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| − | {{JaponicaGene|
| + | The rice '''''Os08g0300300''''' was reported as '''''OsCBSCLC6a''''' in 2009 <ref name="ref1" /> by researchers from India. |
| − | GeneName = Os08g0300300|
| + | ==Annotated Information== |
| − | Description = Similar to C1C-Nt1 protein|
| + | ===Gene Symbol=== |
| − | Version = NM_001068028.1 GI:115475793 GeneID:4345218|
| + | *'''''Os08g0300300''''' '''''<=>''''' '''''OsCBSCLC6a''''' |
| − | Length = 6259 bp|
| + | ===Function=== |
| − | Definition = Oryza sativa Japonica Group Os08g0300300, complete gene.|
| + | * CBS domains are found to be associated with several proteins of unrelated functions, such as inosine-5'-mono- phosphate dehydrogenase (IMPDH), AMP-activated protein kinase (AMPK), chloride channels (CLC) and cys-tathionine-β-synthase (CBS). |
| − | Source = Oryza sativa Japonica Group
| + | * Mutation in CBS domains abolish or strongly reduce activation by SAM and cause homocystinuria. |
| − | | + | * CBS domain of γ-subunit of AMPK acts as sensor of cellular energy status and mutations cause a glycogen storage disease, which is clinically expressed as a familial hypertrophic cardiomyopathy. |
| − | ORGANISM Oryza sativa Japonica Group
| + | ===Evolution=== |
| − | Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
| + | * CBS domain exists not only in archaebacterial proteins, but also in eubacterial and eukaryotic proteins |
| − | Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
| + | * In CBS protein, C-terminal CBS domain exerts an autoin-hibitory effect on the CBS activity, while binding of SAM (S-adenosylmethionine) with CBS domain induces a conformational change which relieves the autoinhibitory effect. |
| − | clade; Ehrhartoideae; Oryzeae; Oryza.
| + | You can also add sub-section(s) at will. |
| − | |
| + | ==Labs working on this gene== |
| − | Chromosome = [[:category:Japonica Chromosome 8|Chromosome 8]]|
| + | * Centre for Computational Biology and Bioinformatics, School of Information Technology, Jawaharlal Nehru University, New Delhi 110067, India |
| − | AP = Chromosome 8:12438731..12444989|
| + | * Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India |
| − | CDS = 12442996..12443121,12443292..12444429,12444550..12444902|
| + | * Stress Physiology and Molecular Biology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India |
| − | GCID = <gbrowseImage1>
| + | ==References== |
| − | name=NC_008401:12438731..12444989
| + | <references> |
| − | source=RiceChromosome08
| + | * <ref name="ref1"> |
| − | preset=GeneLocation
| + | Kushwaha HR, Singh AK, Sopory SK, Singla-Pareek SL, Pareek A. Genome wide |
| − | </gbrowseImage1>| | + | expression analysis of CBS domain containing proteins in Arabidopsis thaliana |
| − | GSID = <gbrowseImage2>
| + | (L.) Heynh and Oryza sativa L. reveals their developmental and stress regulation. |
| − | name=NC_008401:12438731..12444989 | + | BMC Genomics. 2009 Apr 28;10:200. doi: 10.1186/1471-2164-10-200. PubMed PMID: |
| − | source=RiceChromosome08
| + | 19400948; PubMed Central PMCID: PMC2694836. |
| − | preset=GeneLocation
| + | </ref> |
| − | </gbrowseImage2>|
| + | </references> |
| − | CDNA = <cdnaseq>cctcatgacctaccacctcaaggacatccccatcgtcgtcctcatcggcgtgatcggcgccatcttgggcgccctctacaacttcctcatgatgaaggtcctgcgcgtctacagcgtgatcaacgagaggggcaacgcgcacaagctgcttctggcggcggtggtgtccatcctgacgtcgtgctgcgtgttcggcctgccgtggctggcgccgtgccggccgtgcccgacagccggggcgccgtcgccgccgaacgggacgtgccattcgctgaaccgattccggcggttccactgcccggcggggcactacaacgacttggccagcctcttcctcaacatcaacgacgacgccatccgcaacctctactccacgggcaccaacgacgtctaccacccgggctccatgctcgcctttttcgtcgcctcctacgcgctcggcgtgctcagctacggcgtcgtcgcgccgtcggggctgttcgtccccatcatcctcaccggcgccacctacggccgcctcgtcgccatgctgctcggcggccgctcaggactcgaccacggcctcgtcgccatcctcggctccgcctccttcctcggcggcacgctccggatgacggtgtccgtgtgcgtcatcatcctggagctcaccaacaacctgctcctcctcccgctcgtcatgctcgtgctgctcatctccaagaccgtcgccgactccttcaactccagcatctacgacctcatcctcaatctcaagggcctcccgcacctcgacggccacgccgagccgtacatgcggcagctcaccgtcggcgacgtggtggccgggccgctgcggagcttcaacggcgtcgagaaggtgggccacatcgtgcacacgctccggaccacggggcaccacgcgttcccggtggtcgacgagccgcccttctcgccggcaccggtgctgtacggcctcgtgctgcgcgcgcacctgctggtactgctcaagaagcgggagttcctgacggcgccggtgcggtgccccaaggactacatggccgggaggttcgaggcgcaggacttcgacaagcgcgggtccgggaagcaggacaccatcgccgacgtggagctgtcgccggaggagatggagatgtacgtcgacctgcaccccttcaccaacacgtcgccgtacacggtggtggagaccatgtcgctggccaaggcgctcgtcctcttccgcgaggtcggcctgcgacacctcctcgtcgtgcccaagtcctgcgacaggtcgccggtggtggggatcctgacgaggcacgacttcatgccggagcacatcctcgggctgcacccggtgctggtgggaagccggtggaagcggctccggtggcagaagggcgccgtcgccaagaaattccggtcgctcctcgactggctagccaacgacagcggctgatcgatcgatgcagaggagtacattatattgatacacgcacatacattctggccggacaacgagggatgatgatgatggagtgcttgcacataaatatacgtacatacacgttggattggtcattgagtttttgtgaattttgtgcaataataacagcacctatacctggtggtcatgaatga</cdnaseq>|
| + | ==Structured Information== |
| − | AA = <aaseq>PHDLPPQGHPHRRPHRRDRRHLGRPLQLPHDEGPARLQRDQREG QRAQAASGGGGVHPDVVLRVRPAVAGAVPAVPDSRGAVAAERDVPFAEPIPAVPLPGG ALQRLGQPLPQHQRRRHPQPLLHGHQRRLPPGLHARLFRRLLRARRAQLRRRRAVGAV RPHHPHRRHLRPPRRHAARRPLRTRPRPRRHPRLRLLPRRHAPDDGVRVRHHPGAHQQ PAPPPARHARAAHLQDRRRLLQLQHLRPHPQSQGPPAPRRPRRAVHAAAHRRRRGGRA AAELQRRREGGPHRAHAPDHGAPRVPGGRRAALLAGTGAVRPRAARAPAGTAQEAGVP DGAGAVPQGLHGREVRGAGLRQARVREAGHHRRRGAVAGGDGDVRRPAPLHQHVAVHG GGDHVAGQGARPLPRGRPATPPRRAQVLRQVAGGGDPDEARLHAGAHPRAAPGAGGKP VEAAPVAEGRRRQEIPVAPRLASQRQRLIDRCRGVHYIDTRTYILAGQRGMMMMECLH INIRTYTLDWSLSFCEFCAIITAPIPGGHE</aaseq>|
| + | [[Category:Genes]][[Category:Oryza Sativa Japonica Group]][[Category:Japonica Chromosome 8]] |
| − | DNA = <dnaseqindica>4266..4391#4562..5699#5820..6172#gctcccctcgtctccctctgcggcaagctctctcatggcgtgcacggctccacgggaggaggacctcctcatggaggaagacgagcaccggccgcctctcaaccgggccctgctccaccgcagcgccaccaacaacacctcccaggttgccatggtcggctccaacccctgccccatagagagcctcgattacgagtacgcgccccctctcctctgtggctctgcctccctttctctctccgttcgttcttgtcagggactctggatcctaccacctgtatcgtctgatctttcccaatccttgcttctccatcatgttgaattgttgattcaatgtcgagatgaaatgctttttcttatccaatagtgttccatgatttgcttcttgattgggatagcatctcaatgttgctgcctcgtttcgtatggtgatccaattgctctctgtttattgattcagctgtcctctcaaggacatgtcatgttcctgccacctattgtcttgtcagaaatgtttgtatcttgcttgcccccacttgcattttcatccacctactcctgcggaggttatcttactcgctgcaattaccattccaatttgctaatatagtaatatacacagctctgtaacctgttggtaatattttcgtcggtttgcgacaatgctaattcgttttccttttctttggggatttgatttgggttacaggataatagagaacgacctgttcgatcagaactggaggtcgagagggaaagccgaccaggtgcggtacgtggtgctcaagtggaccttctgcttcgccatcggcatcatcaccggcatcgccggcttcgtcatcaacctcgccgtcgagaatgtcgccggcctcaagcacaccgccgtgtccgccctcatggagtccagcaggttctgctcattgcctcctattgccttgtccaagaaaaaagtaatgttgcttttgctgagtacgacaaattcactcatgcttgtctcctgctttgtctattattatcccgtactctttttgtccctgatcagatcaattcttgttcaaatctgagaatgctatctgtcaagtgatctagaattctgaaccctcaaaattgactgaatttttggaacaaagatcaatttctgtctgttactccgagtctgaagtctgaaactcatgtcggatgcagctattggacagcgttctggctgttcgccggaaccaacctggccctgctgctgttcgcgtcgtccatcacggcgttcgtgtcgccggcggccggcgggtcggggatcccggaggtgaaggcctacctcaacggcgtggacgcgccaaacatcttctcgctcaggacactcgctgtcaaggtgcgttcctatcctcctctacagctcagcgcagattagcacatgagccactcccaattactgtaattgccagttgtgcgactgatttttttttctcttctttttttggaactgtgtgcctgaattatccacgggcaaaagggacattaattcgttctatattaggctgtgttcagttcccttcaaacttccaaaaattctgtgtttggacacatgcatagatcattaaacgtggacgaaaaaaaacaattacacagtttgcatacaaattgcgagacgaatcttttgaccctaactacaccatgatttgataatgtggagctacaataaacatttgctaatgacagattaattaggcttaataaattcgtcttgcagtttatagacgaaatatgtaatttatttttgttactaatctacatttaatactttaaatatgtgtccgtatacttaaaaaaaattggccaaagaactaaacacggccttagtggtagtactattaggatcaaaagaatagccgtgatcgtgcaagtttctgccaaaaaattagtgctaattcttttacgatgaaagggcatgttcttgcagcaaagaattgttttatgtgtgtggctgtttgttttacatgggcatcattaataattgagaccttgggtgtcctttttattattgtttggatccactacatacatcactcatccgtttactttacctgtttgctctctattggggttgacagagttataaaatggatccatgattgatatagaatctctagatctttatctcatgaaagtgaaatgtaacagcacgacttccgtttgaattggaatgcctacaaagtcctcaataattgatacttattttgtttttctgtagatttcttaaaaccccaatattcataaaacgagtcaacttgttcatttgagcgactgaaatattcctatctatcaattatttttttagtaaatttcatagaactacagatacatgggttaaattatcgcaaaattacatatttaactgatgtatcataaaactacagatttagcgataaatttatccaaaaactataaatttaataataaaattatcaaacaattattgattttgggatttaaatatttagctctaattttatgtttgagttgtaaatgcccaaattgtgtgattacattgatataaaacatgtagttttgtgataactttgttactaaatgtgtaattttgcgatattccaccttaaatctgtagttctgtgataaatttaatgttaaatatgtagtattatgaaacatcatgtcaaatctgtaggtttctgataatttggctaaagtagtgaaattcactcttattttttttagaaaaagaattattgggtcattagacaaaatccatatgttaaaaaaaagagaaattttatggttcttaagaaagcacttgtagacatcaaaattttacataaaagttaagtgtaatacctagtatctggagatatcaagttttacacttagaaaaatatgttatctcctaatatcttaagggcccctttgaatcataggaatgaaaaaaacggaggaataggaaaaacataagattctgacaggaatgcaagtgtaaaagagaggattgcaaaacacaggaaaaacataggaatgactatttgattgggccataggaaaaatacaggaatttgaggagagataaagactcaaaggattctttccatgaggttctaccttatgttaaatttcctccgaaacttgcatggaaagagtcattccataggaatttcataggatttcataagatccattcctttaattcaaatggctatataggaaaaatttatataggaatgaactcctctaaaattcctatgaattttctttgaatcaaaggggccctaagtatggtaaacttatcctaaagcatacattgatcagctcctaaaaataaaataataatgtaccccaagagtttgcaagaaatgtgccggcaatattggattgttggaattgaatcaagaccggcagggtaccacaatatatggcaaacataggattgtgcaaaatttttaatggcaaattaaacaggtcattcttcttatgcttttgtggttagtctaggcaaaggcaatgatgtcctgtacaactccaggcacagatatgaaccagcgtaacgttcaaatatggggaaaataaatggaacatcatgaataataacaaactgagggagtaaaaatacggtgataataatagggatgattacacatgtcgaacgttgtgtaactgacaaaactggagcattttaagctgaactccccatatctattctgatttccaactgtgcagataatcggtaacatcgcggccgtgtcatcctcgctgcacgtcggcaaagctggcccaatggtacacacgggcgcgtgcatcgccgccatcttcggccagggcgggtcgcgcaagtacggcctcacctgccgctggctgcgctacttcaagaacgaccgcgaccgccgtgatctcgtcaccataggcgccggcgcaggtgtcaccgcggctttccgcgcccccgtcggcggcgtcctgttcgctctcgaatcactctcgtcatggtaaaactacccatcaaattacacatgaatgatatgcactgctgcaattttctttttctgttcatcctctgaagcttttggctgacaacttaattacaagaatgtataatttgtggctgataattaatcaaggtggcggagcgcgctgatctggcggtcgttcttcacgacggcggtggtggcggtggtgctgcggatgttcatcgagctgtgcgcgtcggggaagtgcgggctgttcggcaagggtgggctgatcatgtacgacgtcagcaccaagtttgatgacctcatgacctaccacctcaaggacatccccatcgtcgtcctcatcggcgtgatcggcgccatcttgggcgccctctacaacttcctcatgatgaaggtcctgcgcgtctacagcgtgatcaacgagtatggctagctagctacgatcattccatatctttgccaatttcacatggcttacttgttcgttcaattaattaattatgacatcatttggaacacattgaagttgaactgattatattctagtgaaaaatccaatccaatccaatgaaattaatttttgaaatgtgcaggaggggcaacgcgcacaagctgcttctggcggcggtggtgtccatcctgacgtcgtgctgcgtgttcggcctgccgtggctggcgccgtgccggccgtgcccgacagccggggcgccgtcgccgccgaacgggacgtgccattcgctgaaccgattccggcggttccactgcccggcggggcactacaacgacttggccagcctcttcctcaacatcaacgacgacgccatccgcaacctctactccacgggcaccaacgacgtctaccacccgggctccatgctcgcctttttcgtcgcctcctacgcgctcggcgtgctcagctacggcgtcgtcgcgccgtcggggctgttcgtccccatcatcctcaccggcgccacctacggccgcctcgtcgccatgctgctcggcggccgctcaggactcgaccacggcctcgtcgccatcctcggctccgcctccttcctcggcggcacgctccggatgacggtgtccgtgtgcgtcatcatcctggagctcaccaacaacctgctcctcctcccgctcgtcatgctcgtgctgctcatctccaagaccgtcgccgactccttcaactccagcatctacgacctcatcctcaatctcaagggcctcccgcacctcgacggccacgccgagccgtacatgcggcagctcaccgtcggcgacgtggtggccgggccgctgcggagcttcaacggcgtcgagaaggtgggccacatcgtgcacacgctccggaccacggggcaccacgcgttcccggtggtcgacgagccgcccttctcgccggcaccggtgctgtacggcctcgtgctgcgcgcgcacctgctggtactgctcaagaagcgggagttcctgacggcgccggtgcggtgccccaaggactacatggccgggaggttcgaggcgcaggacttcgacaagcgcgggtccgggaagcaggacaccatcgccgacgtggagctgtcgccggaggagatggagatgtacgtcgacctgcaccccttcaccaacacgtcgccgtacacggtggtggagaccatgtcgctggccaaggcgctcgtcctcttccgcgaggtcggcctgcgacacctcctcgtcgtgcccaagtcctgcgacgtatgtgaatcgatgtccactactcaaattactaacacacacctgctccaatccaaattacaaattacttaaccttttgttccactgttacaaactctcattcgaataagatcgttgcagaggtcgccggtggtggggatcctgacgaggcacgacttcatgccggagcacatcctcgggctgcacccggtgctggtgggaagccggtggaagcggctccggtggcagaagggcgccgtcgccaagaaattccggtcgctcctcgactggctagccaacgacagcggctgatcgatcgatgcagaggagtacattatattgatacacgcacatacattctggccggacaacgagggatgatgatgatggagtgcttgcacataaatatacgtacatacacgttggattggtcattgagtttttgtgaattttgtgcaataataacagcacctatacctggtggtcatgaatgacatagacacaatcattcaattttcttttcttctttttgcttgtatattactccctctattttatattataagttgttttgatttttt</dnaseqindica>|
| |
| − | Link = [http://www.ncbi.nlm.nih.gov/nuccore/NM_001068028.1 RefSeq:Os08g0300300]|
| |
| − | }}
| |
| − | [[Category:Genes]] | |
| − | [[Category:Japonica mRNA]]
| |
| − | [[Category:Oryza Sativa Japonica Group]] | |
| − | [[Category:Japonica Genes]]
| |
| − | [[Category:Japonica Chromosome 8]] | |
| − | [[Category:Chromosome 8]]
| |
