Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Irritable bowel syndrome (IBS) affects approximately one tenth of the general population and is characterized by abdominal pain associated with abnormalities in bowel habits. Visceral hypersensitivity, abnormal intestinal motor function, mucosal immune activation, and increased intestinal permeability concur to its pathophysiology. Psychological factors can influence symptom perception at the central nervous system level. In addition, recent evidence suggests that dysbiosis may be a key pathophysiological factor in patients with IBS. Increasing understanding of the pathophysiological mechanisms translates into new and more effective therapeutic approaches. Indeed, in line with this evidence, IBS therapies nowadays include agents able to modulate gut microbiota function and composition, such as diet, prebiotics, probiotics, and antibiotics. In addition, in the last decade, an increasing interest in fecal microbiota transplantation has been paid. An in-depth understanding of the intestinal microenvironment through accurate faucal microbiota and metabolite analysis may provide valuable insights into the pathophysiology of IBS, finally shaping new tailored IBS therapies.
Sci Rep. 2015 Aug 04;5:12693
[PMID:
26239401]
J Pak Med Assoc. 2007 Jun;57(6):285-7
[PMID:
17629228]
J Gastroenterol Hepatol. 2021 Feb;36(2):446-454
[PMID:
32666516]
Cell. 2014 Mar 27;157(1):121-41
[PMID:
24679531]
Gut. 2017 Jun;66(6):1075-1082
[PMID:
26818616]
Curr Opin Pharmacol. 2018 Dec;43:87-92
[PMID:
30219638]
Gut. 2012 Sep;61(9):1284-90
[PMID:
22234979]
Medicine (Baltimore). 2019 Feb;98(7):e14513
[PMID:
30762787]
Science. 2012 Jun 8;336(6086):1268-73
[PMID:
22674334]
Curr Opin Biotechnol. 2013 Apr;24(2):160-8
[PMID:
22940212]
Neurogastroenterol Motil. 2018 Dec;30(12):e13513
[PMID:
30460770]
Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2986-3000
[PMID:
31002149]
Lancet Gastroenterol Hepatol. 2020 Jul;5(7):658-666
[PMID:
32277872]
Clin Transl Gastroenterol. 2019 Feb;10(2):e00012
[PMID:
30829919]
Dig Liver Dis. 2018 Aug;50(8):741-749
[PMID:
29807873]
Gastroenterology. 2020 Mar;158(4):1016-1028.e8
[PMID:
31843589]
JAMA. 2021 Mar 02;325(9):865-877
[PMID:
33651094]
Adv Immunol. 2014;121:91-119
[PMID:
24388214]
Nat Rev Immunol. 2010 Oct;10(10):735-44
[PMID:
20865020]
Gut. 2017 Apr;66(4):569-580
[PMID:
28087657]
Gastroenterology. 2021 Jan;160(1):99-114.e3
[PMID:
32294476]
Gastroenterology. 2019 Jul;157(1):97-108
[PMID:
30940523]
Gut. 2020 May;69(5):795-796
[PMID:
32102925]
Inflamm Bowel Dis. 2012 Apr;18(4):649-56
[PMID:
21826768]
Gastroenterology. 2020 Aug;159(2):708-738.e4
[PMID:
32531292]
Aliment Pharmacol Ther. 2014 Nov;40(9):1094-102
[PMID:
25175998]
Neurogastroenterol Motil. 2020 Sep;32(9):e13874
[PMID:
32431019]
Gut. 2018 May;67(5):872-881
[PMID:
28416515]
Am J Gastroenterol. 2018 Jan;113(1):86-96
[PMID:
29134969]
Neurogastroenterol Motil. 2012 Jun;24(6):521-30, e248
[PMID:
22339879]
Aliment Pharmacol Ther. 2019 Aug;50(3):240-248
[PMID:
31136009]
Aliment Pharmacol Ther. 2015 Mar;41(5):449-58
[PMID:
25586008]
Gut. 2022 Sep;71(9):1821-1830
[PMID:
34810234]
Am J Gastroenterol. 2012 Feb;107(2):286-95
[PMID:
22068664]
Scand J Gastroenterol. 2003 Oct;38(10):1031-8
[PMID:
14621276]
Immunity. 2015 Nov 17;43(5):845-58
[PMID:
26588778]
Clin Gastroenterol Hepatol. 2012 Jul;10(7):712-721.e4
[PMID:
22426087]
United European Gastroenterol J. 2018 May;6(4):604-613
[PMID:
29881616]
Aliment Pharmacol Ther. 2018 Nov;48(10):1044-1060
[PMID:
30294792]
Gastroenterology. 2016 Dec;151(6):1113-1121
[PMID:
27528177]
Gastroenterol Clin North Am. 2021 Sep;50(3):523-545
[PMID:
34304786]
Gut. 2020 May;69(5):859-867
[PMID:
31852769]
Lancet. 2020 Nov 21;396(10263):1675-1688
[PMID:
33049223]
Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G52-G62
[PMID:
27881403]
Gastroenterology. 2014 Jul;147(1):69-77
[PMID:
24657623]
Am J Gastroenterol. 2018 Sep;113(9):1290-1300
[PMID:
30046155]
Science. 2005 Mar 25;307(5717):1915-20
[PMID:
15790844]
Nature. 2016 Jul 06;535(7610):85-93
[PMID:
27383983]
World J Gastroenterol. 2017 Jul 7;23(25):4491-4499
[PMID:
28740337]
Gastroenterology. 2019 Jan;156(1):46-58.e7
[PMID:
30009817]
Adv Exp Med Biol. 2008;635:15-28
[PMID:
18841700]
Eur J Nutr. 2021 Sep;60(6):3505-3522
[PMID:
33585949]
Cells. 2021 Jun 10;10(6):
[PMID:
34200772]
FEMS Microbiol Rev. 2014 Sep;38(5):996-1047
[PMID:
24861948]
United European Gastroenterol J. 2018 Oct;6(8):1245-1253
[PMID:
30288287]
Environ Microbiol. 2018 Sep;20(9):3201-3213
[PMID:
29749705]
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502
[PMID:
28611480]
PLoS Biol. 2016 Aug 19;14(8):e1002533
[PMID:
27541692]
Science. 2009 Dec 18;326(5960):1694-7
[PMID:
19892944]
Am J Gastroenterol. 2015 Feb;110(2):278-87
[PMID:
25623659]
Cell. 2020 Sep 17;182(6):1460-1473.e17
[PMID:
32916129]
Aliment Pharmacol Ther. 2019 Jul;50(2):132-143
[PMID:
31157418]
Cell Host Microbe. 2019 Oct 9;26(4):527-541.e5
[PMID:
31600503]
Am J Gastroenterol. 2021 Jan 1;116(1):17-44
[PMID:
33315591]
Health Qual Life Outcomes. 2017 Feb 14;15(1):35
[PMID:
28196491]
Gastroenterology. 2017 Jan;152(1):111-123.e8
[PMID:
27725146]
EFSA J. 2021 Jun 11;19(6):e06641
[PMID:
34136006]
Gut. 2021 Jul;70(7):1214-1240
[PMID:
33903147]
N Engl J Med. 2011 Jan 6;364(1):22-32
[PMID:
21208106]
Gastroenterology. 2016 Feb 18;:
[PMID:
27144620]
Gastroenterology. 2016 Feb 19;:
[PMID:
27144617]
Microb Ecol Health Dis. 2015 Feb 02;26:26191
[PMID:
25651997]
J Clin Gastroenterol. 2020 Feb;54(2):175-183
[PMID:
30148765]
Front Nutr. 2021 Sep 13;8:718356
[PMID:
34589512]
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14
[PMID:
24912386]
Am J Gastroenterol. 2002 Jan;97(1):104-8
[PMID:
11808932]
Pain. 2008 Jul;137(1):147-155
[PMID:
17928145]
Gastroenterology. 2016 Feb 18;:
[PMID:
27144627]
Gut. 2018 Jun;67(6):1078-1086
[PMID:
28601847]
Gastroenterology. 2020 Aug;159(2):697-705
[PMID:
32531291]
