Difference between revisions of "Os04g0622600"
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==Annotated Information== | ==Annotated Information== | ||
===Function=== | ===Function=== | ||
| − | + | The Xa1 gene in rice confers resistance to Japanese race 1 of Xanthomonas oryzae pv. oryzae, the causal pathogen of bacterial blight (BB). We isolated the Xa1 gene by a map-based cloning strategy. The deduced amino acid sequence of the Xa1 gene product contains nucleotide binding sites (NBS) and a new type of leucine-rich repeats (LRR); thus, Xa1 is a member of the NBS-LRR class of plant disease-resistance genes, but quite different from Xa21, another BB-resistance gene isolated from rice. Interestingly, Xa1 gene expression was induced on inoculation with a bacterial pathogen and wound, unlike other isolated resistance genes in plants, which show constitutive expression. The induced expression may be involved in enhancement of resistance against the pathogen. | |
===Expression=== | ===Expression=== | ||
Revision as of 09:46, 7 June 2014
Xa-1 is one of bacterial blight resistance genes in rice. Although at least 38 resistance genes have been identified, Xa-1 is specific to X. oryzae pv. Oryzae. Xa-1 can be considered as a dominant resistance gene[1].
Contents
Annotated Information
Function
The Xa1 gene in rice confers resistance to Japanese race 1 of Xanthomonas oryzae pv. oryzae, the causal pathogen of bacterial blight (BB). We isolated the Xa1 gene by a map-based cloning strategy. The deduced amino acid sequence of the Xa1 gene product contains nucleotide binding sites (NBS) and a new type of leucine-rich repeats (LRR); thus, Xa1 is a member of the NBS-LRR class of plant disease-resistance genes, but quite different from Xa21, another BB-resistance gene isolated from rice. Interestingly, Xa1 gene expression was induced on inoculation with a bacterial pathogen and wound, unlike other isolated resistance genes in plants, which show constitutive expression. The induced expression may be involved in enhancement of resistance against the pathogen.
Expression
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Evolution
Please input evolution information here.
You can also add sub-section(s) at will.
Structure
- The composite nucleotide sequence of the Xa1 cDNA encoded a 5,406-bp ORF that was flanked by 59 and 39 untranslated regions of 112 and 392 bp, respectively. The nucleotide sequence of the 13.5-kb EcoRI-BamHI genomic fragment was also determined and compared with that of the cDNA sequence. The Xa1 gene was composed of four exons separated by three introns.
- The C-terminal half of Xa1 gene is composed of LRR, the common motif of the several classes of resistance genes.
- XA1 protein contains 22 potential N-linked glycosylation sites. Six of these sites are at amino acid position 36 of each LRR repeat. These structural characteristics suggest that the Xa1 product interacts with other proteins in a defense reaction–signal transduction pathway[2].
Labs working on this gene
- Department of Agriculture, Kyushu University, 6-10-1, Hakozaki, Higashiku, Fukuoka 812, Japan
- Rice Genome Research Program, National Institute of Agrobiological ResourcesySociety for Techno-innovation of Agriculture, Forestry and Fisheries, Kannondai, Tsukuba, Ibaraki 305, Japan
- National Institute of Agrobiological Resources, 1-2-1, Kannondai, Tsukuba, Ibaraki 305, Japan
- Plant Breeding Laboratory, Department of Agriculture, Kyushu University, Hakozaki, Higashiku, Fukuoka 812-81, Japan
References
- ↑ Yoshimura S, Umehara Y, Kurata N, et al. Identification of a YAC clone carrying the Xa-1 allele, a bacterial blight resistance gene in rice[J]. Theoretical and Applied Genetics, 1996, 93(1-2): 117-122.
- ↑ oshimura S, Yamanouchi U, Katayose Y, et al. Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation[J]. Proceedings of the National Academy of Sciences, 1998, 95(4): 1663-1668.
Cite error: <ref> tag with name "ref3" defined in <references> is not used in prior text.
Structured Information
| Gene Name |
Os04g0622600 |
|---|---|
| Description |
Similar to XA1 |
| Version |
NM_001060453.1 GI:115460635 GeneID:4337041 |
| Length |
24820 bp |
| Definition |
Oryza sativa Japonica Group Os04g0622600, complete gene. |
| Source |
Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
clade; Ehrhartoideae; Oryzeae; Oryza.
|
| Chromosome | |
| Location |
Chromosome 4:32036440..32061259 |
| Sequence Coding Region |
32036638..32036944,32037050..32037359,32038010..32040669,32041690..32042325,32059375..32060870 |
| Expression | |
| Genome Context |
<gbrowseImage1> name=NC_008397:32036440..32061259 source=RiceChromosome04 preset=GeneLocation </gbrowseImage1> |
| Gene Structure |
<gbrowseImage2> name=NC_008397:32036440..32061259 source=RiceChromosome04 preset=GeneLocation </gbrowseImage2> |
| Coding Sequence |
<cdnaseq>atggaggaggtggaagccggttggctggagggcgggatcaggtggctggcggagaccatcctggataacctggacgccgacaagctggatgaatggattcgccagattaggctcgccgctgacaccgagaagctacgggctgagatcgagaaggtggatggggtggtggctgccgtgaaggggagggcgatcgggaacaggtcgctggcccgatcgctcggccgtctcagggggttgctgtacgacgccgacgatgcggtcgacgagctcgactacttcaggctccagcagcaggtcgagggaggagttactacacggtttgaggctgaagagacggtcggagatggagcagaggacgaggacgatattccgatggacaatactgatgtaccggaggcagtggcggcaggcagcagcaagaaacggtccaaggcatgggaacactttactaccgtagagttcactgctgacgggaaggattctaaagcacggtgcaagtactgccacaaggacctatgttgcacatctaagaacgggacatcagctttgcgcaaccatctcaatgtttgcaagaggaaacgtgtaacaagtactgaccaaccggtaaatccatcaagtgccggtgagggtgcatcaaatgcaactggtaattcagttggcagaaaaaggatgagaatggatgggacttcaacacaccacgaggcagttagcacgcacccttggaacaaggctgaactttccaacaggatccaatgcatgactcatcagttagaagaggctgtaaatgaggttatgaggctatgtcgatcctcaagttcaaaccagagtcgacagggtacaccaccggccacaaatgcaacaacatcgtcttatcttccggagcccatagtgtatgggagggctgcagagatggaaaccatcaaacagctgatcatgagcaatagatctaatggcataaccgtcctgccaattgtaggcaatggagggataggaaaaaccactttggcgcaactggtctgcaaagatctggtaattaaaagtcagtttaatgttaagatatgggtgtatgtatctgataaatttgatgtagttaagattacaaggcagattttggatcatgtctccaaccagagccacgaaggaataagcaaccttgatacgcttcagcaggatcttgaggaacaaatgaaatctaagaagttcctcattgtcttagatgatgtgtgggaaatccgtacagatgactggaaaaaactactggctcctttaagacctaatgatcaggtgaattcgtcacaggaagaggcaacaggtaatatgataattttgacaactcgtatacagagtattgccaaaagtcttggaacagtacaatcaattaagttagaagctctgaaagatgacgatatatggtcactatttaaagtgcatgcttttggtaatgataaacatgatagtagtccaggcttacaggttcttgggaagcaaattgctagcgagctaaaaggcaacccactggcagcaaaaactgtgggttcactattaggaacgaatcttaccatcgatcattgggatagcattataaagagtgaagaatggaaatccctgcaacaagcttatggcatcatgcaagcgctgaagttgtgctatgatcatctatccaaccccttacagcaatgcgtctcttattgttctcttttccccaagggttattctttcagcaaagcacaactaatacaaatatggattgctcaaggatttgtggaagaatccagtgagaagttggagcagaaaggatggaaatatctagctgagttggtaaattcgggtttccttcagcaagttgaaagcacacggttttcatcagaatattttgttgtgcacgatcttatgcatgatttagcgcaaaaggtttcacaaacagaatatgcaactatagatggctcagagtgcacagagttagccccaagtatacgccatttgtcaatagtaactgattctgcataccgcaaggagaaatatagaaacatatctcgtaatgaggtgtttgagaaaaggttgatgaaagttaagtcaaggagtaagttgaggtcactggtattaattgggcaatatgattctcatttttttaaatatttcaaagatgctttcaaggaagcacaacatctgcgactgctgcagatcactgcaacttatgctgattctgattcatttctctccagtttggtaaattctacacatctccggtatctgaaaattgtgactgaagaatccggcagaactttgccccgatctctaaggaagtattaccatcttcaagtactagatattggctatagatttggaattccccgtatatctaatgatataaataatcttctcagcctgcggcatcttgttgcatatgatgaagtgtgttcttccattgctaacattggtaaaatgacctcacttcaggaactaggcaattttattgttcagaataatttaagtggttttgaggtgacacaattgaaatccatgaacaagcttgtacaacttagtgtgtctcaacttgaaaatgttagaactcaggaggaggcatgtggggcaaaactgaaagacaaacaacacttagaaaagctacatttgtcctggaaggatgcatggaatggatatgacagtgacgaaagctatgaagatgaatacggcagtgatatgaatatagaaacagaaggggaggaactgtcagttggtgatgccaatggtgcccaaagcttacaacatcacagtaatataagctctgaacttgcttcaagtgaggtgctcgaaggtcttgaaccacatcacggcctcaagtatctacggatatctgggtataatggatctacctccccaacttggcttccttcttcacttacctgtctgcaaacacttcatctagaaaaatgtggaaaatggcaaatacttcctttagaaaggctagggttacttgtaaagctcgtgttgatcaaaatgaggaatgcaacagaactctcaatcccttcactggaggagcttgtgttaattgcattgccaagcttgaacacatgctcctgcacttccatcaggaacttgaactccagtttaaaggttctgaaaattaagaattgccctgtactgaaggtatttcccttgtttgagatttgccagaaatttgaaatcgagcggacgtcgtcatggttgccccatcttagcaagcttaccatctataattgtcctctttcctgtgtgcacagttctctgccaccttcatctatcagcggccatgaagaagatggaatgtgtatccttccgcaatcacttgaggaaatttacatctgcgagtactctcaagagaggctgcagctctgctttccaggaagcctcacccgcctgaaaaaactagtagtgttgggaaaccaaagtttaacatctctgcagctccattcctgcacagcactccaagagttgataattcaaagctgtgagtcgcttaattctctggaaggcttgcaatggctcggcaacctcaggttgctgcaggcacacagatgcctcagtggttatggagaaaatggaaggtgtatccttccacaatcacttgaggaactttacatcagagagtattctcaagaaacgctgcagccctgctttccagggaacctcaccagcttgaaaaaactagaagtacagggaagccaaaagttaatatctctgcagctgtattcctgcacagcactccaagagttgatgattgaaagttgtgtgtcgcttaattctctggaaggcctgcaatggctcgtcaacctcaggttgctgcgggcacacagatgcctcagtggttatggagaaaatggaaggtgtatccttccacaatcacttgagggactttacatcagagagtattctcaagaaacgctgcagctctgctttccaggaaacctcacccgcctgaaaacactagtagtgttgggaaaccaaagtttaacatctctgcagctccattcctgcacagcactccaagagttgataattcaaagatgtgaatcacttaattctctggaaggtttgcaattgctcggcaatctcagggggctgctggcacacagatgcctcagcggccatggagaagatggaaggtgtatccttccgcaatcacttgagaaactttacatctgggagtactctcaagagaggctgcagctctgctttccaggaaacctcacccgccagaaaatactaggagtgttgggaagccaaagtttaacatctctgcagctccattcctgcacagcactccaagagttgatgattcgaagctgtgaatcgcttaattctctggaaggcttgcaatggctcggcaacctcagggtgctgcgggcacacagatgcctcagtggttatggagaatatggaaggtgtacccttccgcaatcacttgaggaactttacatccatgagtattctcaagaaactctgcagccctgcttttcagggaacctcactctcctgagaaaattacaagtaaaggggaactcaaatttagtgtctctgcagctccattcttgcacatcactccaagagttgataattgaaagctgtaagtcaattaattcgctggaaggcttgcaatcgcttggcaacctcaggttgttgcgggcattcagatgcctcagtggttatggagaatatggaaggtgtatccttccgcaatcacttgaggaacttttcatcagtgagtattctctagaaactctgcagccctgcttcctgacgaatctcacctgcttaaaacaattagaggtatcaggcaccacaagtttaaaatctctagaactgcaatcatgcactgcactcgaacatttgaagattcaaggttgtgcgtcgcttgctacattggaggggttgcaattcctccacgccctcaggcatatggaagtattcagatgccctggcttgcctccatatttggggagttcgtcagagcagggctatgagctatgcccacgactggaaaggctcgacatcgatgacccctctatccttaccacgtcgttctgcaagcacctcacctccctccaacgcctagagcttaactatcgcggaagtgaagtggcaagactaacggatgagcaagagagagcgcttcagctcctattgtccctgcaagagctccggtttaagtcttgctacgatctcgtagatcttcctgcggggctccacagccttccctccctcaagaggttggagatctggtggtgcaggagcatcgcgaggctgccagagatgggcctcccaccttcgttggaagaactggttatcgtagattgcagtgacgagctagctcatcagtgcagaactctagcaagcaagctgaatgtcaaaattaatggggaatatgtgaactga</cdnaseq> |
| Protein Sequence |
<aaseq>MEEVEAGWLEGGIRWLAETILDNLDADKLDEWIRQIRLAADTEK LRAEIEKVDGVVAAVKGRAIGNRSLARSLGRLRGLLYDADDAVDELDYFRLQQQVEGG VTTRFEAEETVGDGAEDEDDIPMDNTDVPEAVAAGSSKKRSKAWEHFTTVEFTADGKD SKARCKYCHKDLCCTSKNGTSALRNHLNVCKRKRVTSTDQPVNPSSAGEGASNATGNS VGRKRMRMDGTSTHHEAVSTHPWNKAELSNRIQCMTHQLEEAVNEVMRLCRSSSSNQS RQGTPPATNATTSSYLPEPIVYGRAAEMETIKQLIMSNRSNGITVLPIVGNGGIGKTT LAQLVCKDLVIKSQFNVKIWVYVSDKFDVVKITRQILDHVSNQSHEGISNLDTLQQDL EEQMKSKKFLIVLDDVWEIRTDDWKKLLAPLRPNDQVNSSQEEATGNMIILTTRIQSI AKSLGTVQSIKLEALKDDDIWSLFKVHAFGNDKHDSSPGLQVLGKQIASELKGNPLAA KTVGSLLGTNLTIDHWDSIIKSEEWKSLQQAYGIMQALKLCYDHLSNPLQQCVSYCSL FPKGYSFSKAQLIQIWIAQGFVEESSEKLEQKGWKYLAELVNSGFLQQVESTRFSSEY FVVHDLMHDLAQKVSQTEYATIDGSECTELAPSIRHLSIVTDSAYRKEKYRNISRNEV FEKRLMKVKSRSKLRSLVLIGQYDSHFFKYFKDAFKEAQHLRLLQITATYADSDSFLS SLVNSTHLRYLKIVTEESGRTLPRSLRKYYHLQVLDIGYRFGIPRISNDINNLLSLRH LVAYDEVCSSIANIGKMTSLQELGNFIVQNNLSGFEVTQLKSMNKLVQLSVSQLENVR TQEEACGAKLKDKQHLEKLHLSWKDAWNGYDSDESYEDEYGSDMNIETEGEELSVGDA NGAQSLQHHSNISSELASSEVLEGLEPHHGLKYLRISGYNGSTSPTWLPSSLTCLQTL HLEKCGKWQILPLERLGLLVKLVLIKMRNATELSIPSLEELVLIALPSLNTCSCTSIR NLNSSLKVLKIKNCPVLKVFPLFEICQKFEIERTSSWLPHLSKLTIYNCPLSCVHSSL PPSSISGHEEDGMCILPQSLEEIYICEYSQERLQLCFPGSLTRLKKLVVLGNQSLTSL QLHSCTALQELIIQSCESLNSLEGLQWLGNLRLLQAHRCLSGYGENGRCILPQSLEEL YIREYSQETLQPCFPGNLTSLKKLEVQGSQKLISLQLYSCTALQELMIESCVSLNSLE GLQWLVNLRLLRAHRCLSGYGENGRCILPQSLEGLYIREYSQETLQLCFPGNLTRLKT LVVLGNQSLTSLQLHSCTALQELIIQRCESLNSLEGLQLLGNLRGLLAHRCLSGHGED GRCILPQSLEKLYIWEYSQERLQLCFPGNLTRQKILGVLGSQSLTSLQLHSCTALQEL MIRSCESLNSLEGLQWLGNLRVLRAHRCLSGYGEYGRCTLPQSLEELYIHEYSQETLQ PCFSGNLTLLRKLQVKGNSNLVSLQLHSCTSLQELIIESCKSINSLEGLQSLGNLRLL RAFRCLSGYGEYGRCILPQSLEELFISEYSLETLQPCFLTNLTCLKQLEVSGTTSLKS LELQSCTALEHLKIQGCASLATLEGLQFLHALRHMEVFRCPGLPPYLGSSSEQGYELC PRLERLDIDDPSILTTSFCKHLTSLQRLELNYRGSEVARLTDEQERALQLLLSLQELR FKSCYDLVDLPAGLHSLPSLKRLEIWWCRSIARLPEMGLPPSLEELVIVDCSDELAHQ CRTLASKLNVKINGEYVN</aaseq> |
| Gene Sequence |
<dnaseqindica>199..505#611..920#1571..4230#5251..5886#22936..24431#catcagacgattaatccacgacgaccaggagcgctgccccgagccacacgcccacacgcactggtgaatcttctcctttccacctagttttcactctgcagtctcctctcctagctactactctgccttcccatcctcgcttgttgcagccctcttgcacacgccattggccacagtccaaggactgctcctgttccgatggaggaggtggaagccggttggctggagggcgggatcaggtggctggcggagaccatcctggataacctggacgccgacaagctggatgaatggattcgccagattaggctcgccgctgacaccgagaagctacgggctgagatcgagaaggtggatggggtggtggctgccgtgaaggggagggcgatcgggaacaggtcgctggcccgatcgctcggccgtctcagggggttgctgtacgacgccgacgatgcggtcgacgagctcgactacttcaggctccagcagcaggtcgagggaggaggtactgtctttgcatatatccgtgccttttaattaagtttgcaagctgcgttgcctgcaacaatggcgtattggcgtcagtttccaatccatgcttgtgctacagttactacacggtttgaggctgaagagacggtcggagatggagcagaggacgaggacgatattccgatggacaatactgatgtaccggaggcagtggcggcaggcagcagcaagaaacggtccaaggcatgggaacactttactaccgtagagttcactgctgacgggaaggattctaaagcacggtgcaagtactgccacaaggacctatgttgcacatctaagaacgggacatcagctttgcgcaaccatctcaatgtttgcaagaggaaacgtgtaacaagtactgaccaaccggtaaatccatcaaggtaatgctaatggagttctgaatttagtgtaaatccgttgaagtgtaaatttggcccgttacatctgcttaagatctcattctgtctctaatcttctaatagccaactcatggtcattttttttcctaatatatagtaccggtgatggtgcaccaaatgtaattagatgcaaggaaacaaaagtgaacaattgtatatatcaaatataattatatctaaaacatgagtagtgtatcaaatccaattctttcaaaaatctactatgcaaaattgagtgacaaaatctgctgcctttttttttttacagaaagcaaccaattaatataagtcaaatataaaaacgctttgtagtctccaataaaatagctcattgtttcgtttatacttatgtttataaatttaaatttaaaacttaattttggagttgattttgtggttttcttttcatcctattttattttacaacatttgattttgaatagttaagaatgcgtatataaaaattttacccataagttattttttaaattgttaataaatcgtaaggataatcataagtataagtgaaatgattcgctcttcatctacttaagattgcgttatattgctgacctttctaatcgcctaaccacgatcacatgctcttccagtgccggtgagggtgcatcaaatgcaactggtaattcagttggcagaaaaaggatgagaatggatgggacttcaacacaccacgaggcagttagcacgcacccttggaacaaggctgaactttccaacaggatccaatgcatgactcatcagttagaagaggctgtaaatgaggttatgaggctatgtcgatcctcaagttcaaaccagagtcgacagggtacaccaccggccacaaatgcaacaacatcgtcttatcttccggagcccatagtgtatgggagggctgcagagatggaaaccatcaaacagctgatcatgagcaatagatctaatggcataaccgtcctgccaattgtaggcaatggagggataggaaaaaccactttggcgcaactggtctgcaaagatctggtaattaaaagtcagtttaatgttaagatatgggtgtatgtatctgataaatttgatgtagttaagattacaaggcagattttggatcatgtctccaaccagagccacgaaggaataagcaaccttgatacgcttcagcaggatcttgaggaacaaatgaaatctaagaagttcctcattgtcttagatgatgtgtgggaaatccgtacagatgactggaaaaaactactggctcctttaagacctaatgatcaggtgaattcgtcacaggaagaggcaacaggtaatatgataattttgacaactcgtatacagagtattgccaaaagtcttggaacagtacaatcaattaagttagaagctctgaaagatgacgatatatggtcactatttaaagtgcatgcttttggtaatgataaacatgatagtagtccaggcttacaggttcttgggaagcaaattgctagcgagctaaaaggcaacccactggcagcaaaaactgtgggttcactattaggaacgaatcttaccatcgatcattgggatagcattataaagagtgaagaatggaaatccctgcaacaagcttatggcatcatgcaagcgctgaagttgtgctatgatcatctatccaaccccttacagcaatgcgtctcttattgttctcttttccccaagggttattctttcagcaaagcacaactaatacaaatatggattgctcaaggatttgtggaagaatccagtgagaagttggagcagaaaggatggaaatatctagctgagttggtaaattcgggtttccttcagcaagttgaaagcacacggttttcatcagaatattttgttgtgcacgatcttatgcatgatttagcgcaaaaggtttcacaaacagaatatgcaactatagatggctcagagtgcacagagttagccccaagtatacgccatttgtcaatagtaactgattctgcataccgcaaggagaaatatagaaacatatctcgtaatgaggtgtttgagaaaaggttgatgaaagttaagtcaaggagtaagttgaggtcactggtattaattgggcaatatgattctcatttttttaaatatttcaaagatgctttcaaggaagcacaacatctgcgactgctgcagatcactgcaacttatgctgattctgattcatttctctccagtttggtaaattctacacatctccggtatctgaaaattgtgactgaagaatccggcagaactttgccccgatctctaaggaagtattaccatcttcaagtactagatattggctatagatttggaattccccgtatatctaatgatataaataatcttctcagcctgcggcatcttgttgcatatgatgaagtgtgttcttccattgctaacattggtaaaatgacctcacttcaggaactaggcaattttattgttcagaataatttaagtggttttgaggtgacacaattgaaatccatgaacaagcttgtacaacttagtgtgtctcaacttgaaaatgttagaactcaggaggaggcatgtggggcaaaactgaaagacaaacaacacttagaaaagctacatttgtcctggaaggatgcatggaatggatatgacagtgacgaaagctatgaagatgaatacggcagtgatatgaatatagaaacagaaggggaggaactgtcagttggtgatgccaatggtgcccaaagcttacaacatcacagtaatataagctctgaacttgcttcaagtgaggtgctcgaaggtcttgaaccacatcacggcctcaagtatctacggatatctgggtataatggatctacctccccaacttggcttccttcttcacttacctgtctgcaaacacttcatctagaaaaatgtggaaaatggcaaatacttcctttagaaaggctagggttacttgtaaagctcgtgttgatcaaaatgaggaatgcaacagaactctcaatcccttcactggaggagcttgtgttaattgcattgccaagcttgaacacatgctcctgcacttccatcaggaacttgaactccagtttaaaggttctgaaaattaagaattgccctgtactgaaggtatttcccttgtttgagatttgccagaaatttgaaatcgagcggacgtcgtcatggttgccccatcttagcaagcttaccatctataattgtcctctttcctgtgtgcacagttctctgccaccttcatctattgtttccaaattatcgatcggtaaagtttcaacacttccaacggtgagggggtcatctagtggaacattaataattggactgcaccccgatgaagttgatgatgatgatggtttggaggattctgatcagctgaaaacgttggatgacaaagtactattattccataacctgaggttcctaactagcttggcaatatatggttgtcgaaatcttgcgactatttcaattgaaagtttaaggcaactcgtttgtttgaagagtttggaattatacggctgcccaaaacttttctcttcagatgttccaccagagcttacatgtgaatatatgtcaggagcaaatcacagcgccctcccatctctcgaatgtctctatattgaggattgtggaataacggggaagtggctgtctctgatgttgcaacatgtgcaggccctacaggaactgagtttagaggactgccagcagataacaaggctatcgataggagaggaagaaaacagtcaaccaaatcttatgtcagctatggaggatccgtcattaggatatccagatcgagacgaacttctgcgccttccgttaaatctcatctcttctctgaaaaaggtatctattacatattgctatgatttaacattctacggcagcaaggtagatttcgctggatttacctcccttgaggagttagtgatttcacgatg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