OpenLB
Open Library of Bioscience
Advanced Search
Frontiers in cardiovascular medicine
2023;10 1147740.

Effect and possible mechanisms of saponins in Chinese herbal medicine exerts for the treatment of myocardial ischemia-reperfusion injury in experimental animal: a systematic review and meta-analysis.

Jiahao Sun, Jiarong Fan, Fan Yang, Xin Su, Xinye Li, Li Tian, Can Liu, Yanwei Xing
Author Information
  1. Jiahao Sun: Yanqing Hospital of Beijing Chinese Medicine Hospital, Beijing, China.
  2. Jiarong Fan: Clinical Department of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
  3. Fan Yang: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  4. Xin Su: Sun Yat-sen University Cancer Center, Guangzhou, China.
  5. Xinye Li: Clinical Department of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
  6. Li Tian: Clinical Department of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
  7. Can Liu: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  8. Yanwei Xing: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
PMID: 37564906 DOI: 10.3389/fcvm.2023.1147740

Abstract

Introduction: Preventing ischemia-reperfusion injury is the main direction of myocardial infarction treatment in the convalescent stage. Some studies have suggested that saponins in Traditional Chinese medicine (TCM) preparations can protect the myocardium by various mechanisms. Our meta-analysis aims to evaluate the efficacy of TCM saponins in treating myocardial ischemia-reperfusion injury (MIRI) and to summarize the potential molecular mechanisms further.
Methods: We conducted a literature search in six electronic databases [Web of Science, PubMed, Embase, Cochrane Library, Sinomed, China National Knowledge Infrastructure (CNKI)] until October 2022.
Results: Seventeen eligible studies included 386 animals (254 received saponins and 132 received vehicles). The random effect model is used to calculate the combined effect. The effect size is expressed as the weighted average difference (WMD) and 95% confidence interval (CI). Compared with placebo, saponins preconditioning reduced infarct size after MIRI significantly (WMD: -3.60,95% CI: -4.45 to -2.74,  < 0.01, : 84.7%,  < 0.001), and significantly increased EF (WMD: 3.119, 95% CI: 2.165 to 4.082,  < 0.01, : 82.9%,  < 0.0 L) and FS (WMD: 3.157, 95% CI: 2.218 to 4.097,  < 0.001, : 81.3%,  < 0.001).
Discussion: The results show that the pre-administration of saponins from TCM has a significant protective effect on MIRI in preclinical studies, which provides an application prospect for developing anti-MIRI drugs with high efficiency and low toxicity.

Keywords

cardiac function experimental animal model infarct size meta-analysis myocardial ischemia-reperfusion injury saponins traditional Chinese medicine

References

Chin J Integr Med. 2021 Aug;27(8):613-620 [PMID: 32418176]
Oxid Med Cell Longev. 2020 Sep 27;2020:5430407 [PMID: 33062142]
Acta Pharmacol Sin. 2019 May;40(5):599-607 [PMID: 30030530]
Biochem Biophys Res Commun. 2018 Sep 18;503(4):3219-3224 [PMID: 30146261]
Biomed Pharmacother. 2020 May;125:109963 [PMID: 32036220]
PLoS One. 2017 Feb 9;12(2):e0170984 [PMID: 28182689]
J Ethnopharmacol. 2012 Jan 31;139(2):504-12 [PMID: 22154967]
RSC Adv. 2018 Jul 2;8(42):23947-23962 [PMID: 35540288]
Zhonghua Yi Xue Za Zhi. 1994 Oct;74(10):626-8, 648 [PMID: 7842343]
Zhongguo Zhong Yao Za Zhi. 2004 Jan;29(1):71-4 [PMID: 15709388]
Front Pharmacol. 2021 Jan 14;11:570867 [PMID: 33597866]
Phytomedicine. 2022 Jun;100:154045 [PMID: 35338991]
Cell Physiol Biochem. 2014;34(4):1413-26 [PMID: 25301366]
Phytother Res. 2022 Jul;36(7):2982-2998 [PMID: 35624528]
Cell Prolif. 2019 Mar;52(2):e12563 [PMID: 30525268]
J Adv Res. 2020 Oct 31;34:173-186 [PMID: 35024189]
Pharmazie. 2015 Nov;70(11):740-4 [PMID: 26790191]
Phytomedicine. 2022 Jul;101:154123 [PMID: 35533608]
Pharmacology. 2008;81(4):325-32 [PMID: 18349554]
Biomed Pharmacother. 2022 Jan;145:112432 [PMID: 34798472]
Gen Physiol Biophys. 2015 Jul;34(3):323-9 [PMID: 26001291]
Biomed Pharmacother. 2020 Oct;130:110538 [PMID: 32731133]
Mol Med Rep. 2021 Jan;23(1): [PMID: 33236154]
Cell Physiol Biochem. 2018;49(4):1646-1658 [PMID: 30227401]
Front Cardiovasc Med. 2021 Sep 16;8:694219 [PMID: 34604348]
J Cardiovasc Pharmacol. 2021 Aug 05;78(5):e681-e689 [PMID: 34354001]
Front Pharmacol. 2021 Jul 19;12:642925 [PMID: 34349641]
J Med Food. 2021 Nov;24(11):1222-1229 [PMID: 34714126]
Front Pharmacol. 2022 Sep 05;13:975784 [PMID: 36133804]
J Cell Mol Med. 2017 Sep;21(9):1870-1880 [PMID: 28225183]
Oxid Med Cell Longev. 2022 May 27;2022:9626703 [PMID: 35669855]
Acta Cir Bras. 2019 Sep 12;34(7):e201900708 [PMID: 31531541]
Int J Mol Med. 2021 Jan;47(1):23-36 [PMID: 33155658]
Biosci Rep. 2021 May 10;: [PMID: 33969379]
Front Cell Dev Biol. 2020 Dec 23;8:616139 [PMID: 33425924]
Oxid Med Cell Longev. 2021 Nov 9;2021:5577019 [PMID: 34795840]
Exp Ther Med. 2016 Jun;11(6):2341-2348 [PMID: 27284318]
Molecules. 2018 Mar 01;23(3): [PMID: 29494523]
Phytomedicine. 2022 Oct;105:154358 [PMID: 35952578]
PLoS One. 2014 Sep 19;9(9):e107832 [PMID: 25238237]
J Muscle Res Cell Motil. 2021 Mar;42(1):17-31 [PMID: 31630282]
Int J Mol Med. 2015 Dec;36(6):1538-46 [PMID: 26498380]
J Mol Histol. 2022 Aug;53(4):713-727 [PMID: 35819738]
Exp Ther Med. 2014 Dec;8(6):1751-1756 [PMID: 25371727]
J Cardiovasc Pharmacol. 2014 Apr;63(4):323-32 [PMID: 24710469]
J Cardiovasc Pharmacol. 2019 Feb;73(2):92-99 [PMID: 30531436]
Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):701-711 [PMID: 28024940]
Cell Physiol Biochem. 2018;50(1):28-40 [PMID: 30278458]
Afr J Tradit Complement Altern Med. 2011;8(2):104-27 [PMID: 22238491]
Front Pharmacol. 2021 Jan 15;11:607813 [PMID: 33628178]
Biomed Res Int. 2020 Oct 20;2020:3039184 [PMID: 33134375]
Am J Transl Res. 2019 Jul 15;11(7):4046-4062 [PMID: 31396317]
Int Immunopharmacol. 2019 Feb;67:311-318 [PMID: 30572256]
Cell Physiol Biochem. 2018;49(4):1277-1288 [PMID: 30205393]
Food Chem Toxicol. 2010 Jun;48(6):1516-20 [PMID: 20353807]
Mol Biosyst. 2017 Jul 25;13(8):1504-1511 [PMID: 28632266]
J Evid Based Med. 2015 Feb;8(1):2-10 [PMID: 25594108]
J Ginseng Res. 2015 Jul;39(3):206-12 [PMID: 26199551]
Sci Rep. 2016 Feb 18;6:21730 [PMID: 26888485]
Oxid Med Cell Longev. 2020 Aug 31;2020:2415269 [PMID: 32934760]
Journal Article Review

Word Cloud

Similar Articles

Cited By