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Molecules (Basel, Switzerland)
Feb 05, 2024;29 (3):

Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism.

Tongjia Ni, Shuai Zhang, Jia Rao, Jiaqi Zhao, Haiqi Huang, Ying Liu, Yue Ding, Yaqian Liu, Yuchi Ma, Shoujun Zhang, Yang Gao, Liqian Shen, Chuanbo Ding, Yunpeng Sun
Author Information
  1. Tongjia Ni: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  2. Shuai Zhang: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  3. Jia Rao: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  4. Jiaqi Zhao: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  5. Haiqi Huang: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  6. Ying Liu: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  7. Yue Ding: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  8. Yaqian Liu: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  9. Yuchi Ma: Jilin Aodong Health Technology Co., Ltd., Yanbian 133700, China.
  10. Shoujun Zhang: Jilin Aodong Yanbian Pharmaceutical Co., Ltd., Yanbian 133700, China.
  11. Yang Gao: Jilin Jianwei Natural Biotechnology Co., Ltd., Linjiang 134600, China.
  12. Liqian Shen: Jilin Jianwei Natural Biotechnology Co., Ltd., Linjiang 134600, China.
  13. Chuanbo Ding: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  14. Yunpeng Sun: College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
PMID: 38338482 DOI: 10.3390/molecules29030741

Abstract

Phlorizin, as a flavonoid from a wide range of sources, is gradually becoming known for its biological activity. Phlorizin can exert antioxidant effects by regulating the IL-1β/IKB-α/NF-KB signaling pathway. At the same time, it exerts its antibacterial activity by reducing intracellular DNA agglutination, reducing intracellular protein and energy synthesis, and destroying intracellular metabolism. In addition, phlorizin also has various pharmacological effects such as antiviral, antidiabetic, antitumor, and hepatoprotective effects. Based on domestic and foreign research reports, this article reviews the plant sources, extraction, and biological activities of phlorizin, providing a reference for improving the clinical application of phlorizin.

Keywords

biological activity extraction and identification mechanism phlorizin

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MeSH Term

Phlorhizin
Glucosides
Antioxidants
Flavonoids
Hypoglycemic Agents

Chemicals

Phlorhizin
Glucosides
Antioxidants
Flavonoids
Hypoglycemic Agents
Journal Article Review

Word Cloud

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