Difference between revisions of "Os01g0100100"
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==Annotated Information== | ==Annotated Information== | ||
===Function=== | ===Function=== | ||
| − | *Rab GTPase involved in membrane transport. They are important regulators in plasma membrane traffic and multivesicular membrane transport. | + | *Rab GTPase involved in membrane transport. They are important regulators in plasma membrane traffic and multivesicular membrane transport.The performance of its function is combined with the cycle between GTP and GDP conformations. In their activated, GTP-bound state, RAB GTPases localize at membranes, where they recruit effector molecules and promote downstream reactions including tethering of transport vesicles or organelles to target membranes required for docking and fusion. Hydrolysis of GTP causes the release of RAB GTPases into the cytosol in a RAB GDP dissociation inhibitor-dependent manner.Activation and inactivation of GTPases are regulated by guanine nucleotide exchange factors and by GTPase activating proteins; these regulators drive the GTPase cycle of RAB proteins. |
| − | *In addition to the plasm membrane, Rab GTPase also participates in the transport of the proglutelin from the Golgi to the protein storage vacuole (PSV). Also, it functions in keeping the general structural organization of the endomembrane system in developing rice seeds. | + | *In addition to the plasm membrane, Rab GTPase also participates in the transport of the proglutelin from the Golgi to the protein storage vacuole (PSV). Also, it functions in keeping the general structural organization of the endomembrane system in developing rice seeds. |
===Expression=== | ===Expression=== | ||
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===Evolution=== | ===Evolution=== | ||
| − | *The average G+C content in rice is higher than in ''Arabidopsis'', but there are no any CpG islands in chromosome 1, indicating a neutral nucleotide distribution in this region. Also, there are a lot of tandem repeats. Some predicted genes were functionally characterized by homology to known proteins using BLASTP. All most all of these genes are also found in ''Arabidopsis''. | + | *The average G+C content in rice is higher than in ''Arabidopsis'', but there are no any CpG islands in chromosome 1, indicating a neutral nucleotide distribution in this region. Also, there are a lot of tandem repeats. Some predicted genes were functionally characterized by homology to known proteins using BLASTP. All most all of these genes are also found in ''Arabidopsis''. |
| − | *This gene encodes Putative GTPase-activating protein, and molecular function is Rab GTPase activator activity, which is homologous with ''Arabidopsis thaliana''. Also, it is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, rice, and frog, and this gene is the one of this super-gene family. | + | *This gene encodes Putative GTPase-activating protein, and molecular function is Rab GTPase activator activity, which is homologous with ''Arabidopsis thaliana''. Also, it is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, rice, and frog, and this gene is the one of this super-gene family. |
==Labs working on this gene== | ==Labs working on this gene== | ||
Revision as of 02:34, 30 May 2014
Please input one-sentence summary here.
Contents
Annotated Information
Function
- Rab GTPase involved in membrane transport. They are important regulators in plasma membrane traffic and multivesicular membrane transport.The performance of its function is combined with the cycle between GTP and GDP conformations. In their activated, GTP-bound state, RAB GTPases localize at membranes, where they recruit effector molecules and promote downstream reactions including tethering of transport vesicles or organelles to target membranes required for docking and fusion. Hydrolysis of GTP causes the release of RAB GTPases into the cytosol in a RAB GDP dissociation inhibitor-dependent manner.Activation and inactivation of GTPases are regulated by guanine nucleotide exchange factors and by GTPase activating proteins; these regulators drive the GTPase cycle of RAB proteins.
- In addition to the plasm membrane, Rab GTPase also participates in the transport of the proglutelin from the Golgi to the protein storage vacuole (PSV). Also, it functions in keeping the general structural organization of the endomembrane system in developing rice seeds.
Expression
This gene is expressed in leaf epidermal cells, root, vascular tissues and stomata, with a molecular mass of 20–25 kDa.<reference /4>
Evolution
- The average G+C content in rice is higher than in Arabidopsis, but there are no any CpG islands in chromosome 1, indicating a neutral nucleotide distribution in this region. Also, there are a lot of tandem repeats. Some predicted genes were functionally characterized by homology to known proteins using BLASTP. All most all of these genes are also found in Arabidopsis.
- This gene encodes Putative GTPase-activating protein, and molecular function is Rab GTPase activator activity, which is homologous with Arabidopsis thaliana. Also, it is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, rice, and frog, and this gene is the one of this super-gene family.
Labs working on this gene
Please input related labs here.
References
<references>Takuji Sasaki, Takashi Matsumoto, Kimiko Yamamoto, et al. The genome sequence and structure of rice chromosome 1[J]Nature, 2002, 420:312-316.
Structured Information
| Gene Name |
Os01g0100100 |
|---|---|
| Description |
RabGAP/TBC domain containing protein |
| Version |
NM_001048268.2 GI:297595880 GeneID:4326813 |
| Length |
7585 bp |
| Definition |
Oryza sativa Japonica Group Os01g0100100, complete gene. |
| Source |
Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
clade; Ehrhartoideae; Oryzeae; Oryza.
|
| Chromosome | |
| Location |
Chromosome 1:2167..9751 |
| Sequence Coding Region |
2449..2616,3357..3455,4457..4560,6136..6997 |
| Expression | |
| Genome Context |
<gbrowseImage1> name=NC_008394:2167..9751 source=RiceChromosome01 preset=GeneLocation </gbrowseImage1> |
| Gene Structure |
<gbrowseImage2> name=NC_008394:2167..9751 source=RiceChromosome01 preset=GeneLocation </gbrowseImage2> |
| Coding Sequence |
<cdnaseq>atgtcgtcggccgcgggccaagacaacggagataccgctggggactacatcaagtggatgtgcggcgccggtggccgtgcgggcggcgccatggccaacctccagcgcggcgttggctccctcgtccgtgacattggcgacccctgcctcaacccatcccccgttaaggggagcaaaatgctcaaaccggaaaaatggcacacatgttttgataatgatggaaaggtcataggtttccgtaaagccctaaaattcattgtcttagggggtgtggatcccactattcgagctgaagtttgggaatttcttcttggctgctatgccttgagtagtacctcagagtataggaggaaactaagagctgttagaagggaaaaatatcaaattttagttagacagtgccagagcatgcacccaagcattggtacaggtgagcttgcttacgctgttggatcaaagctaatggatgtcaggactatgtcaaaagaaacccacattgcagaagaagttagcacaagtcaacaaacttcacaaaatacagctggcagtttagtagaagattcagattatggccccggtggtgcacagcagtcacaaaaaagggaaagctgtagtaaatcagctgaactagttggtttcaacgtacataatgatacctctctttatgattcttccaattttattgtgtcttctacagaagtgaataattgctcaaaagattctcaggattacaatgacatgggtgaaccaagatatgacactgagaccttcgatgattatccttctctacctgttacaaattttttctcaactgatggtgtgggcagcaatggagttgataaaaatcattgtagtttctcagttcctgaagatagattaaggcaccgtgatgaacgtatgcacagcttccaaatcaataataacatagatctcattatagagtcaaattcatgctccagtgatgtgtttagggctagcaacagtgattcagccatctttcactcagatgcatacaagcaggatagatggttagatgataatggctataacagggaagttatagattccttgaggatatctgatgcaccagaagcagattttgttgatggaaccaaatccaacagtgtggttgccagcaaagatcgagtctctgaatggctttggacactgcaccgaattggtatgctctattttttcttcacttcatcatgcaattacagtggtatcttgtga</cdnaseq> |
| Protein Sequence |
<aaseq>MSSAAGQDNGDTAGDYIKWMCGAGGRAGGAMANLQRGVGSLVRD IGDPCLNPSPVKGSKMLKPEKWHTCFDNDGKVIGFRKALKFIVLGGVDPTIRAEVWEF LLGCYALSSTSEYRRKLRAVRREKYQILVRQCQSMHPSIGTGELAYAVGSKLMDVRTM SKETHIAEEVSTSQQTSQNTAGSLVEDSDYGPGGAQQSQKRESCSKSAELVGFNVHND TSLYDSSNFIVSSTEVNNCSKDSQDYNDMGEPRYDTETFDDYPSLPVTNFFSTDGVGS NGVDKNHCSFSVPEDRLRHRDERMHSFQINNNIDLIIESNSCSSDVFRASNSDSAIFH SDAYKQDRWLDDNGYNREVIDSLRISDAPEADFVDGTKSNSVVASKDRVSEWLWTLHR IGMLYFFFTSSCNYSGIL</aaseq> |
| Gene Sequence |
<dnaseqindica>283..450#1191..1289#2291..2394#3970..4831#caaggagtcctcgctgaggaagctttggatccacgacgcagctatggcctccccgcccaccaggccgccagccacaaccagctgactaggtaggcttcctaggtagggatcccatcccttcgattccctactccctcccccgattgatttgatttgatttgatttaattcgattgcctgcttttcaggtcgcatgcatcatcagatttcaatctcccttcgttccctgtccctaatccaataccaatagggagcaatcagctgctcctcgacggcgagggagatgtcgtcggccgcgggccaagacaacggagataccgctggggactacatcaagtggatgtgcggcgccggtggccgtgcgggcggcgccatggccaacctccagcgcggcgttggctccctcgtccgtgacattggcgacccctgcctcaacccatcccccgttaaggttcgcctactcctactctagctccatatggatatggattcgattagctgtctacattctatgccatcaatttgttttccatcacttctcattatacatctccattgctctctaaattaaggcttctctagctctatcctatatatatactagtactccgtatatgattctgcttcatcacttatttattcatcatcataccgtgaagctgtataagtcctgttatttgtcatttggcatatgttgtatagataacactttcagcccagggactttctattgccacttttatacatatacaatcaacatttagcatatgtatatcctgtaccgctcagttgtactgctgctttgaagataatgtttgcaaaacatatgagctcacacacgaggctagatgctgcataggctgcacaatggggtagccattttgatacttcttaatgctatttatgctggtccaaatgttcattggtagcctcaggcagagaattttagggagatattatgtcaaactccctggattcactatgattatacaatattacccattcaatccattcaaataaatttccaggtcaactcacatattgtactgaaagaagactaatttgcactaatcatatccttttatccaccagagtatatgagattgtcttctatatgcaatttacttcatatcgacatttttctgcagaattgcaaaactgacgccttgttttccatctggaattgtgcaggggagcaaaatgctcaaaccggaaaaatggcacacatgttttgataatgatggaaaggtcataggtttccgtaaagccctaaaattcattgtcttaggggtgagttaattgtttcttttgtgcttcaaaaacttgttttttcatgtattttagctgttgaagggtgtggatttttttttcagtcttaatacattaccttttagagcatgatgccccacgcgccatttgtgaatgtgtaaaatagggaagatcaaatagaacgtgacaactgtttattttattaccatgatcattgttctctttgagagtgtctgctttggaaatttcaaagaaattaatgcatatgattgcgtagctctagtttttcttaaaaaaataagcggctaggctctttatactattatgtcacagagtgtttgccttttacctgtgtatgtagctaggcataaacatttgtttgtgggtaaatacaaaaaaaaatccaatgtgtagaaactgcttataaatacataaaagttacataaatacataactgcttcaaataagcaagatttgaacataccttcacataagctttcccctaactgaaaagccatttggtataaccttatagaaattagatatagtggagatgtggaatgagctgctatcaagtcttgtttcgtgaaagcaaactgacacggtctccacagcaaacacgtccacagctttgcaattagtatctttataggaaggtcaatcagagttcattggccatatcttggaaaaaaaaggcatcagattttagtttaattatgtctatattttaggcatggattattgatcatttttgcagcagactaagtttaatgcatgtagttattttccttgattagtgattagtgttgttattttctatacaccactggcactgatagatgtgctccatgctttgcaatgcatcaaaattatcatatcgtgcctaactcatgctttgcacagatatcatttttttgtgttctggcactatctaaagaattgtctataaactaggaacaataagatcgcatcgtactattcttcacattaaaacatttcttacccccaaaattgatgtgcagggtgtggatcccactattcgagctgaagtttgggaatttcttcttggctgctatgccttgagtagtacctcagagtataggaggaaactaagagctgttagaaggtttgacactttcctgttttcagtaccaggataccttttttgtacaagcataagaccgtaagagcataaatgaattgcatttattatctagaataaaatcatgaatgttacagttatgtagtactccctccattccaatatataaggatttcaaggattcaaattttgtaccacaatataaggatttctgcactgattcccataatacccatcatttcagtgattcccaaaccaatcaaatgcatagaaagggaaaagaatcttttgacctaaccttggtattggctaaacaacctagaaatctttatattttggaaaggagggagtaggtattaatttgtttgttttttgtttattgtactaaaactgaacttctaggtaaatattcctatcctttacattttccttgtgttatttataaccatgtgtgcagaatggaaaatgatattaaaagtttaaaacaaatgtgttgctatgtttatctggagtaccaatctcaatctttttcaggcactcaaagtaacttgattagggtttagggtttaccccttttcattgtgctacctcctatacacattgttggggggatgaattggtggcatcagtactcatagtttgtctatgtaacatctacttgtgctgatgttgtatgatccatttggtttagatggcttgataagtaccccgtgcctgcacacaacaatatgacagattatatcaatacatctagggtagaggtaaatgaaagactgagattctagatattgcatacaattcctaggtatttgtggtcatggcctgtgggtgatatcgggttggatatgatccaccaaacctggagcagaaaatttctaagactagttgccagaatagaattctcttggaaatttaacagttccaaacagcctgttcacaaacccattatccattcactagcaggtgctggacagaaaatatgttgttcataggggtttgaacctgggacattaaattctgtagtacgtggtagccaacagtgccaatggctctttctttgtaatggaaggatgcgtattaaagaaattaagtagatgggttggcattgcacactaattagtaatgcaaatataccttagtttattgtgatctctgtaattataattgcatatttatattcctttttatgtctaactatcgaagcgtacctgtgctattacagataaacttattacgtcatatgttcatgttgaattgattggcgtgcgattagtcctttctgtttgcatctgcttgttttattcacttgtgaccaacaaatttataaccaacatcatgtatgccatccataccaattgttgtgcgagaaattctacgttttgcctttgttaccgattctactaattgttgctgatgaatgcgaattccgtgaaatgccatcgcacaagtgtttttattcctttgtttccatttctacggagcagggcaatcagtacagttctgaaattcttgctgagtgttctttcttttgaaagtttttacacctgtgggacaattatggaagcctgtaacctcgtttatttcttcgcttctatgcagggaaaaatatcaaattttagttagacagtgccagagcatgcacccaagcattggtacaggtgagcttgcttacgctgttggatcaaagctaatggatgtcaggactatgtcaaaagaaacccacattgcagaagaagttagcacaagtcaacaaacttcacaaaatacagctggcagtttagtagaagattcagattatggccccggtggtgcacagcagtcacaaaaaagggaaagctgtagtaaatcagctgaactagttggtttcaacgtacataatgatacctctctttatgattcttccaattttattgtgtcttctacagaagtgaataattgctcaaaagattctcaggattacaatgacatgggtgaaccaagatatgacactgagaccttcgatgattatccttctctacctgttacaaattttttctcaactgatggtgtgggcagcaatggagttgataaaaatcattgtagtttctcagttcctgaagatagattaaggcaccgtgatgaacgtatgcacagcttccaaatcaataataacatagatctcattatagagtcaaattcatgctccagtgatgtgtttagggctagcaacagtgattcagccatctttcactcagatgcatacaagcaggatagatggttagatgataatggctataacagggaagttatagattccttgaggatatctgatgcaccagaagcagattttgttgatggaaccaaatccaacagtgtggttgccagcaaagatcgagtctctgaatggctttggacactgcaccgaattggtatgctctattttttcttcacttcatcatgcaattacagtggtatcttgtgattatgttctaatttgcaaaacctattacagtggttgatgtggttagaacggatagtcatcttgatttctatggagaatcaagaaatatggctaggatgtcagatatacttgcagtttatgcatgggttgatccttccaccgggtattgccaaggtatatgcatatttcagtggcatctttttttacttcctttttggtttcttgatgtgtctaaatgggataagttgctaacaggtatgagtgatctactttcaccttttgttgttctctatgaggatgatgcagatgccttttggtgctttgagatgctactgagaaggatggtaattcacatatatttcaaattttgttgcctattagtttggtttctatgttactccatgcataatatgtgccctgttccacttcagcgtgaaaatttccagatggagggaccaacaggagttatgaagcagttgcaagcattgtggaagatcatggaaataactgatgtagaattatttgaacatttgtcaacaattggtgctgaaagccttcattttgctttccggatgctgctagtgctttttcgtcgagagctgtcctttgaggagtcacttagcatgtgggaggtgtggcatttgaagacacatgtattatcttttttcagttgttgttcttcgtaggaaagctctaatggatgtttgtttgtcagctggtgtaggtctaggggatgttggttaagccttttttatttcaaaaattgtattactagttaaatatttcaaatagtaaaatagggtacatcttcgatttaggttcaaaatcatcagaggtgtaggtagatggttcattacgattgtagttaatgtttgtgatatcatgtggcatgtgaactttatactccctcgggtcacaaatatttgacgtttaggacaagatgtggtcaaacttttaaaattttgaccgtcaataacagctcaaatgcgtagcttataaaaacacaaaaaaagatatgcggagatttgccttgcaaggtattagtgtcataatatgatacacttattagattttatagtcttattctgatataaaattgatggtcagtttcaaaagttttgaccaaatcttgttctaaacatcaaatatttatgatcggagggaacattacttataaaatgctcttcacactgcagtcttgatctgttaaccaaccgtgcttcttgctttcagatgatgtgggctgctgactttaatgaagatgtgattttacatttggaagagaattgtctggagccattgctggtagatatgaggaatgatttatcatgtgaggtgaaagaagagcaccgggtgaacagttacacaagaagaaagtccaaaagcaggaagccccatcatagaaatggtgaaatgcgtgtagcttgcaaccttggaatgaaacccaatacaagaaatcccctctgtggcttgtcaggagctactatttgggcaagacatcagcagatgccacatataagcacaaatgtgttagcaaagaatggagatgatgatctgcctatattctgcgtagcagcaatccttgtaatcaatcgccacaagataattagagaaactcgctcaatagatgatgcaatcaaggcaagtttaagtcacaacttcctttcatattgtttacaaacctcggatccatgaaattactaccaagagttacctatatttgcattagattttgtggaattcattttaggcaaaattaaaaatttgctcagacagtacaataacatgttatggccgatcatttctgcataaatgactattgattttgtcctctgctgaattgatgggtttaattagaggatgcttatttcattctgataactatcaatatttacaagttacggcaactgctaattaaaaatgatgcccagcctttctccctcttggaaaaaaagatgggtaaacctgtatatagtggtgatattgactctgctgagcagtcttccacttaaatgggaagagttaaggaaagtatagtcaggtttacttataatgcaacttattggcatattaatgcatgtttattgtttgcactcctgaagttgagttggtcaattttttccatagatgttcaatgataatatgctgaagatcaatgtaaaaagatgcgtacgcatggctatcaagctgaggaagaagtatatttacaaggtaaattgtgataagcatacatgagcaccatccatgtttttcaggtatatttacaaggtaagttctaatttggtcttgggatacagttattgaaggggggctcggaatgatgaaaaagtggaaactgaagttgagaaatcgccctggggaactagatgtttttcaaccatgaacttctcgtaattatgggtgatggaactttatatattcattagaagtccaaaaaaaatccgtatactcacggtatggattccctctttctgtttatgttttgttagagatggatgacgtacataatctgcttgtcttgtttcagggaatctgtacatatgcacagtatacttgaaaacaagagacgaagcggtggaaggataatagagaagaccgccatgttggtgtagcatcgatcgatgttgtcattgtttttgtggtgccagcccatctgccttggcactttccgtggtgatttctgataaaagtggagtactagttgttttttctttttgccaaacaatttgcgtcagctattggtggagagagaaggaatgaatgaggaatgtgtat</dnaseqindica> 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