Impact of Selective Reporting of Antibiotic Susceptibility Test Results on Antibiotic Use in Patients with Bloodstream Infection with .

Florian Geismann, Kathleen Brueckner, Michael Pfeifer, Bernd Salzberger, Stilla Bauernfeind, Florian Hitzenbichler, Michaela Simon, Aila Caplunik-Pratsch, Wulf Schneider-Brachert, Clemens Wiest, Thilo Hinterberger, Tamara Ruegamer, Arno Mohr
Author Information
  1. Florian Geismann: Center for Pneumonology, Donaustauf Hospital, Donaustauf, Germany.
  2. Kathleen Brueckner: Center for Pneumonology, Donaustauf Hospital, Donaustauf, Germany.
  3. Michael Pfeifer: Center for Pneumonology, Donaustauf Hospital, Donaustauf, Germany.
  4. Bernd Salzberger: Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
  5. Stilla Bauernfeind: Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
  6. Florian Hitzenbichler: Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
  7. Michaela Simon: Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
  8. Aila Caplunik-Pratsch: Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
  9. Wulf Schneider-Brachert: Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
  10. Clemens Wiest: Department of Internal Medicine 2, University Hospital Regensburg, Regensburg, Germany.
  11. Thilo Hinterberger: Department of Psychosomatic Medicine, University Hospital Regensburg, Regensburg, Germany.
  12. Tamara Ruegamer: Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
  13. Arno Mohr: Center for Pneumonology, Donaustauf Hospital, Donaustauf, Germany.

Abstract

Introduction: Invasive pneumococcal disease is a major cause of morbidity and mortality in infectious diseases. Selective reporting of antibiotic susceptibility test results might lead to a tailored antibiotic therapy and could therefore be an important antibiotic stewardship program intervention. The aim of this study was to analyse whether a switch to selective reporting of antibiotic test results leads to a more focused antibiotic therapy in patients with a bloodstream infection with .
Methods: This study was performed as a retrospective cohort study at the University Hospital Regensburg, Germany. All blood cultures positive for between 2006 and 2021 were analysed. In 2014, a switch to selective reporting of antibiotic susceptibility test results omitting sensitivity results for agents not recommended was introduced.
Results: Twenty-four hours after final antibiotic susceptibility test results were available, 20.9% before (BI) versus 15.4% after implementation (AI) of selective reporting of antibiotic test results received a narrow-spectrum penicillin, while only 2.3% BI versus 5.8% AI received a narrow-spectrum penicillin from the beginning.
Conclusion: Selective reporting of antibiotic susceptibility test results without further antimicrobial stewardship interventions did not lead to a higher use of a narrow-spectrum penicillin in this study.

Keywords

References

Eur J Hosp Pharm. 2022 Mar;29(2):79-83 [PMID: 35190452]
Clin Microbiol Infect. 2021 Apr;27(4):568-575 [PMID: 33059090]
Expert Rev Anti Infect Ther. 2020 Mar;18(3):251-262 [PMID: 31928257]
Infection. 2023 Oct;51(5):1557-1562 [PMID: 37217812]
Int J Antimicrob Agents. 2017 Feb;49(2):162-166 [PMID: 28093208]
Respir Med. 2020 Nov - Dec;174:106207 [PMID: 33152552]
Internist (Berl). 2015 Nov;56(11):1264-70 [PMID: 26482078]
Lancet Infect Dis. 2018 Nov;18(11):1191-1210 [PMID: 30243584]
Infect Control Hosp Epidemiol. 2021 Oct;42(10):1272-1274 [PMID: 33423705]
Intensive Care Med. 2020 Jul;46(7):1404-1417 [PMID: 32519003]
J Chemother. 2022 Sep;34(5):311-318 [PMID: 35193457]
Clin Microbiol Infect. 2021 Apr;27(4):503-505 [PMID: 33253937]
Infection. 2016 Jun;44(3):395-439 [PMID: 27066980]
Infection. 2021 Dec;49(6):1319-1323 [PMID: 34618306]
Antimicrob Resist Infect Control. 2021 Nov 6;10(1):157 [PMID: 34742320]
Med Klin Intensivmed Notfmed. 2021 Feb;116(1):81-92 [PMID: 33108477]

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