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Esophagus : official journal of the Japan Esophageal Society
Jul, 2025;22 (3): 279-288.

Nutritional management during chemotherapy and chemoradiotherapy for advanced esophageal cancer.

Yutaka Kimura, Atsushi Gakuhara, Shuichi Fukuda, Yasunari Fukuda, Terukazu Yoshihara, Chikato Koga, Naotsugu Haraguchi, Jin-Ichi Hida
Author Information
  1. Yutaka Kimura: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan. you_kimura@aol.com. ORCID
  2. Atsushi Gakuhara: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
  3. Shuichi Fukuda: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
  4. Yasunari Fukuda: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
  5. Terukazu Yoshihara: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
  6. Chikato Koga: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
  7. Naotsugu Haraguchi: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
  8. Jin-Ichi Hida: Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
PMID: 40155587 DOI: 10.1007/s10388-025-01117-8

Abstract

Advanced esophageal cancer is treated by chemotherapy, radiation therapy, chemoradiotherapy, and immunotherapy. However, the stenosis caused by the tumor and cancer-related chronic inflammation leads to inadequate food intake, weight loss, and nutrition problems. Given that poor pre-treatment nutritional status increases the risks of treatment-related adverse events and a poor prognosis, the nutrition guidelines recommend a pre-treatment nutritional assessment. When malnutrition is present, nutritional interventions, such as dietary guidance and enteral nutrition supplements, provided by the medical team may reduce treatment-related adverse events. However, whether nutritional intervention improves the prognosis is a topic for future research, including randomized controlled trials. This review discusses the literature on nutritional management in patients undergoing chemotherapy and chemoradiotherapy for advanced esophageal cancer.

Keywords

Advanced esophageal cancer Chemoradiation Chemotherapy Nutritional assessment Nutritional intervention

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MeSH Term

Humans
Esophageal Neoplasms
Chemoradiotherapy
Nutritional Status
Malnutrition
Enteral Nutrition
Nutrition Assessment
Nutritional Support
Prognosis
Journal Article Review

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