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Trends in genetics : TIG
Aug, 2024;40 (8): 718-729.

Epigenome-metabolism nexus in the retina: implications for aging and disease.

Anupam K Mondal, Mohita Gaur, Jayshree Advani, Anand Swaroop
Author Information
  1. Anupam K Mondal: Neurobiology, Neurodegeneration, and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  2. Mohita Gaur: Neurobiology, Neurodegeneration, and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  3. Jayshree Advani: Neurobiology, Neurodegeneration, and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  4. Anand Swaroop: Neurobiology, Neurodegeneration, and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: swaroopa@nei.nih.gov.
PMID: 38782642 DOI: 10.1016/j.tig.2024.04.012

Abstract

Intimate links between epigenome modifications and metabolites allude to a crucial role of cellular metabolism in transcriptional regulation. Retina, being a highly metabolic tissue, adapts by integrating inputs from genetic, epigenetic, and extracellular signals. Precise global epigenomic signatures guide development and homeostasis of the intricate retinal structure and function. Epigenomic and metabolic realignment are hallmarks of aging and highlight a link of the epigenome-metabolism nexus with aging-associated multifactorial traits affecting the retina, including age-related macular degeneration and glaucoma. Here, we focus on emerging principles of epigenomic and metabolic control of retinal gene regulation, with emphasis on their contribution to human disease. In addition, we discuss potential mitigation strategies involving lifestyle changes that target the epigenome-metabolome relationship for maintaining retinal function.

Keywords

DNA methylation age-related macular degeneration diet environmental factors gene regulation histone modifications metabolic pathways multifactorial traits vision impairment

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Grants

  1. Z01 EY000450/Intramural NIH HHS
  2. ZIA EY000450/Intramural NIH HHS
  3. ZIA EY000546/Intramural NIH HHS

MeSH Term

Humans
Aging
Epigenome
Retina
Epigenesis, Genetic
Macular Degeneration
Animals
Gene Expression Regulation
Epigenomics
Glaucoma
DNA Methylation
Journal Article Review

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