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Pharmaceutics
Jul 14, 2023;15 (7):

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles.

Shahla Ranjbar, Abbasali Emamjomeh, Fatemeh Sharifi, Atefeh Zarepour, Kian Aghaabbasi, Ali Dehshahri, Azadeh Mohammadi Sepahvand, Ali Zarrabi, Hamid Beyzaei, Mohammad Mehdi Zahedi, Reza Mohammadinejad
Author Information
  1. Shahla Ranjbar: Department of Plant Breeding and Biotechnology, Faculty of Agriculture, University of Zabol, Zabol 9861335856, Iran.
  2. Abbasali Emamjomeh: Department of Plant Breeding and Biotechnology, Faculty of Agriculture, University of Zabol, Zabol 9861335856, Iran. ORCID
  3. Fatemeh Sharifi: Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7616913555, Iran. ORCID
  4. Atefeh Zarepour: Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, 34396 Istanbul, Turkey. ORCID
  5. Kian Aghaabbasi: Department of Biotechnology, University of Guilan, University Campus 2, Khalij Fars Highway 5th km of Ghazvin Road, Rasht 4199613776, Iran.
  6. Ali Dehshahri: Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz 7146864685, Iran. ORCID
  7. Azadeh Mohammadi Sepahvand: Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz 7146864685, Iran.
  8. Ali Zarrabi: Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, 34396 Istanbul, Turkey. ORCID
  9. Hamid Beyzaei: Department of Chemistry, Faculty of Science, University of Zabol, Zabol 9861335856, Iran.
  10. Mohammad Mehdi Zahedi: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
  11. Reza Mohammadinejad: Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
PMID: 37514130 DOI: 10.3390/pharmaceutics15071944

Abstract

Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Based on the studies, high hydrophobic properties of the aforementioned compounds limit their bioavailability inside the human body and restrict their wide application. Nanoscale formulations such as solid lipid nanoparticles, liposomes, and other types of lipid-based delivery systems have been introduced to overcome the above-mentioned challenges. This approach allows the aforementioned hydrophobic therapeutic compounds to be encapsulated between hydrophobic structures, resulting in improving their bioavailability. The above-mentioned enhanced delivery system improves delivery to the targeted sites and reduces the daily required dosage. Lowering the required daily dose improves the performance of the drug by diminishing its side effects on non-targeted tissues. The present study aims to highlight the recent improvements in implementing lipid-based nanocarriers to deliver flavonolignans and flavonoids.

Keywords

bioavailability flavonoids flavonolignans lipid-based nanocarrier nanocarrier

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Grants

  1. IR-UOZ-GR-2874/Zabol University
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