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Toxicology reports
2023;10 436-440.

Xanthomicrol: Effective therapy for cancer treatment.

Neda Poormolaie, Mohammad Mohammadi, Amirabbas Mir, Mehrdad Asadi, Alireza Nouhi Kararoudi, Vahid Vahedian, Mohsen Rashidi, Nazila Fathi Maroufi
Author Information
  1. Neda Poormolaie: Department of Biochemistry, Faculty of Biology Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
  2. Mohammad Mohammadi: Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  3. Amirabbas Mir: Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran.
  4. Mehrdad Asadi: Department of Medical Laboratory Sciences and Microbiology, Faculty of Medical Sciences, Tabriz Medical sciences, Islamic Azad University,Tabriz, Iran.
  5. Alireza Nouhi Kararoudi: Department of Molecular Cell Biology, Rasht Branch of Islamic Azad University, Rasht, Iran.
  6. Vahid Vahedian: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  7. Mohsen Rashidi: The Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  8. Nazila Fathi Maroufi: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
PMID: 37102154 DOI: 10.1016/j.toxrep.2023.02.008

Abstract

Cancer treatment is one of the main challenges of global health. For decades, researchers have been trying to find anti-cancer compounds with minimal side effects. In recent years, flavonoids, as a group of polyphenolic compounds, have attracted the attention of researchers due to their beneficial effects on health. Xanthomicrol is one of the flavonoids that has the ability to inhibit growth, proliferation, survival and cell invasion and ultimately tumor progression. Xanthomicrol, as active anti-cancer compounds, can be effective in the prevention and treatment of cancer. Therefore, the use of flavonoids can be suggested as a treatment along with other medicinal agents. It is obvious that additional investigations in cellular levels and animal models are still needed. In this review article, the effects of xanthomicrol on various cancers have been reviewed.

Keywords

Apoptosis Cancer Treatment Xanthomicrol

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