OpenLB
Open Library of Bioscience
Advanced Search
Biomarkers in medicine
01, 2023;17 (2): 73-85.

PAPP-A as a screening tool for assessment of gestational age before medication abortion in an intended-use population.

Laura J Frye, Irina A Buhimschi, Elizabeth G Raymond, Guomao Zhao, Beverly Winikoff
Author Information
  1. Laura J Frye: Gynuity Health Projects, 220 East 42nd Street New York, NY 10017, USA. ORCID
  2. Irina A Buhimschi: Department of Obstetrics & Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
  3. Elizabeth G Raymond: Gynuity Health Projects, 220 East 42nd Street New York, NY 10017, USA.
  4. Guomao Zhao: Department of Obstetrics & Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
  5. Beverly Winikoff: Gynuity Health Projects, 220 East 42nd Street New York, NY 10017, USA.
PMID: 37038980 DOI: 10.2217/bmm-2022-0653

Abstract

Prior studies indicate that PAPP-A could serve as a marker of gestational age (GA) with the potential to determine eligibility for medication abortion. The authors validated the relationship between PAPP-A and GA in an actual-use population. The authors collected blood samples, medical histories and ultrasound-determined GA from patients presenting for abortion services. They measured PAPP-A using two immunoassays and assessed diagnostic accuracy for predicting GA ≥71 days. The Ansh Labs and R&D Systems immunoassays produced an area under the ROC curve of 0.982 (95% CI: 0.958-0.994) and 0.986 (95% CI: 0.963-0.996), respectively, for predicting GA ≥71 days. This validation study in an intended-use population confirmed that PAPP-A has a strong ability to distinguish pregnancies above and below 71 days' gestation. : NCT04232189 (ClinicalTrials.gov).

Keywords

PAPP-A biomarker gestational age medication abortion

Associated Data

ClinicalTrials.gov | NCT04232189

References

Contraception. 2019 Feb;99(2):77-86 [PMID: 30444970]
BMJ. 2016 Nov 7;355:i5662 [PMID: 27821614]
Placenta. 1980 Jan-Mar;1(1):77-89 [PMID: 6160571]
Biochem Med (Zagreb). 2012;22(2):145-9 [PMID: 22838180]
Radiology. 1983 Sep;148(3):839-43 [PMID: 6878708]
J Obstet Gynaecol Can. 2020 Dec;42(12):1532-1542.e2 [PMID: 32912726]
Prenat Diagn. 2003 Feb;23(2):157-62 [PMID: 12575025]
Ann Clin Biochem. 1983 Jan;20 Pt 1:26-30 [PMID: 6188409]
Contraception. 2020 May;101(5):309-314 [PMID: 32014519]
J Appl Lab Med. 2022 Jun 30;7(4):1000-1002 [PMID: 35661888]
J Med Screen. 2010;17(3):109-13 [PMID: 20956719]
Br J Obstet Gynaecol. 1994 Nov;101(11):970-4 [PMID: 7528054]
N Engl J Med. 1975 Jul 31;293(5):257 [PMID: 1143310]
BMJ. 2004 Jul 17;329(7458):168-9 [PMID: 15258077]
J Appl Lab Med. 2022 Jun 30;7(4):1002-1004 [PMID: 35661213]
Biometrics. 1988 Sep;44(3):837-45 [PMID: 3203132]
Biometrics. 1989 Mar;45(1):255-68 [PMID: 2720055]
Contraception. 2013 Jan;87(1):26-37 [PMID: 22898359]
J Biomed Inform. 2009 Apr;42(2):377-81 [PMID: 18929686]
Ultrasound Obstet Gynecol. 2015 Jul;46(1):42-50 [PMID: 25847022]
J Appl Lab Med. 2021 Nov 1;6(6):1517-1532 [PMID: 34329446]

Grants

  1. UL1 TR000445/NCATS NIH HHS

MeSH Term

Pregnancy
Female
Humans
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A
Gestational Age
Abortion, Induced
ROC Curve
Biomarkers

Chemicals

Pregnancy-Associated Plasma Protein-A
Biomarkers
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Word Cloud

Similar Articles

Cited By