Os09g0114500 - Revision history

Rice2012: /* Structured Information */

2015-06-12T09:37:42Z

‎Structured Information

HamletShaoE at 13:35, 25 May 2014

2014-05-25T13:35:10Z

HamletShaoE: /* Function */

2014-05-25T13:34:48Z

‎Function

Xysj2012: /* Knowledge Extension */

2013-04-05T12:53:34Z

‎Knowledge Extension

Xysj2012: /* Expression */

2013-04-04T09:33:38Z

‎Expression

Xysj2012: /* Knowledge Extension */

2013-04-04T09:31:52Z

‎Knowledge Extension

Xysj2012: /* References */

2013-04-04T09:30:26Z

‎References

Xysj2012: /* References */

2013-04-04T09:30:13Z

‎References

Xysj2012: /* Labs working on this gene */

2013-04-04T09:29:45Z

‎Labs working on this gene

Xysj2012 at 09:28, 4 April 2013

2013-04-04T09:28:51Z

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 ==Structured Information==
 [[Category:Genes]]
 [[Category:Japonica mRNA]]

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 ===Function===
 '''''BC12''''' plays an important role in cell-cycle progression, cellulose microfibril deposition and wall composition in the monocot plant rice<ref name="ref1" />. This gene encodes a kinesin-like protein with transcription regulation activity, which can mediate cell elongation by regulating the expression of the '''''KO2''''' gene in the GA biosynthesis pathway<ref name="ref2" />. It is also likely to be a good subject for exploring the link between cell growth and cell wall formation in rice<ref name="ref1" />.<br><br>
-'''GO assignment(s):''' [http://amigo.geneontology.org/amigo/term/GO:0003777 GO:0003777, [http://amigo.geneontology.org/amigo/term/GO:0005524 GO:0005524], [http://amigo.geneontology.org/amigo/term/GO:0005875 GO:0005875], [http://amigo.geneontology.org/amigo/term/GO:0007018 GO:0007018]
+'''GO assignment(s):''' [http://amigo.geneontology.org/amigo/term/GO:0003777 GO:0003777], [http://amigo.geneontology.org/amigo/term/GO:0005524 GO:0005524], [http://amigo.geneontology.org/amigo/term/GO:0005875 GO:0005875], [http://amigo.geneontology.org/amigo/term/GO:0007018 GO:0007018]
 ===Mutation===

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 ===Function===
 '''''BC12''''' plays an important role in cell-cycle progression, cellulose microfibril deposition and wall composition in the monocot plant rice<ref name="ref1" />. This gene encodes a kinesin-like protein with transcription regulation activity, which can mediate cell elongation by regulating the expression of the '''''KO2''''' gene in the GA biosynthesis pathway<ref name="ref2" />. It is also likely to be a good subject for exploring the link between cell growth and cell wall formation in rice<ref name="ref1" />.<br><br>
-'''GO assignment(s):''' GO:0003777, GO:0005524, GO:0005875, GO:0007018
+'''GO assignment(s):''' [http://amigo.geneontology.org/amigo/term/GO:0003777 GO:0003777, [http://amigo.geneontology.org/amigo/term/GO:0005524 GO:0005524], [http://amigo.geneontology.org/amigo/term/GO:0005875 GO:0005875], [http://amigo.geneontology.org/amigo/term/GO:0007018 GO:0007018]
 ===Mutation===

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 ===Knowledge Extension===
-* [http://en.wikipedia.org/wiki/Gibberellins  Gibberellins (GAs)] are one of the most important endogenous growth regulators in plants<ref name="ref2" /><ref name="ref3" /><ref name="ref4" /><ref name="ref5" />. They are not only required for stem elongation but indeed participate in most stages of plant development<ref name="ref3" />. GAs mediate between certain environ-mental signals (e.g. light quality and photoperiod) and the inducedphysiological responses <ref name="ref3" />(e.g. stem extension and flowering). GA-deficient mutants are usually much shorter than the wild type, which indicates  the corresponding genes such as '''''sd1''''' ('''''[[Os01g0883800]]''''')<ref name="ref6" /> in rice may have a relationship with [http://en.wikipedia.org/wiki/The_Green_Revolution The Green revolution].
+* [http://en.wikipedia.org/wiki/Gibberellins  Gibberellins (GAs)] are one of the most important endogenous growth regulators in plants<ref name="ref2" /><ref name="ref3" /><ref name="ref4" /><ref name="ref5" />. They are not only required for stem elongation but indeed participate in most stages of plant development<ref name="ref3" />. GAs mediate between certain environmental signals (e.g. light quality and photoperiod) and the inducedphysiological responses <ref name="ref3" />(e.g. stem extension and flowering). GA-deficient mutants are usually much shorter than the wild type, which indicates  the corresponding genes such as '''''sd1''''' ('''''[[Os01g0883800]]''''')<ref name="ref6" /> in rice may have a relationship with [http://en.wikipedia.org/wiki/The_Green_Revolution The Green revolution].
 * The biosynthesis of GA in higher plants can be divided into three stages: (1) biosynthesis of ''ent''-kaurene in proplastids;(2) conversion of ''ent''-kaurene to GA12 via microsomal cytochrome P450 monooxygenases;(3) formation of C20- and C19-GAs in the cytoplasm<ref name="ref4" /><ref name="ref2" />. GA biosynthesis is catalyzed by three classes of enzymes: terpene cyclases catalyze the synthesis of ''ent''-kaurene from geranylgeranyl diphosphate; cytochrome P450 monooxygenases catalyze the steps of the pathway from ''ent''-kaurene to GA12; and soluble dioxygenases catalyze the final steps of the pathway<ref name="ref5" />.

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 * '''Expression pattern of ''BC12'' '''<br>  Quantitative PCR revealed that '''''BC12''''' is universally expressed in all organs examined, with higher expression in panicles and culms<ref name="ref1" /><ref name="ref2" />. The RT-PCR analyses also shows greater expression of '''''BC12''''' in the tissues enriched in dividing cells than in those enriched in non-dividing cells<ref name="ref1" />.<br><br>
 * '''Expression Analysis in Mutant'''<br> Affymetrix whole-genomemicroarray chip analyses by ''Juan Li et al.'' shows that 116 downregulated and 125 upregulated genes in the mutant compared with the wild type (more than four fold expression change; Figure 2). Of note, the genes involved in cell wall expansion were significantly altered in expression in the mutant. <br>Those encoding xylanase inhibitor protein and cellulose synthase (CESA6) were greatly upregulated. By contrast, the gene for lignin forming anionic peroxidase was downregulated. That imply '''''BC12''''' might be involved in the regulation of genes associated with cell wall assembly.Of note, the expression of the rice KO gene KO2, a key enzyme in early GA synthesis, was greatly decreased in mutation compared with the wild type<ref name="ref2" />.
 [[File:BC12_5.jpg|right|thumb|320px|'''Figure 3.''' ''Phylogenetic tree of '''BC12''' and representative homologs from Arabidopsis and animals.(from reference) <ref name="ref1" />.'']]

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 ===Knowledge Extension===
-* [http://en.wikipedia.org/wiki/Gibberellins  Gibberellins (GAs)] are one of the most important endogenous growth regulators in plants<ref name="ref2" /><ref name="ref3" /><ref name="ref4" /><ref name="ref5" />. They are not only required for stem elongation but indeed participate in most stages of plant development<ref name="ref3" />. GAs mediate between certain environ-mental signals (e.g. light quality and photoperiod) and the inducedphysiological responses <ref name="ref3" />(e.g. stem extension and flowering). GA-deficient mutants are usually much shorter than the wild type, which indicates  the corresponding genes such as '''''sd1'''''[http://ricewiki.big.ac.cn/index.php/Os01g0883800 ('''''Os01g0883800''''')]<ref name="ref6" /> in rice may have a relationship with [http://en.wikipedia.org/wiki/The_Green_Revolution The Green revolution].
+* [http://en.wikipedia.org/wiki/Gibberellins  Gibberellins (GAs)] are one of the most important endogenous growth regulators in plants<ref name="ref2" /><ref name="ref3" /><ref name="ref4" /><ref name="ref5" />. They are not only required for stem elongation but indeed participate in most stages of plant development<ref name="ref3" />. GAs mediate between certain environ-mental signals (e.g. light quality and photoperiod) and the inducedphysiological responses <ref name="ref3" />(e.g. stem extension and flowering). GA-deficient mutants are usually much shorter than the wild type, which indicates  the corresponding genes such as '''''sd1''''' ('''''[[Os01g0883800]]''''')<ref name="ref6" /> in rice may have a relationship with [http://en.wikipedia.org/wiki/The_Green_Revolution The Green revolution].
 * The biosynthesis of GA in higher plants can be divided into three stages: (1) biosynthesis of ''ent''-kaurene in proplastids;(2) conversion of ''ent''-kaurene to GA12 via microsomal cytochrome P450 monooxygenases;(3) formation of C20- and C19-GAs in the cytoplasm<ref name="ref4" /><ref name="ref2" />. GA biosynthesis is catalyzed by three classes of enzymes: terpene cyclases catalyze the synthesis of ''ent''-kaurene from geranylgeranyl diphosphate; cytochrome P450 monooxygenases catalyze the steps of the pathway from ''ent''-kaurene to GA12; and soluble dioxygenases catalyze the final steps of the pathway<ref name="ref5" />.
 ==Labs working on this gene==
 * Research Center for Molecular and Developmental Biology, Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China

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 * National Center for Plant Gene Research, Beijing 100093, China
 ==References==
 <references>

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-Please input one-sentence summary here.
+The rice ''Os09g0114500'' was reported as ''Brittle Culm 12('''BC12''')'' and ''gibberellin-deficient dwarf1 ('''gdd1''')'' respectively in 2010 and 2011 by Chinese researchers<ref name="ref1" /><ref name="ref2" />.
 ==Annotated Information==
 ===Function===
-Please input function information here.
+'''''BC12''''' plays an important role in cell-cycle progression, cellulose microfibril deposition and wall composition in the monocot plant rice<ref name="ref1" />. This gene encodes a kinesin-like protein with transcription regulation activity, which can mediate cell elongation by regulating the expression of the '''''KO2''''' gene in the GA biosynthesis pathway<ref name="ref2" />. It is also likely to be a good subject for exploring the link between cell growth and cell wall formation in rice<ref name="ref1" />.<br><br>
 ===Expression===
-Please input expression information here.
+* '''Expression pattern of ''BC12'' '''<br>  Quantitative PCR revealed that '''''BC12''''' is universally expressed in all organs examined, with higher expression in panicles and culms<ref name="ref1" /><ref name="ref2" />. The RT-PCR analyses also shows greater expression of '''''BC12''''' in the tissues enriched in dividing cells than in those enriched in non-dividing cells<ref name="ref1" />.<br><br>
 ===Evolution===
-Please input evolution information here.
+Phylogenetic analysis by ''Mu Zhang et al.'' revealed that '''''BC12''''' and motor proteins selected from various kinesin subfamilies are divided into separated clades(Figure 3). Kinesin-4 proteins from several representative species were clustered together but formed different subclades. Among the kinesin-4 proteins, those from rice and Arabidopsis were found to belong to a monophyletic clade with 100% bootstrap support. '''''BC12''''' showed the closest homology to FRA1, which has been reported to be involved in cellulose microfibril deposition<ref name="ref1" />.
-You can also add sub-section(s) at will.
+===Knowledge Extension===
 ==Labs working on this gene==
 Please input related labs here.