CL971152

Function

CL971152, GW5, on rice chromosome 5, controls rice grain width and weight, encodes a novel nuclear protein of 144 amino acids that is localized to the nucleus. GW5 represents a major QTL underlying rice width and weight, and that it likely acts in the ubiquitin-proteasome pathway to regulate cell division during seed development[1].GW5 is associated with rice domestication. The GW5 gene was mapped to an interval between markers RM3328 and RMw513 in 805 homozygotes, the GW5 gene was mapped to a genomic region 2.7 cM in length, located 2.3 cM from RM3328 and 0.37 cM from RMw513. GW5 is associated with a 1 212-bp deletion in the Asominori. GW5 protein may play an important role in regulating the grain shape through involvement with the ubiquitin-proteasome pathway cultivar.GW5 occurred in the wide-grain lines, including most japonica and a few indica rice, whereas GW5 was present in the slender-grain rice, including most indica and a few japonica rice cultivars. GW2 and GW5 in controlling seed development. GW5 may work together with GW2 in targeted degradation of certain substrates that promote cell division and grain growth. GW5 may also work together with the deubiquitinating enzymes and might be involved in reversing ubiquitination by substratespecific cleavage of ubiquitin moieties[1].

Reference

1.Jianfeng Weng; Suhai Gu; Xiangyuan Wan; He Gao1; Tao Guo; Ning Su; Cailin Lei; Xin Zhang; Zhijun Cheng; Xiuping Guo; Jiulin Wang; Ling Jiang; Huqu Zhai; Jianmin Wan. 2008. Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight. Cell Research, 18(12): 1199-1209.