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ACS biomaterials science & engineering
09 11, 2023;9 (9): 5222-5254.

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems.

Aleksandra Szwed-Georgiou, Przemysław Płociński, Barbara Kupikowska-Stobba, Mateusz M Urbaniak, Paulina Rusek-Wala, Konrad Szustakiewicz, Paweł Piszko, Agnieszka Krupa, Monika Biernat, Małgorzata Gazińska, Mirosław Kasprzak, Katarzyna Nawrotek, Nuno Pereira Mira, Karolina Rudnicka
Author Information
  1. Aleksandra Szwed-Georgiou: Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland.
  2. Przemysław Płociński: Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland.
  3. Barbara Kupikowska-Stobba: Biomaterials Research Group, Lukasiewicz Research Network - Institute of Ceramics and Building Materials, Krakow 31-983, Poland.
  4. Mateusz M Urbaniak: Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland. ORCID
  5. Paulina Rusek-Wala: Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland. ORCID
  6. Konrad Szustakiewicz: Department of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, Poland.
  7. Paweł Piszko: Department of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, Poland. ORCID
  8. Agnieszka Krupa: Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland.
  9. Monika Biernat: Biomaterials Research Group, Lukasiewicz Research Network - Institute of Ceramics and Building Materials, Krakow 31-983, Poland.
  10. Małgorzata Gazińska: Department of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, Poland. ORCID
  11. Mirosław Kasprzak: Biomaterials Research Group, Lukasiewicz Research Network - Institute of Ceramics and Building Materials, Krakow 31-983, Poland.
  12. Katarzyna Nawrotek: Faculty of Process and Environmental Engineering, Lodz University of Technology, Lodz 90-924, Poland. ORCID
  13. Nuno Pereira Mira: iBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, Portugal. ORCID
  14. Karolina Rudnicka: Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland.
PMID: 37585562 DOI: 10.1021/acsbiomaterials.3c00609

Abstract

Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials that allow the coordinated and well-controlled repair of bone fractures and bone loss are being designed to reduce the need for autologous or allogeneic bone grafts eventually. The current engineering technologies permit the construction of synthetic, complex, biomimetic biomaterials with properties nearly as good as those of natural bone with good biocompatibility. To ensure that all these requirements meet, bioactive molecules are coupled to structural scaffolding constituents to form a final product with the desired physical, chemical, and biological properties. Bioactive molecules that have been used to promote bone regeneration include protein growth factors, peptides, amino acids, hormones, lipids, and flavonoids. Various strategies have been adapted to investigate the coupling of bioactive molecules with scaffolding materials to sustain activity and allow controlled release. The current manuscript is a thorough survey of the strategies that have been exploited for the delivery of biomolecules for bone regeneration purposes, from choosing the bioactive molecule to selecting the optimal strategy to synthesize the scaffold and assessing the advantages and disadvantages of various delivery strategies.

Keywords

bioactive materials biomaterials biomolecule delivery systems biomolecules bone healing bone regeneration composites scaffolds

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MeSH Term

Tissue Engineering
Biocompatible Materials
Bone Regeneration
Bone and Bones
Peptides

Chemicals

Biocompatible Materials
Peptides
Journal Article Review Research Support, Non-U.S. Gov't

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