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Epigenetics & chromatin
Jul 31, 2024;17 (1): 23.

The role of ribosomal DNA methylation in embryonic development, aging and diseases.

Fei Yang, Xutong Guo, Yiming Bao, Rujiao Li
Author Information
  1. Fei Yang: National Genomics Data Center, China National Center for Bioinformation, Beijing, 100101, China.
  2. Xutong Guo: National Genomics Data Center, China National Center for Bioinformation, Beijing, 100101, China.
  3. Yiming Bao: National Genomics Data Center, China National Center for Bioinformation, Beijing, 100101, China. baoym@big.ac.cn.
  4. Rujiao Li: National Genomics Data Center, China National Center for Bioinformation, Beijing, 100101, China. lirj@big.ac.cn.
PMID: 39085958 DOI: 10.1186/s13072-024-00548-4

Abstract

The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleolus, and responsible for coding three major types of rRNAs (18S, 5.8S and 28S). While historical investigations into rDNA focused on its structure and coding capabilities, recent research has turned to explore its functional roles in various biological processes. In this review, we summarize the main findings of rDNA methylation with embryonic development, aging and diseases in multiple species, including epigenetic alterations, related biological processes and potential applications of rDNA methylation. We present an overview of current related research and identify gaps in this field.

Keywords

Aging Disease Embryonic development Methylation rDNA

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Grants

  1. 32300468/National Natural Science Foundation of China

MeSH Term

Humans
DNA Methylation
Embryonic Development
Animals
Aging
DNA, Ribosomal
Epigenesis, Genetic

Chemicals

DNA, Ribosomal
Journal Article Review
Article has an altmetric score of 1

Word Cloud

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