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Nucleic acids research
Jan 06, 2025;53 (D1): D1047-D1054.

Immunosenescence Inventory-a multi-omics database for immune aging research.

Hao Li, Wei Zhao, Fei Yang, Qin Qiao, Shuai Ma, Kuan Yang, Shuhui Song, Si Wang, Jing Qu, Guang-Hui Liu, Yiming Bao, Weiqi Zhang
Author Information
  1. Hao Li: China National Center for Bioinformation, Beijing 100101, China.
  2. Wei Zhao: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
  3. Fei Yang: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
  4. Qin Qiao: China National Center for Bioinformation, Beijing 100101, China.
  5. Shuai Ma: University of Chinese Academy of Sciences, Beijing 100049, China.
  6. Kuan Yang: China National Center for Bioinformation, Beijing 100101, China.
  7. Shuhui Song: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. ORCID
  8. Si Wang: Aging Biomarker Consortium, Beijing 100101, China.
  9. Jing Qu: University of Chinese Academy of Sciences, Beijing 100049, China. ORCID
  10. Guang-Hui Liu: University of Chinese Academy of Sciences, Beijing 100049, China. ORCID
  11. Yiming Bao: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
  12. Weiqi Zhang: China National Center for Bioinformation, Beijing 100101, China. ORCID
PMID: 39673270 DOI: 10.1093/nar/gkae1102

Abstract

The immune system is intricately interconnected with all other bodily systems. As individuals age, the immune system undergoes changes known as immunosenescence, increasing susceptibility to disease, and contributing significantly to the morbidity and mortality observed in older populations. Immunosenescence drives systemic aging and therefore represents a key therapeutic target to extend healthy aging. In recent years, the extensive application of omics technologies has broadened our understanding of aging and immunity, necessitating a comprehensive database to encapsulate these advancements and deepen our insights into immune aging in the era of artificial intelligence. The Immunosenescence Inventory is a pioneering database designed to provide a multidimensional and integrative view of the aging immune system. By leveraging cutting-edge omics technologies and analytical tools, Immunosenescence Inventory offers a comprehensive resource for researchers to explore the intricate relationship between immunosenescence and age-related health outcomes. Furthermore, the database, which aids in the creation of diagnostic tools for immune aging conditions, is now publicly available at https://ngdc.cncb.ac.cn/iaa/home.

Grants

  1. 32121001/National Natural Science Foundation of China
  2. 2022YFA1103700/National Key Research and Development Program of China
  3. YSBR-076/CAS Project for Young Scientists in Basic Research
  4. Z230011/Beijing Natural Science Foundation
  5. CAS-WX2022SDC-XK14/Chinese Academy of Sciences
  6. 2021-1045/XPLORER PRIZE
  7. 2022083/Youth Innovation Promotion Association of CAS
  8. JYY2023-13/Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes
  9. 12300927/CAS Youth Interdisciplinary Team, Excellent Young Talents Program of Capital Medical University
  10. 11000023T000002036310/Project for Technology Development of Beijing-affiliated Medical Research Institutes
  11. BPHR202203105/Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team
  12. 2021QNRC001/CAST
  13. 2023IOZ0102/Chinese Academy of Sciences
  14. 2021YFF0703700/National Key Research and Development Program of China
  15. CAS-WX2022SDC-XK05/Genomics Data Center Operation and Maintenance of Chinese Academy of Sciences

MeSH Term

Humans
Immunosenescence
Aging
Databases, Factual
Genomics
Immune System
Proteomics
Multiomics
Journal Article

Links to CNCB-NGDC Resources

Database Commons: DBC009974 (Immunosenescence Inventory)

Word Cloud

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