Ting-Ting Sun, Xue-Guo Sun, Ti-Dong Shan, Peng Zhao, Yan-Yan Lu, Qian Li, Fu-Guo Liu
Background: Castleman disease (CD) is a relatively rare benign lymphoproliferative disorder of the lymphoid tissue. According to clinical manifestations, it is classified into two types: unicentric CD (UCD) and multicentric CD (MCD). Pathological subtypes include hyaline-vascular (HV), plasma cell (PC), and mixed (MV). Gastrointestinal CD is extremely rare, and limited information is available regarding its clinical presentation and management.
Case Summary: We report a case of a patient who presented with paroxysmal epigastric pain for 4 years. Laboratory tests showed no remarkable abnormalities, whereas CT revealed endogenous occupancy on the side of the greater curvature of the stomach. Ultrasonographic endoscopy demonstrated hypoechoic, well-defined foci. The lesion initially suspected to be an inflammatory fibroma was subsequently pathologically confirmed as HV-UCD following endoscopic submucosal dissection. The lesion was completely resected, and the patient showed no signs of recurrence during 7 months of follow-up.
Conclusion: Gastrointestinal CD is rare and should be differentiated from other occupying lesions. Its definitive diagnosis relies on histopathology.
Blood. 2019 Apr 18;133(16):1720-1728
[PMID:
30760451]
Acta Chir Belg. 2009 Mar-Apr;109(2):240-1
[PMID:
19499690]
Eur J Dermatol. 2002 Jul-Aug;12(4):355-9
[PMID:
12095881]
Ulus Travma Acil Cerrahi Derg. 2020 Jan;26(1):144-147
[PMID:
31942736]
Pathol Res Pract. 2006;202(7):541-8
[PMID:
16564140]
J Lab Physicians. 2019 Apr-Jun;11(2):171-173
[PMID:
31160859]
AJR Am J Roentgenol. 2004 Mar;182(3):769-75
[PMID:
14975984]
Semin Oncol. 1993 Dec;20(6):636-47
[PMID:
8296200]
Hematol Oncol Clin North Am. 2018 Feb;32(1):65-73
[PMID:
29157620]
Blood. 2020 Apr 16;135(16):1353-1364
[PMID:
32106302]
Blood. 2018 Nov 15;132(20):2115-2124
[PMID:
30181172]
Pathol Oncol Res. 2013 Jul;19(3):345-51
[PMID:
23516126]
Cureus. 2024 Jul 19;16(7):e64935
[PMID:
39161530]
Am J Gastroenterol. 1990 Sep;85(9):1179-81
[PMID:
2389730]
Zhonghua Xue Ye Xue Za Zhi. 2019 Jan 14;40(1):52-57
[PMID:
30704229]
Yonsei Med J. 2005 Apr 30;46(2):289-91
[PMID:
15861504]
Br J Radiol. 2015 May;88(1049):20140670
[PMID:
25710283]
Radiographics. 2011 Oct;31(6):1793-807
[PMID:
21997995]
Urology. 1993 Feb;41(2):162-4
[PMID:
8497992]
Blood. 2017 Mar 23;129(12):1646-1657
[PMID:
28087540]
World J Clin Cases. 2019 Dec 26;7(24):4391-4397
[PMID:
31911923]
Cancer. 1972 Mar;29(3):670-83
[PMID:
4551306]
Clin Nucl Med. 2013 May;38(5):339-42
[PMID:
23429387]
Eur J Haematol. 2021 Oct;107(4):484-488
[PMID:
34242421]
Quant Imaging Med Surg. 2024 Oct 1;14(10):7749-7752
[PMID:
39429597]
Clin Infect Dis. 2013 Mar;56(6):833-42
[PMID:
23223599]
Endosc Ultrasound. 2014 Apr;3(Suppl 1):S10-1
[PMID:
26425506]
ACG Case Rep J. 2017 May 24;4:e71
[PMID:
28584844]
J Comput Assist Tomogr. 2001 Mar-Apr;25(2):207-14
[PMID:
11242214]
Lancet Reg Health West Pac. 2023 Mar 24;34:100720
[PMID:
37283978]
Pathology. 2023 Aug;55(5):703-707
[PMID:
36907779]
Blood. 2013 Dec 19;122(26):4189-98
[PMID:
24174627]
Gut. 1992 Jan;33(1):135-7
[PMID:
1740268]
Ann Intern Med. 1998 Apr 15;128(8):657-62
[PMID:
9537940]
Dis Colon Rectum. 2007 Mar;50(3):389-94
[PMID:
17171476]
Int J STD AIDS. 2006 Jan;17(1):19-24; quiz 25
[PMID:
16409673]
Gastroenterology. 2013 Apr;144(4):e5-6
[PMID:
23462130]
