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Journal of medical virology
Dec, 2024;96 (12): e70141.

Risk of Uveitis in Dengue Fever Patients: A Population-Based Cohort Study in Taiwan.

Bing-Qi Wu, Hou-Ting Kuo, Alan Y Hsu, Chun-Ju Lin, Peng-Tai Tien, Ning-Yi Hsia, Yih-Dih Cheng, Yow-Wen Hsieh, Yu-Han Huang, Sing-Ting Wang, Chun-Ting Lai, Yi-Ching Shao, Chun-Chi Chiang, Hsin Tseng, Huan-Sheng Chen, Yi-Yu Tsai
Author Information
  1. Bing-Qi Wu: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  2. Hou-Ting Kuo: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  3. Alan Y Hsu: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  4. Chun-Ju Lin: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan. ORCID
  5. Peng-Tai Tien: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  6. Ning-Yi Hsia: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  7. Yih-Dih Cheng: Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan.
  8. Yow-Wen Hsieh: Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan.
  9. Yu-Han Huang: Department of Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
  10. Sing-Ting Wang: Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
  11. Chun-Ting Lai: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  12. Yi-Ching Shao: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  13. Chun-Chi Chiang: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  14. Hsin Tseng: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  15. Huan-Sheng Chen: An-Shin Dialysis Center, Excelsior Renal Service Co. Ltd. Taiwan Branch, Taichung, Taiwan.
  16. Yi-Yu Tsai: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
PMID: 39707739 DOI: 10.1002/jmv.70141

Abstract

Dengue-related ocular complications were considered rare, but recent evidence points to a broader spectrum of manifestations, including uveitis. This study utilized the Taiwan National Health Insurance Research Database (NHIRD) to investigate the incidence of uveitis in dengue patients, aiming to fill this research gap. This population-based, retrospective cohort study utilized the Taiwan National Health Insurance Research Database (NHIRD) and included patients with and without Dengue fever. The non-Dengue fever cohort comprised randomly selected control patients who were matched. Hazard ratios and Kaplan-Meier analysis were conducted to compare the incidence of uveitis in the Dengue and non-Dengue cohorts. Subgroup analyses were carried out based on age groups, genders, and comorbidities. A total of 26 950 patients diagnosed with Dengue fever were included in the study (49.6% female, mean age at index 41.63 years). Based on a 1:4 matching ratio, 107 800 control subjects without uveitis (50.03% female, mean age at index 41.41 years) were also included. The adjusted hazard ratio (aHR) of uveitis was higher in the Dengue fever group than in the non-Dengue fever group (aHR = 1.38, p < 0.001). A history of stroke or transient ischemic attack (TIA) was not associated with uveitis. Stratified analyses revealed that patients with Dengue fever had an increased risk regardless of their sex and age. The Kaplan-Meier method with the log-rank test showed a significantly higher cumulative incidence of uveitis in the Dengue fever cohort than in the non-Dengue fever cohort (p < 0.001). In the subgroup analysis for most major comorbidities, the significantly higher risk for uveitis in those patients with Dengue fever, was only demonstrated in the subgroups of those without these major comorbidities. Our findings showed Dengue infection to be associated with increased risk for uveitis. Clinicians should be attentive to a history of stroke or TIA in patients with Dengue fever.

Keywords

arboviral disease dengue fever stroke transient ischemic attack uveitis

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Grants

  1. /The authors received no specific funding for this work.

MeSH Term

Humans
Taiwan
Male
Female
Dengue
Adult
Retrospective Studies
Uveitis
Middle Aged
Incidence
Young Adult
Aged
Risk Factors
Adolescent
Child
Comorbidity
Child, Preschool
Proportional Hazards Models
Infant
Aged, 80 and over
Journal Article

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