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Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
06, 2024;37 (3): 721-737.

Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population.

Manolo Ortega-Romero, Elodia Rojas-Lima, Juan Carlos Rubio-Gutiérrez, Octavio Gamaliel Aztatzi-Aguilar, Juana Narváez-Morales, Mariela Esparza-García, Ángel Barrera-Hernández, Miguel Ángel Mejia, Pablo Mendez-Hernández, Mara Medeiros, Olivier Christophe Barbier
Author Information
  1. Manolo Ortega-Romero: Unidad de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.
  2. Elodia Rojas-Lima: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico.
  3. Juan Carlos Rubio-Gutiérrez: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico.
  4. Octavio Gamaliel Aztatzi-Aguilar: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico.
  5. Juana Narváez-Morales: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico.
  6. Mariela Esparza-García: Unidad de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.
  7. Ángel Barrera-Hernández: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico.
  8. Miguel Ángel Mejia: Fundación Franco-Mexicana Para La Medicina, I.A.P, Ciudad de México, Mexico.
  9. Pablo Mendez-Hernández: Departamento de Calidad y Educación en Salud, Secretaría de Salud de Tlaxcala, Tlaxcala, Mexico.
  10. Mara Medeiros: Unidad de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.
  11. Olivier Christophe Barbier: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico. obarbier@cinvestav.mx.
PMID: 38642266 DOI: 10.1007/s10534-024-00603-3

Abstract

BACKGROUND: In kidney damage, molecular changes can be used as early damage kidney biomarkers, such as Kidney Injury Molecule-1 and Neutrophil gelatinase-associated lipocalin. These biomarkers are associated with toxic metal exposure or disturbed homeostasis of trace elements, which might lead to serious health hazards. This study aimed to evaluate the relationship between exposure to trace elements and early damage kidney biomarkers in a pediatric population.
METHODS: In Tlaxcala, a cross-sectional study was conducted on 914 healthy individuals. The participants underwent a medical review and a socio-environmental questionnaire. Five early damage kidney biomarkers were determined in the urine with Luminex, and molybdenum, copper, selenium, nickel, and iodine were measured with ICP-Mass.
RESULTS: The eGFR showed a median of 103.75 mL/min/1.73 m2. The median levels for molybdenum, copper, selenium, nickel, and iodine were 24.73 ng/mL, 73.35 ng/mL, 4.78 ng/mL, 83.68 ng/mL, and 361.83 ng/mL, respectively. Except for molybdenum and nickel, the other trace elements had significant associations with the eGFR and the early kidney damage biomarkers. Additionally, we report the association of different exposure scenarios with renal parameters.
DISCUSSION: and Conclusions. Among the explored metals, exposure to Cu and iodine impairs renal function. In contrast, Se may manifest as a beneficial metal. Interactions of Mo-Se and Mo-Iodine seem to alter the expression of NGAL; Mo-Cu for CLU; Mo-Cu, Mo-Se, and Mo-iodine for Cys-C and a-1MG; and Mo-Cu and Mo-iodine for KIM-1; were noticed. Our study could suggest that trace element interactions were associated with early kidney damage biomarkers.

Keywords

Early kidney damage biomarkers Estimated Glomerular Filtration Rate Kidney disease Trace elements

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Grants

  1. 558205/Conahcyt
  2. 272556/Conahcyt
  3. 701988/Conahcyt
  4. Pronaii 321320/Conahcyt

MeSH Term

Humans
Biomarkers
Child
Male
Female
Trace Elements
Environmental Exposure
Cross-Sectional Studies
Adolescent
Lipocalin-2
Glomerular Filtration Rate
Copper
Selenium
Kidney Diseases
Kidney
Child, Preschool
Nickel
Journal Article Research Support, Non-U.S. Gov't

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