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Cell death & disease
03 04, 2023;14 (3): 178.

TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion.

Qing Zhang, Jianglin Zheng, Wenjie Wu, Haiyan Lian, Natasha Iranzad, Endi Wang, Lianhe Yang, Xuan Wang, Xiaobing Jiang
Author Information
  1. Qing Zhang: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  2. Jianglin Zheng: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  3. Wenjie Wu: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  4. Haiyan Lian: Department of Ophthalmology, Jili Hospital of Liuyang (Liuyang Eye Hospital), Changsha, 410300, China.
  5. Natasha Iranzad: Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA.
  6. Endi Wang: Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA. ORCID
  7. Lianhe Yang: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110013, Liaoning, China.
  8. Xuan Wang: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. highprefer@126.com. ORCID
  9. Xiaobing Jiang: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. jiangxiaobing@hust.edu.cn.
PMID: 36870986 DOI: 10.1038/s41419-023-05702-6

Abstract

Diffuse invasion is an important factor leading to treatment resistance and a poor prognosis in gliomas. Herein, we found that expression of the tripartite motif containing 56 (TRIM56), a RING-finger domain containing E3 ubiquitin ligase, was markedly higher in glioma than in normal brain tissue, and was significantly correlated with malignant phenotypes and a poor prognosis. In vitro and in vivo experimental studies revealed that TRIM56 promoted the migration and invasion of glioma cells. Mechanistically, TRIM56 was transcriptionally regulated by SP1 and promoted the K48-K63-linked poly-ubiquitination transition of IQGAP1 at Lys-1230 by interacting with it, which in turn promoted CDC42 activation. This mechanism was confirmed to mediate glioma migration and invasion. In conclusion, our study provides insights into the mechanisms through which TRIM56 promotes glioma motility, i.e., by regulating IQGAP1 ubiquitination to promote CDC42 activation, which might be clinically targeted for the treatment of glioma.

References

Pharmacol Ther. 2021 Nov;227:107881 [PMID: 33930453]
Cancer Res. 2015 Nov 1;75(21):4527-37 [PMID: 26359454]
CA Cancer J Clin. 2010 May-Jun;60(3):166-93 [PMID: 20445000]
Nat Rev Neurosci. 2014 Jul;15(7):455-65 [PMID: 24946761]
Cancer Manag Res. 2021 Mar 04;13:2201-2213 [PMID: 33707970]
Cell. 2013 Mar 28;153(1):139-52 [PMID: 23540695]
FEBS J. 2015 Jan;282(2):224-58 [PMID: 25393971]
Nat Commun. 2019 Apr 3;10(1):1523 [PMID: 30944313]
J Exp Clin Cancer Res. 2009 Sep 22;28:129 [PMID: 19772640]
Oncogenesis. 2019 Apr 18;8(5):30 [PMID: 31000690]
Nature. 2006 Dec 7;444(7120):756-60 [PMID: 17051156]
Pharmacol Ther. 2015 Aug;152:111-24 [PMID: 25960131]
Cancers (Basel). 2018 Nov 20;10(11): [PMID: 30463322]
Neuro Oncol. 2020 Oct 14;22(10):1439-1451 [PMID: 32328646]
EMBO J. 2012 Mar 7;31(5):1109-22 [PMID: 22234184]
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6242-4 [PMID: 10841526]
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102 [PMID: 28407145]
Oncogene. 2014 Jul 31;33(31):4021-35 [PMID: 24037532]
Cancer Commun (Lond). 2022 Sep;42(9):868-886 [PMID: 35848447]
Science. 1998 Aug 7;281(5378):832-5 [PMID: 9694656]
Comput Math Methods Med. 2021 Mar 25;2021:5594973 [PMID: 33833824]
Cell Death Differ. 2019 Oct;26(10):1970-1986 [PMID: 30670829]
Cancer Cell. 2009 Jun 2;15(6):501-13 [PMID: 19477429]
Expert Rev Clin Immunol. 2020 Oct;16(10):973-984 [PMID: 32903131]
Trends Mol Med. 2018 Sep;24(9):763-780 [PMID: 30072121]
Cancers (Basel). 2011 Jan 27;3(1):461-77 [PMID: 24212625]
J Virol. 2011 Apr;85(8):3733-45 [PMID: 21289118]
Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):722-730 [PMID: 33577026]
Nat Cell Biol. 2019 Jul;21(7):845-855 [PMID: 31209295]
Oncogene. 2008 Nov 6;27(52):6679-89 [PMID: 18724390]
Annu Rev Cell Dev Biol. 2017 Oct 6;33:77-101 [PMID: 28783960]
EMBO Rep. 2003 Jun;4(6):571-4 [PMID: 12776176]
J Exp Clin Cancer Res. 2022 Dec 6;41(1):336 [PMID: 36471347]
Br J Cancer. 2017 Sep 26;117(7):1036-1047 [PMID: 28787434]
J Cell Biol. 2005 May 9;169(3):515-26 [PMID: 15866889]
Mol Neurobiol. 2022 Sep;59(9):5312-5325 [PMID: 35696011]
J Cell Biol. 2008 Jun 16;181(6):985-98 [PMID: 18541705]
Adv Sci (Weinh). 2021 Nov;8(22):e2100914 [PMID: 34609794]
Clin Chem. 2013 Jun;59(6):892-902 [PMID: 23570709]
Onco Targets Ther. 2020 Dec 31;13:13401-13411 [PMID: 33408486]
Neuro Oncol. 2017 Jan;19(1):139-141 [PMID: 28031383]
Trends Biochem Sci. 2017 Apr;42(4):297-311 [PMID: 28118948]
J Virol. 2016 Apr 14;90(9):4369-4382 [PMID: 26889027]
Physiol Rev. 2022 Jan 1;102(1):455-510 [PMID: 34541899]
Cancer Lett. 2019 Feb 1;442:445-452 [PMID: 30472185]
Cell Signal. 2012 Apr;24(4):826-34 [PMID: 22182509]
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [PMID: 16199517]
Nucleic Acids Res. 2001 Dec 15;29(24):4920-9 [PMID: 11812820]
Nat Commun. 2018 Feb 9;9(1):613 [PMID: 29426904]
Curr Biol. 2006 Nov 21;16(22):2259-64 [PMID: 17113391]
J Exp Clin Cancer Res. 2022 Jul 22;41(1):230 [PMID: 35869555]
Viruses. 2022 Jan 05;14(1): [PMID: 35062293]
Sci Adv. 2021 Jul 9;7(28): [PMID: 34244134]
Int J Biol Sci. 2021 Apr 17;17(7):1716-1730 [PMID: 33994856]
Cancer Cell. 2016 Jun 13;29(6):846-858 [PMID: 27238081]
Yonsei Med J. 2018 Jan;59(1):43-50 [PMID: 29214775]
Redox Biol. 2017 Oct;13:655-664 [PMID: 28822335]
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1261-6 [PMID: 23284167]
J Biol Chem. 2018 Jul 13;293(28):11143-11153 [PMID: 29853638]
Cancer Lett. 2021 Apr 1;502:1-8 [PMID: 33279622]
Redox Biol. 2022 Jul;53:102344 [PMID: 35636015]
Nat Rev Cancer. 2011 Oct 07;11(11):792-804 [PMID: 21979307]
J Biol Chem. 2020 Apr 10;295(15):4822-4835 [PMID: 32094223]
Mol Cell Probes. 2020 Oct;53:101623 [PMID: 32603762]
N Engl J Med. 2005 Mar 10;352(10):987-96 [PMID: 15758009]
Neuro Oncol. 2016 Jan;18 Suppl 1:i1-i50 [PMID: 26705298]
Cancer Res. 2019 Oct 1;79(19):4978-4993 [PMID: 31431460]

MeSH Term

Humans
Cell Movement
Brain
Glioma
Phenotype
Tripartite Motif Proteins
Ubiquitin-Protein Ligases

Chemicals

IQ motif containing GTPase activating protein 1
TRIM56 protein, human
Tripartite Motif Proteins
Ubiquitin-Protein Ligases
Journal Article Research Support, Non-U.S. Gov't

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