Os10g0505700

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Annotated Information

Function

Please input function information here. Lipid transfer proteins (LTPs) are typically present in the majority of prokaryotic and eukaryotic cells [1] such as bacteria, yeasts, plants and animals [2]. Plant nsLTPs are basic (with pI 8–10) disulfide-rich proteins divided into two subfamilies; nsLTP1 (~9 kDa) and nsLTP2 (~7 kDa) [3] and [4]. While both proteins have comparable lipid transfer activity, greater stability of nsLTP2 has been proved [5]. Due to their main biological activity, lipid transportation across bio-membranes in vitro, nsLTPs have received much attention from pharmaceutical viewpoints. Owing to the ability of LTPs in promoting the movement of lipids other than phospholipids, clarification of the underlying mechanisms and specificities would be essential to development of LTP-mediated transport systems and controlled release of low molecular weight drugs. A potential role of LTPs in designing efficient drug delivery systems has been suggested [6] and [7]. Their actual biological roles are diverse, including participating in developmental processes and pathogen resistance [8]. Of the two main isoforms, plant nsLTP1 has been studied more frequently and its structure, function and binding properties are well characterized [9] and [10]. Computational studies on nsLTP1 revealed that the insertion of various lipids into the cavity does not necessarily induce significant structural changes with an exception of a prostaglandin. Proteins from various species also varied in terms of molecular surfaces and electrostatic potentials as well as the ability to bind negatively charged lipids. The lack of specificity of ligand binding is suggested to result from nonspecific character of van der Waals interactions [10]. Rice nsLTP2, builds of 69 amino acids and has smaller size, higher structural stability, different disulfide bond pattern and less than 30% sequence similarity with nsLTP1 [11]. Samuel et. al. have performed molecular docking of stearic acid into both LTP1 and LTP2 cavity, demonstrating marked differences between the two isoforms in accommodation of the fatty acid chain in the protein active site. These authors have also reported that there is a tunnel-like hydrophobic cavity running through the whole molecule of rice LTP2 [11]. Despite established beneficial capacities of nsLTP2 to drug delivery [12] and [13] it has not been identified how the plasticity of the protein cavity may help in fitting of diverse molecular shapes and sizes.

Expression

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Evolution

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Labs working on this gene

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References

Please input cited references here. Mojtaba Tousheha, Mehran Miroliaeia Computational evaluation on the binding affinity of non-specific lipid-transfer protein-2 with fatty acids.Comput Biol Med. 2013 Nov;43(11):1732-8.

Structured Information

Gene Name	Os10g0505700
Description	Similar to Nonspecific lipid-transfer protein 2 (nsLTP2) (7 kDa lipid transfer protein)
Version	NM_001071543.1 GI:115482829 GeneID:4349061
Length	523 bp
Definition	Oryza sativa Japonica Group Os10g0505700, complete gene.
Source	Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza.
Chromosome	Chromosome 10
Location	Chromosome 10:19790378..19790900
Sequence Coding Region	19790543..19790818
Expression	GEO Profiles:Os10g0505700
Genome Context	<gbrowseImage1> name=NC_008403:19790378..19790900 source=RiceChromosome10 preset=GeneLocation </gbrowseImage1>
Gene Structure	<gbrowseImage2> name=NC_008403:19790378..19790900 source=RiceChromosome10 preset=GeneLocation </gbrowseImage2>
Coding Sequence	<cdnaseq>atggcgaagtgggcggcgatcatggcggtgctgctgctggcggcggcgtgggcgccggcgccggcgacggcgcagtgcaacgccgggcagctggcgatctgcgcgggcgcgatcatcggcgggtcgacgccgtcggcgtcgtgctgctccaacctgcgcgcgcagagggggtgcttctgccagtacgcgcgcaacccggcgtacgcctcctacatcaacagcgccaacgcccgcaagaccctcacctcctgcggcatcgccatcccccgctgctag</cdnaseq>
Protein Sequence	<aaseq>MAKWAAIMAVLLLAAAWAPAPATAQCNAGQLAICAGAIIGGSTP SASCCSNLRAQRGCFCQYARNPAYASYINSANARKTLTSCGIAIPRC</aaseq>
Gene Sequence	<dnaseqindica>83..358#agcagccagcagccaactgcatcgatatcgatcgatcactcgaccgaccatctcacaagcaaagcaaaagctcgtggcaacaatggcgaagtgggcggcgatcatggcggtgctgctgctggcggcggcgtgggcgccggcgccggcgacggcgcagtgcaacgccgggcagctggcgatctgcgcgggcgcgatcatcggcgggtcgacgccgtcggcgtcgtgctgctccaacctgcgcgcgcagagggggtgcttctgccagtacgcgcgcaacccggcgtacgcctcctacatcaacagcgccaacgcccgcaagaccctcacctcctgcggcatcgccatcccccgctgctaggcacgctcgatctcccgccgccgcgcgccgccgctcgccggcgccggcgccggccatggtgcgtggcaaatatatatatatatatatatatatatatatatatatatatatatactgtgtgtacgtgcgcttgaataaaggacgtgagttaatttgatcggtgtc</dnaseqindica>
External Link(s)	NCBI Gene:Os10g0505700, RefSeq:Os10g0505700