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| − | {{JaponicaGene|
| + | The rice '''''Os02g0720700''''' was reported as '''''OsCBSCLC9a''''' in 2009 <ref name="ref1" /> by researchers from India. |
| − | GeneName = Os02g0720700|
| + | ==Annotated Information== |
| − | Description = Similar to Chloride channel protein CLC-f (AtCLC-f). Splice isoform 2|
| + | ===Gene Symbol=== |
| − | Version = NM_001054490.1 GI:115448350 GeneID:4330553|
| + | *'''''Os02g0720700''''' '''''<=>''''' '''''OsCBSCLC9a''''' |
| − | Length = 4784 bp|
| + | ===Function=== |
| − | Definition = Oryza sativa Japonica Group Os02g0720700, complete gene.|
| + | * CBS domains are found to be associated with several proteins of unrelated functions, such as inosine-5'-mono- phosphate dehydrogenase (IMPDH), AMP-activated protein kinase (AMPK), chloride channels (CLC) and cys-tathionine-β-synthase (CBS). |
| − | Source = Oryza sativa Japonica Group
| + | * Mutation in CBS domains abolish or strongly reduce activation by SAM and cause homocystinuria. |
| | + | * CBS domain of γ-subunit of AMPK acts as sensor of cellular energy status and mutations cause a glycogen storage disease, which is clinically expressed as a familial hypertrophic cardiomyopathy. |
| | + | ===Evolution=== |
| | + | * CBS domain exists not only in archaebacterial proteins, but also in eubacterial and eukaryotic proteins |
| | + | * In CBS protein, C-terminal CBS domain exerts an autoin-hibitory effect on the CBS activity, while binding of SAM (S-adenosylmethionine) with CBS domain induces a conformational change which relieves the autoinhibitory effect. |
| | + | You can also add sub-section(s) at will. |
| | + | ==Labs working on this gene== |
| | + | * Centre for Computational Biology and Bioinformatics, School of Information Technology, Jawaharlal Nehru University, New Delhi 110067, India |
| | + | * Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India |
| | + | * Stress Physiology and Molecular Biology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India |
| | + | ==References== |
| | + | <references> |
| | + | * <ref name="ref1"> |
| | + | Kushwaha HR, Singh AK, Sopory SK, Singla-Pareek SL, Pareek A. Genome wide |
| | + | expression analysis of CBS domain containing proteins in Arabidopsis thaliana |
| | + | (L.) Heynh and Oryza sativa L. reveals their developmental and stress regulation. |
| | + | BMC Genomics. 2009 Apr 28;10:200. doi: 10.1186/1471-2164-10-200. PubMed PMID: |
| | + | 19400948; PubMed Central PMCID: PMC2694836. |
| | + | </ref> |
| | + | </references> |
| | | | |
| − | ORGANISM Oryza sativa Japonica Group
| + | ==Structured Information== |
| − | Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
| + | [[Category:Genes]][[Category:Oryza Sativa Japonica Group]][[Category:Japonica Chromosome 2]] |
| − | Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
| |
| − | clade; Ehrhartoideae; Oryzeae; Oryza.
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| − | |
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| − | Chromosome = [[:category:Japonica Chromosome 2|Chromosome 2]]|
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| − | AP = Chromosome 2:30786158..30790941|
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| − | CDS = 30786657..30786729,30786873..30787105,30787359..30787574,30787700..30787927,30788088..30788192<br>,30788293..30788747,30789114..30789308,30789605..30790007,30790443..30790886<br>|
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| − | GCID = <gbrowseImage1>
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| − | name=NC_008395:30786158..30790941
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| − | source=RiceChromosome02
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| − | preset=GeneLocation
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| − | </gbrowseImage1>|
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| − | GSID = <gbrowseImage2>
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| − | name=NC_008395:30786158..30790941
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| − | source=RiceChromosome02
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| − | preset=GeneLocation
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| − | </gbrowseImage2>|
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| − | CDNA = <cdnaseq>atgtcgtcccgcggcggcgaggacgacgaccacgcctcgctcctcagatcccaccccgcggccggcgccggcgccgggtccggctcatcgtcgccgtgcccatctccgcgggctgtcggtggccaccaccacaaccagcacgcggacgtcgaggcggtgggggaggccaccgtcaccgcctccccgaggcggagcggcggcgtgcgtggcctcctgcggcacctcgaccgccgcctctccgcgcgcggatccggggggcgtcgaagccagcagccgccgcagcagctcgatcgccccgagccgtccccgacgtcgtcgccgcagcagagggagagggtcggggaggagctcggggatggggcgccgccggagtgggcgctgctgctcatcggctgcctcctcgggctcgccaccggcatttgcgtcgccgcgtttaaccgtggggttcatgtcatccatgaatgggcttgggcaggtaccccaaatgaaggtgcagcttggctccgccttcagaggctagctgatacttggcacagaatactgctgatccctgtgacaggaggcgttgttgtaggaatgatgcatgggttgcttgagatatttgatcagctcaaactcgtgaaaccgcctcagaaacaaggaatcaatttccttgcggcaatctttccaactgtaaatgctgtccaggctgctgtaactctaggtactggttgctcactggggcctgaaggtcctagtgtggatattggcaaatcatgtgcaaatgggtgctcggaaatgatggagaataacagggagaggcggattgctcttgtagctgctggtgctgctgctggaattgcttcaggcttcaatgcagcagttgctgggtgtttctttgccattgaaactgtactgaggccactgaaagcagaaaattcacctccttttacaactgcaatgataatattggcttctgttatatcatctactgtgtcaaatgttctgcttggagaaaggccagcttttatagtgccagcgtatgagctaaaatctgctgccgagctacctttatatctcatcttaggaatgctttgtggagcggtcagtgtggtatttggccggttggttgtatggttttcgaatttttttggatacttaaaagaaagatacgattttcctattgtagtataccctgctttgggtggactgggagctggcctcatagctctcaaatatcctggcattctatactggggtttcacaaatgttgaagaaatactacatactgggaaaagtgcttctgctcctggtatatggttgttaactcagcttgcagctgcaaaggtagttgcaactgccctttgcaagggatctggccttgtgggtgggctatatgcaccaagcctaatgattggggctgctgttggagctgtttttggagggtcagctggatatttgataaattctgctgtacctggtaatgctgctgttgcacagccacaagcttatgctctagttggaatggctgctacactagcttcagtctgttcagtcccactgacctcagtgctgcttctctttgaactgacaaaggactacaggattttgcttcctctcatgggagcagttgggttagcaatctgggttccttctgtagtaaaccaatcaaaggatggtgaaccatctaggtttagaacacccaggcgtggttattcttcactttcttcagaagatagaaatagtaaaagctggaggcgaggtgacagtgtaaatgatcttgagctcactagcttacggactgataactatgacacctataatgaggaaatgcttctagatgatttgaaggtctcccaggccatgtcaaagagctatgttaaaattccaacatctgccatggtgacagaagctctcaagcttttgcatgataagcagcaaaattgcggccttgttgtggattgtgaagattttctcgaaggaattgttacattaggggatattcgccgtatgggatttgaattacatggggacagtttcacaagtggagaccagctcaagcccgctgaaaattcttcaaccatatcattgtgtcttactcgaggattccagtacgaggggaatgaacgtggattgctaacctgctttcctgatactgatttgaccactgcaaaaaaccttatggaggccagaggaataaagcagctgcctgtcgtgaagcgtggtgtcggccatagaactgaaggaaaacgcaagcttattgctcttctacattatgattctattggtcactgcttacgggaggaaattgagaactggaaggccatatatcaaataaaagaggacttccatctcatagcaaatgggcattga</cdnaseq>|
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| − | AA = <aaseq>MSSRGGEDDDHASLLRSHPAAGAGAGSGSSSPCPSPRAVGGHHH NQHADVEAVGEATVTASPRRSGGVRGLLRHLDRRLSARGSGGRRSQQPPQQLDRPEPS PTSSPQQRERVGEELGDGAPPEWALLLIGCLLGLATGICVAAFNRGVHVIHEWAWAGT PNEGAAWLRLQRLADTWHRILLIPVTGGVVVGMMHGLLEIFDQLKLVKPPQKQGINFL AAIFPTVNAVQAAVTLGTGCSLGPEGPSVDIGKSCANGCSEMMENNRERRIALVAAGA AAGIASGFNAAVAGCFFAIETVLRPLKAENSPPFTTAMIILASVISSTVSNVLLGERP AFIVPAYELKSAAELPLYLILGMLCGAVSVVFGRLVVWFSNFFGYLKERYDFPIVVYP ALGGLGAGLIALKYPGILYWGFTNVEEILHTGKSASAPGIWLLTQLAAAKVVATALCK GSGLVGGLYAPSLMIGAAVGAVFGGSAGYLINSAVPGNAAVAQPQAYALVGMAATLAS VCSVPLTSVLLLFELTKDYRILLPLMGAVGLAIWVPSVVNQSKDGEPSRFRTPRRGYS SLSSEDRNSKSWRRGDSVNDLELTSLRTDNYDTYNEEMLLDDLKVSQAMSKSYVKIPT SAMVTEALKLLHDKQQNCGLVVDCEDFLEGIVTLGDIRRMGFELHGDSFTSGDQLKPA ENSSTISLCLTRGFQYEGNERGLLTCFPDTDLTTAKNLMEARGIKQLPVVKRGVGHRT EGKRKLIALLHYDSIGHCLREEIENWKAIYQIKEDFHLIANGH</aaseq>|
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| − | DNA = <dnaseqindica>4213..4285#3837..4069#3368..3583#3015..3242#2750..2854#2195..2649#1634..1828#935..1337#56..499#gccgcattcctccgcgcccctcagatctccgctgactccgccgccgcccgccgacatgtcgtcccgcggcggcgaggacgacgaccacgcctcgctcctcagatcccaccccgcggccggcgccggcgccgggtccggctcatcgtcgccgtgcccatctccgcgggctgtcggtggccaccaccacaaccagcacgcggacgtcgaggcggtgggggaggccaccgtcaccgcctccccgaggcggagcggcggcgtgcgtggcctcctgcggcacctcgaccgccgcctctccgcgcgcggatccggggggcgtcgaagccagcagccgccgcagcagctcgatcgccccgagccgtccccgacgtcgtcgccgcagcagagggagagggtcggggaggagctcggggatggggcgccgccggagtgggcgctgctgctcatcggctgcctcctcgggctcgccaccggcatttgcgtcgccgcgtttaaccgtggggtgagcatttcactggttctgctcacagactggaaacttgactatcctctgcaagtagaaagcaccggagtgaggctcatcatttataggatctaaacgtagttcatggatgctagcaaatgtgaacccaagggactttgcaaatgtgattttgatccgtttatttgtgcaaactaaactagtgcaaataaattcacccaaatgatgcaaaatcagtttcatttaagtgcgcaaattcaaagcaacttaacagagcactgaaagcagtaaatgaaaagccttatgtcacatcatatctgcggttgcccaaaacgcgataaattttgttaaaatttaaaaccttccaagtgattccaatgtaagttaaggttgagatttttcagttctgccttgcatgactgattctatagacagctcctgttatggtatttttaggttcatgtcatccatgaatgggcttgggcaggtaccccaaatgaaggtgcagcttggctccgccttcagaggctagctgatacttggcacagaatactgctgatccctgtgacaggaggcgttgttgtaggaatgatgcatgggttgcttgagatatttgatcagctcaaactcgtgaaaccgcctcagaaacaaggaatcaatttccttgcggcaatctttccaactgtaaatgctgtccaggctgctgtaactctaggtactggttgctcactggggcctgaaggtcctagtgtggatattggcaaatcatgtgcaaatgggtgctcggaaatgatggagaataacagggagaggcggattgctcttgtagctgctggtgctgctgctggaattgcttcaggtatgtcattgatgattacgtacctgtttccttagtagaatatcatgacttcgatagctagcaccttacaattattatttaaggatgtattacgtaatggcaattccatgtaaattggatagcatttatagttaacatgtattgtttcggatatctttgtaaaataacttgaaatattgtatttcacgactcccatgtaactctaaaatttaacattttgattttgttcctacccttttggcctttttgttgttagcgcttgctaatatactgtttcttgtgttgtgtgttttcaggcttcaatgcagcagttgctgggtgtttctttgccattgaaactgtactgaggccactgaaagcagaaaattcacctccttttacaactgcaatgataatattggcttctgttatatcatctactgtgtcaaatgttctgcttggagaaaggccagcttttatagtgccagcgtatgagctaaaatctgctgccggtatctcccctgattctttttacctttatctttaagattgaagattcatctattaactacagtaacaaacactaccaatttttatcatgttatgatacaccacttgcaccactaccaattcttggttcatcaagccctaatatgctatctccattttgttgaggcctatagtaatatgtttcagagatgatgttatcataaagtttagcagcacttgccctacttttataagttattcacacaaacccaacttttctattatcttgacatggcttcttggttgaataattctctccttttgtattgttgtatatgaacagcataggttctaaaggatattctgtcgtctcattttctgttctgcagagctacctttatatctcatcttaggaatgctttgtggagcggtcagtgtggtatttggccggttggttgtatggttttcgaatttttttggatacttaaaagaaagatacgattttcctattgtagtataccctgctttgggtggactgggagctggcctcatagctctcaaatatcctggcattctatactggggtttcacaaatgttgaagaaatactacatactgggaaaagtgcttctgctcctggtatatggttgttaactcagcttgcagctgcaaaggtagttgcaactgccctttgcaagggatctggccttgtgggtgggctatatgcaccaagcctaatgattggggctgctgttggagctgtttttggagggtcagctggatatttgataaattctgctgtacctggtaatgctgctgttgcacagccacaagcttatgctctagtaagttgctctgttttcctttttttttttcatattgcttgaagcaatactgttatttctacatccttgtatatacaaaaactaattgtcagaactccaggttggaatggctgctacactagcttcagtctgttcagtcccactgacctcagtgctgcttctctttgaactgacaaaggactacaggattttgcttcctctcatggtaagtatgactgtttatgtagtgtgcccattgttttgttttgatatagtctttctcttttgtcacatcatgatgtctagaagaggacataaatgttgtgattttatgtttcactattgcattatcaaaactaatgcacttattttttattgtccaacagggagcagttgggttagcaatctgggttccttctgtagtaaaccaatcaaaggatggtgaaccatctaggtttagaacacccaggcgtggttattcttcactttcttcagaagatagaaatagtaaaagctggaggcgaggtgacagtgtaaatgatcttgagctcactagcttacggactgataactatgacacctataatgaggaaatgcttctagatgatttgaaggtttgtaggcctctaattcttattgttaacggtctagctgatgcaatggtgcgttcaattttcaatagaagtacatgttattatgttaattctatcctaatttgtcatttgaactcttttaccaggtctcccaggccatgtcaaagagctatgttaaaattccaacatctgccatggtgacagaagctctcaagcttttgcatgataagcagcaaaattgcggccttgttgtggattgtgaagattttctcgaaggaattgttacattaggggatattcgccgtatgggatttgaattacatggggacagtttcacaagtggagaccagctcaagcccgctgtacgtttgaatggtgaaaatatgtatttccattagaatagttctacgtaaataagtaatgaattggtgtgcatcatttcacttggtctggtctaggctggacactgattttgtttaaaccattgccatttaatgcgatagcttaaaatgaattctaaattgaatgtacatgctttctatctctgaaaggtaaaaacaaaacaatttacacaggctggcaaggaatgtgtactaattaatggagatgttgcaggaaaattcttcaaccatatcattgtgtcttactcgaggattccagtacgaggggaatgaacgtggattgctaacctgctttcctgatactgatttgaccactgcaaaaaaccttatggaggccagaggaataaagcagctgcctgtcgtgaagcgtggtgtcggccatagaactgaaggaaaacgcaagcttattgctcttctacattatgattctattggtcactgcttacggttagtcataagcttatatgtgttctttcaaactttatatttttttgggtttattcagctttaactcaagataattgaattttttttccgcttgtttaattcatttgaattatactgaaatgtcaattcatttggttatgaagggaggaaattgagaactggaaggccatatatcaaataaaagaggacttccatctcatagcaaatgggcattgaacagcattacattgaccaatattacaccacatcaatcgcatgcaatttgatatccttaaggcatttttgccaaatggggatacaggaggtatacacgaagttcaacttgtacagatttgaggctcctctacaaagaattaaattgccatctgaggaaattattcaggctagctagccaattttgcaatagaggttatggtccattcttgttgcgaagcaacttctacttcacacgggaggagatgggtatgtatgaattcagttattcagaattggaaagtggcattgtaatgtatatcttgtacctgtactatttgtaactgtgtaacatcctgttgctgggaagcatcatatgcgccagcttgtagaggtgcagtcacacgagaaactagtgtaataaagtgtgcagcagaaaattttgtcaagaagccgatgttgtaggttgtagcgtcacattgtatgtaacactttatatcagcacttgaactgaatttctccc</dnaseqindica>|
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| − | Link = [http://www.ncbi.nlm.nih.gov/nuccore/NM_001054490.1 RefSeq:Os02g0720700]|
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| − | }}
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| − | [[Category:Genes]] | |
| − | [[Category:Japonica mRNA]]
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| − | [[Category:Oryza Sativa Japonica Group]] | |
| − | [[Category:Japonica Genes]] | |
| − | [[Category:Japonica Chromosome 2]]
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| − | [[Category:Chromosome 2]]
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