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Environmental health perspectives
May, 2024;132 (5): 57010.

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.

Danielle E McBride, Amit Bhattacharya, Heidi Sucharew, Kelly J Brunst, Mary Barnas, Cyndy Cox, Lorenna Altman, Timothy J Hilbert, Jeff Burkle, Susan Westneat, Kaitlin Vollet Martin, Patrick J Parsons, Meredith L Praamsma, Christopher D Palmer, Kurunthachalam Kannan, Donald R Smith, Robert Wright, Chitra Amarasiriwardena, Kim N Dietrich, Kim M Cecil, Erin N Haynes
Author Information
  1. Danielle E McBride: Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA. ORCID
  2. Amit Bhattacharya: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  3. Heidi Sucharew: Department of Emergency Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  4. Kelly J Brunst: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  5. Mary Barnas: Department of Psychology, Marietta College, Marietta, Ohio, USA.
  6. Cyndy Cox: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  7. Lorenna Altman: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  8. Timothy J Hilbert: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  9. Jeff Burkle: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  10. Susan Westneat: Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
  11. Kaitlin Vollet Martin: Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
  12. Patrick J Parsons: Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  13. Meredith L Praamsma: Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  14. Christopher D Palmer: Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  15. Kurunthachalam Kannan: Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  16. Donald R Smith: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.
  17. Robert Wright: Environmental Medicine and Public Health, Mount Sinai School of Medicine, New York, New York, USA.
  18. Chitra Amarasiriwardena: Environmental Medicine and Public Health, Mount Sinai School of Medicine, New York, New York, USA.
  19. Kim N Dietrich: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  20. Kim M Cecil: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  21. Erin N Haynes: Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
PMID: 38780454 DOI: 10.1289/EHP13381

Abstract

BACKGROUND: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance.
OBJECTIVES: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort.
METHODS: Participants were recruited into CARES when they were 7-9 y old, and reenrolled at 13-18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height-weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine.
RESULTS: CARES participants who completed the adolescent postural balance assessment () were 98% White and 54% female and had a mean age of 16 y (range: 13-18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males.
DISCUSSION: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. https://doi.org/10.1289/EHP13381.

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Grants

  1. P30 ES006096/NIEHS NIH HHS
  2. T32 ES010957/NIEHS NIH HHS
  3. T42 OH008432/NIOSH CDC HHS
  4. R24 ES030904/NIEHS NIH HHS
  5. R01 ES016531/NIEHS NIH HHS
  6. R01 ES026446/NIEHS NIH HHS

MeSH Term

Humans
Adolescent
Biomarkers
Manganese
Female
Male
Child
Postural Balance
Hair
Nails
Cohort Studies
Environmental Exposure
Lead
Longitudinal Studies
Cotinine
Environmental Pollutants

Chemicals

Biomarkers
Manganese
Lead
Cotinine
Environmental Pollutants
Journal Article

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