Os07g0558500 - Revision history

Xysj2012: /* Structured Information */

2015-06-12T08:45:42Z

‎Structured Information

Lxzlxz at 06:44, 10 June 2014

2014-06-10T06:44:21Z

Princehao at 13:33, 9 June 2014

2014-06-09T13:33:35Z

Princehao at 13:29, 9 June 2014

2014-06-09T13:29:46Z

Lxzlxz at 13:22, 9 June 2014

2014-06-09T13:22:20Z

Lxzlxz at 13:19, 9 June 2014

2014-06-09T13:19:23Z

Liuq036 at 13:16, 9 June 2014

2014-06-09T13:16:29Z

Liuq036: /* Knowledge Extension */

2014-06-09T13:15:52Z

‎Knowledge Extension

Liuq036: /* Mutation */

2014-06-09T13:15:10Z

‎Mutation

Liuq036: /* Mutation */

2014-06-09T13:14:55Z

‎Mutation

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 ==Structured Information==
 [[Category:Genes]]
 [[Category:Japonica mRNA]]

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 *Arabidopsis THF1 is reportedly involved in PSII activity, particularly under photo-inhibitory light conditions. In fact, light-dependent D1 degradation, which is mediated by FtsH protease in the PSII repair cycle, was shown to be impaired in the thf1 mutant. Degradation of photo-damaged D1 involves several proteases, among which FtsH plays a central role as a processive enzyme. Interestingly, lack of THF1 leads to a concomitant decrease in FtsH in chloroplasts, suggesting connectivity between THF1 and FtsH. Although physical interaction of the two proteins was not reported, these data, together with the fact that THF1 is associated with PSII, suggest that THF1 is involved in PSII maintenance through protein degradation.
 *SGR is a regulator of chlorophylldegrading activity in vivo. Degradation of LHCII during senescence requires the function of the Chl b reductases NYC1 and NOL, suggesting that Chl b breakdown is necessary for LHCII degradation. Similarly, PSI and Lhca proteins were retained at high levels in sgr-2, suggesting that degradation of PSI and Lhca proteins depends on breakdown of chlorophyll, probably Chl a, because both PSI and Lhca proteins are degraded in Chl b reductase mutants during senescence.
 ==Labs working on this gene==

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 *Ionizing radiation often induces chromosomal rearrangements such as inversions and translocations, which cause gene disruptions or, in some cases, gene fusions. In most cases, these mutations are loss-of-function and recessive; however, both loss-of-function and gain-of-function mutations are possible for gene fusions. Theoretically, these mutations may involve two gene mutations associated with two chromosomal breakpoints.Reports of map-based cloning of mutant genes caused by such mutations are rare, probably because of the difficulty in applying map-based cloning procedures to such a situation. For example, for an inversion, it is very difficult to narrow down the candidate region because recombination is suppressed in the inverted region.
 *Arabidopsis THF1 is reportedly involved in PSII activity, particularly under photo-inhibitory light conditions. In fact, light-dependent D1 degradation, which is mediated by FtsH protease in the PSII repair cycle, was shown to be impaired in the thf1 mutant. Degradation of photo-damaged D1 involves several proteases, among which FtsH plays a central role as a processive enzyme. Interestingly, lack of THF1 leads to a concomitant decrease in FtsH in chloroplasts, suggesting connectivity between THF1 and FtsH. Although physical interaction of the two proteins was not reported, these data, together with the fact that THF1 is associated with PSII, suggest that THF1 is involved in PSII maintenance through protein degradation.
 ==Labs working on this gene==

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 *The nyc4-1 mutation was induced by a translocation-related chromosomal rearrangement
 *The nyc4-1 was obtained from a rice (Oryza sativa L. cv. Nipponbare) M2 population derived from seeds irradiated with carbon ion beams (200 MeV). For dark-induced senescence, detached leaves were incubated in water at 28ºC.
 [[File:111111111.jpg]]
 *Figure 1  A comparison between Nipponbare and nyc4-1 mRNAs in pre-senescent (0 DAD) and senescent (3, 5 and 8 DAD) leaves revealed that expression of Os07g0558500, which is located within the mapped region of chromosome 7, was drastically reduced in nyc4-1.

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 ===Knowledge Extension===
-*Ionizing radiation often induces chromosomal rearrangements such as inversions and translocations, which cause gene disruptions or, in some cases, gene fusions. In most cases, these mutations are loss-of-function and recessive; however, both loss-of-function and gain-of-function mutations are possible for gene fusions. Theoretically, these mutations may involve two gene mutations associated with two chromosomal breakpoints.
+*Ionizing radiation often induces chromosomal rearrangements such as inversions and translocations, which cause gene disruptions or, in some cases, gene fusions. In most cases, these mutations are loss-of-function and recessive; however, both loss-of-function and gain-of-function mutations are possible for gene fusions. Theoretically, these mutations may involve two gene mutations associated with two chromosomal breakpoints.Reports of map-based cloning of mutant genes caused by such mutations are rare, probably because of the difficulty in applying map-based cloning procedures to such a situation. For example, for an inversion, it is very difficult to narrow down the candidate region because recombination is suppressed in the inverted region.
 *Arabidopsis THF1 is reportedly involved in PSII activity, particularly under photo-inhibitory light conditions. In fact, light-dependent D1 degradation, which is mediated by FtsH protease in the PSII repair cycle, was shown to be impaired in the thf1 mutant. Degradation of photo-damaged D1 involves several proteases, among which FtsH plays a central role as a processive enzyme. Interestingly, lack of THF1 leads to a concomitant decrease in FtsH in chloroplasts, suggesting connectivity between THF1 and FtsH. Although physical interaction of the two proteins was not reported, these data, together with the fact that THF1 is associated with PSII, suggest that THF1 is involved in PSII maintenance through protein degradation.

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 ==Annotated Information==
 ===Function===
 *NYC4 encodes the ortholog of Arabidopsis THF1. nyc4 retained chlorophyll during senescence, although changes in other senescence parameters indicated that senescence proceeded, suggesting that nyc4 is a non-functional stay-green mutant.
 *In nyc4, the Fv/Fm value, which reflects PSII activity, remains at a high level during senescence. This is a very different characteristic from those observed in the non-functional stay-green mutants sgr and nyc3