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Journal of cancer prevention
Dec 30, 2024;29 (4): 120-128.

Shiga Toxin: Emerging Producer Strains, Prophylactic Approaches, and Application in Cancer Therapy.

Kiandokht Babolhavaeji, Amjad Ahmadi, Leili Shokoohizadeh
Author Information
  1. Kiandokht Babolhavaeji: Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. ORCID
  2. Amjad Ahmadi: Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. ORCID
  3. Leili Shokoohizadeh: Infectious Disease Research Center, Avicenna Institute of Clinical Sciences, Hamadan, IranAvicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran. ORCID
PMID: 39790227 DOI: 10.15430/JCP.24.010

Abstract

Shiga toxin-producing is the most prevalent bacterial strain responsible for Shiga toxin-related infections. While Shiga toxin is inherently toxic, it has potential therapeutic applications as a component of anticancer drugs. Despite its association with infections and harmful effects on human health, Shiga toxin is being explored as a viable element in drug delivery systems targeting cancer cells. The findings indicate that the production of mutated bacteria containing Shiga toxin is an effective preventive strategy for immunization against these toxins. Furthermore, the B subunit of Shiga toxin shows promise for imaging cancer cells, opening new paths for therapeutic interventions.

Keywords

Cancer Escherichia coli Shiga toxin

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