Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs. - National Genomics Data Center (CNCB-NGDC)

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Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.

Kasey L Rigby, Michael J Diaz, Etienne C Gozlan, Dorottya B Kacsoh, Joanna J Song, Tabitha R Hudock, Andrea Chobrutskiy, Boris I Chobrutskiy, George Blanck

Author Information

Kasey L Rigby: University of Central Florida College of Medicine, Orlando, FL, U.S.A.
Michael J Diaz: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
Etienne C Gozlan: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
Dorottya B Kacsoh: University of Central Florida College of Medicine, Orlando, FL, U.S.A.
Joanna J Song: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
Tabitha R Hudock: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
Andrea Chobrutskiy: Department of Pediatrics, Oregon Health and Science University Hospital, Portland, OR, U.S.A.
Boris I Chobrutskiy: Department of Internal Medicine, Oregon Health and Science University Hospital, Portland, OR, U.S.A.
George Blanck: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.; gblanck@usf.edu.

PMID: 39191494 DOI: 10.21873/cgp.20462

BACKGROUND/AIM: Wilms' tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival.
MATERIALS AND METHODS: We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms' tumor.
RESULTS: T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms' tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms' tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes.
CONCLUSION: Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections.

RNAseq files T-cell receptor Wilms’ tumor complementarity determining region-3 cytomegalovirus

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Humans

Wilms Tumor

Complementarity Determining Regions

Receptors, Antigen, T-Cell

Kidney Neoplasms

Cytomegalovirus

Cytomegalovirus Infections

Prognosis

Epitopes

Complementarity Determining Regions

Receptors, Antigen, T-Cell

Epitopes

Journal Article