213 [PMID: 36424442]
Mol Cell Proteomics. 2007 May;6(5):812-9 [PMID: 17267393]
J Biol Chem. 2011 Oct 28;286(43):37094-107 [PMID: 21896482]
BMC Cancer. 2009 Jan 30;9:40 [PMID: 19183436]
Oncotarget. 2017 Nov 14;8(64):107947-107963 [PMID: 29296215]
Gastroenterology. 2001 May;120(6):1522-5 [PMID: 11313323]
Science. 2004 Oct 8;306(5694):279-83 [PMID: 15345777]
J Biol Chem. 2010 Aug 13;285(33):25402-9 [PMID: 20547769]
Cancer Sci. 2021 May;112(5):2060-2062 [PMID: 33690908]
Nature. 2019 Oct;574(7779):575-580 [PMID: 31645732]
J Biol Chem. 2007 Feb 2;282(5):2918-28 [PMID: 17142836]
Mol Cancer. 2011 Sep 24;10:119 [PMID: 21943122]
FEBS J. 2020 Mar;287(6):1155-1175 [PMID: 31599112]
Clin Cancer Res. 2010 Apr 1;16(7):2122-30 [PMID: 20332322]
Oncol Rep. 2019 Jan;41(1):525-533 [PMID: 30365122]
Clin Cancer Res. 2019 Nov 15;25(22):6623-6632 [PMID: 31409616]
PLoS One. 2017 Aug 28;12(8):e0183760 [PMID: 28846729]
Nat Rev Cancer. 2005 Jan;5(1):29-41 [PMID: 15630413]
J Proteome Res. 2014 Aug 1;13(8):3523-9 [PMID: 25055207]
Science. 2020 Apr 10;368(6487):197-201 [PMID: 32273471]
Sci Transl Med. 2021 Sep 15;13(611):eabc8188 [PMID: 34524861]
BMC Cancer. 2016 Nov 7;16(1):857 [PMID: 27821078]
Genes Dev. 1991 Jun;5(6):897-907 [PMID: 2044958]
Expert Rev Proteomics. 2005 Oct;2(5):719-29 [PMID: 16209651]
Nature. 2005 Jun 30;435(7046):1262-6 [PMID: 15988529]

Grants

  1. 21K15072/Japan Society for the Promotion of Science
Journal Article Review

Word Cloud

Similar Articles

Cited By