Difference between revisions of "Os10g0577600"

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==Annotated Information==
 
==Annotated Information==
 
===Bacground===
 
===Bacground===
−
Histone lysine methylation is an important epigenetic modification with both activating and repressive roles in gene expression (1). There are six lysine residues in histone N-termini that are predominantly methylated, with the methylation of histone H3 lysine 4 (H3K4) and lysine 36 (H3K36) primarily having an activating function, whereas the methylation of histone H3 lysine 9 (H3K9) and lysine 27 (H3K27) and histone H4lysine 20 (H4K20) is essentially associated with repressed chromatin (2). Histone lysine residues can be mono-, di- or trimethylated. Each distinct methyl state is associated with different biological functions (1).
+
Histone lysine methylation is an important epigenetic modification with both activating and repressive roles in gene expression <ref name="ref1">. There are six lysine residues in histone N-termini that are predominantly methylated, with the methylation of histone H3 lysine 4 (H3K4) and lysine 36 (H3K36) primarily having an activating function, whereas the methylation of histone H3 lysine 9 (H3K9) and lysine 27 (H3K27) and histone H4lysine 20 (H4K20) is essentially associated with repressed chromatin (2). Histone lysine residues can be mono-, di- or trimethylated. Each distinct methyl state is associated with different biological functions (1).
  
 
Jumonji C (jmjC) domain-containing proteins have been suggested to function as histone demethylases (5). Using biochemical approaches, the first jmjC domain-containing histone demethylase, JHDM1 (jmjC domain-containing histone demethylase 1), was identified and shown to reverse H3K36 mono- and dimethylation (H3K36me1 and H3K36me2), and the jmjC domain was demonstrated to be the catalytic domain (6). Jumonji C domain-containing histone demethylases catalyze lysine demethylation through an oxidative reaction that requires iron Fe(II) and �-ketoglutarate as cofactors.
 
Jumonji C (jmjC) domain-containing proteins have been suggested to function as histone demethylases (5). Using biochemical approaches, the first jmjC domain-containing histone demethylase, JHDM1 (jmjC domain-containing histone demethylase 1), was identified and shown to reverse H3K36 mono- and dimethylation (H3K36me1 and H3K36me2), and the jmjC domain was demonstrated to be the catalytic domain (6). Jumonji C domain-containing histone demethylases catalyze lysine demethylation through an oxidative reaction that requires iron Fe(II) and �-ketoglutarate as cofactors.

Revision as of 02:43, 5 June 2014

Please input one-sentence summary here.

Annotated Information

Bacground

Histone lysine methylation is an important epigenetic modification with both activating and repressive roles in gene expression Cite error: Closing </ref> missing for <ref> tag [1] [2] [3]


</references>

Structured Information

Gene Name

Os10g0577600

Description

Similar to PLU-1 protein

Version

NM_001072024.1 GI:115483643 GeneID:4349499

Length

5887 bp

Definition

Oryza sativa Japonica Group Os10g0577600, complete gene.

Source

Oryza sativa Japonica Group 

 ORGANISM  Oryza sativa Japonica Group
           Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
           Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
           clade; Ehrhartoideae; Oryzeae; Oryza.
Chromosome

Chromosome 10

Location

Chromosome 10:23481090..23486976

Sequence Coding Region

23482626..23483016,23483139..23483295,23483373..23483592,23483708..23483761,23483848..23483927
,23484014..23484291,23484373..23484774,23484848..23485170,23485245..23485508
,23486108..23486515

Expression

GEO Profiles:Os10g0577600

Genome Context

<gbrowseImage1> name=NC_008403:23481090..23486976 source=RiceChromosome10 preset=GeneLocation </gbrowseImage1>

Gene Structure

<gbrowseImage2> name=NC_008403:23481090..23486976 source=RiceChromosome10 preset=GeneLocation </gbrowseImage2>

Coding Sequence

<cdnaseq>atgcaacaggtggagggcaggaactgtcttcctgcggaggtcaggattggcctcgagacgctcaagaggcgccggcttgagaggatgcgtttgactgctcagaacaatgccggcgacggtcctccggtgcccgcaaggagcggtggggatgcgctaaggactcccgcaaactgcggggtcaggttgcatgctaacaatggcacagctctacctagcagaaccacccagaacaaggacccttttgcaaagcgcagggtggacaagtttgatatgtctagcctagaatggattgacaagatcgaagaatgccctgtgtactatcctaccaaggaggagttcgaggatcccattggttatatacagaagattgcacctgtggcttcgaaatacggaatttgcaaaatcgtatctccagtaagcgcttctgttcctgctggtgtcgtgttgatgaaggaacagcctggtttcaagttcatgaccagggttcagccgcttcgcctcgccaaatgggctgaagatgacacggtcactttcttcatgagcgaaagaaagtacactttccgggattatgagaaaatggccaacaaggtgttcgccaagaaatactcaagtgctagttgtctcccagctaagtacgtggaggaggaattctggcgcgaaattgcttttggtaaaatggattttgttgaatatgcctgtgatgttgatggtagtgctttctcctcttctcctcatgatcaacttgggaaaagcaactggaacttgaagaatttttcacggctttccaattctgtgcttagacttctgcagacaccaattccaggagtaacagatccaatgctttatatcgggatgctcttcagcatgtttgcttggcatgtggaagatcattatttgtacagcatcaattaccatcattgtggggcatttaagacatggtatggcataccgggtgatgctgctcctgggtttgaaaaggtggctagccagtttgtatacaacaaggatattttggttggtgaaggagaggatgcagcatttgatgttctcttggggaagacaacaatgttccccccaaatgtcttgttagaccacaacgttcctgtttataaagctgtgcaaaaacctggggagtttgtcattactttccctcgttcctaccacgcgggtttcagccacggcttcaattgtggcgaggctgtcaactttgctatcagtgactggtttcctctgggttctgtggccagcagacgctacgcgcttctgaacagaacacccttgcttgcacacgaggagttactttgccgttctgcagtgcttctgtcccacaaactgttaaacagcgacccaaaatccctcaataaatctgagcatccacattcacagcgttgtttgaagtcttgctttgtgcagttgatgcgattccagagaaacacacgtggcctacttgctaaaatgggctctcagatacattataagccaaaaacatacccgaatctctcatgtagcatgtgtcggcgtgattgctacattacacatgtgttgtgtggatgcaactttgacccagtctgtcttcatcacgaacaagaactccggagctgcccttgtaaatctaaccaggttgtctacgttagggaggacatacaggagctagaagctctatcaagaaaatttgagaaggatatttgcttggataaggaaataagtggttttgactcatacaagcaggccgaaaagaatgagccattttttgagataactcggaacctcaggaacactgaagtaaatttgatagaggatgccttctcaggagcaactgctgctgatgctgcaaagagttctcctgcaacgtcaacactgacatcttttgcacaacatgatgtgcctgttcttgctgaagcaattgtctgtgctaatcaagccgaccaattatactccaccaccgagcaaaccatcagctcacctttagtcaaaggaactgatgctgtgggtgcaaattcatccagcatggctgatgctaataacggaactggttcttgtaatgcttcagctgtggaatacagtggaaattcagattctgaatctgaaatatttcgagtcaagcgcaggtctggcgtatcagtaaagcctgcatctgatgccaagacatcaaacttgtctgatcaacaggttctcaggcggttgaagaaggtgcgccctgaaatacaacagcacaataagcgaccagaagactatggtcactgttcagttccctcaggtcgtatgagtatgaagaatttgaattcatcctcctcatgtggtgaagaacactggaggatgaagcggcggcagttggagactcagcaggatgagagcagttattctgcaaagcagaagtcgtactcgtatccatccaccagctattctttccgaggagagtttgtggaaatgagtagagatgctgctgcagaagtccgaccaaagcgactgaaaatccggctaccttcttctagcacgaacagagtggttgagcagggcagttcagggcaaagatttacaagggatgacaagtcgcttggttgttggcctgcaatttag</cdnaseq>

Protein Sequence

<aaseq>MQQVEGRNCLPAEVRIGLETLKRRRLERMRLTAQNNAGDGPPVP ARSGGDALRTPANCGVRLHANNGTALPSRTTQNKDPFAKRRVDKFDMSSLEWIDKIEE CPVYYPTKEEFEDPIGYIQKIAPVASKYGICKIVSPVSASVPAGVVLMKEQPGFKFMT RVQPLRLAKWAEDDTVTFFMSERKYTFRDYEKMANKVFAKKYSSASCLPAKYVEEEFW REIAFGKMDFVEYACDVDGSAFSSSPHDQLGKSNWNLKNFSRLSNSVLRLLQTPIPGV TDPMLYIGMLFSMFAWHVEDHYLYSINYHHCGAFKTWYGIPGDAAPGFEKVASQFVYN KDILVGEGEDAAFDVLLGKTTMFPPNVLLDHNVPVYKAVQKPGEFVITFPRSYHAGFS HGFNCGEAVNFAISDWFPLGSVASRRYALLNRTPLLAHEELLCRSAVLLSHKLLNSDP KSLNKSEHPHSQRCLKSCFVQLMRFQRNTRGLLAKMGSQIHYKPKTYPNLSCSMCRRD CYITHVLCGCNFDPVCLHHEQELRSCPCKSNQVVYVREDIQELEALSRKFEKDICLDK EISGFDSYKQAEKNEPFFEITRNLRNTEVNLIEDAFSGATAADAAKSSPATSTLTSFA QHDVPVLAEAIVCANQADQLYSTTEQTISSPLVKGTDAVGANSSSMADANNGTGSCNA SAVEYSGNSDSESEIFRVKRRSGVSVKPASDAKTSNLSDQQVLRRLKKVRPEIQQHNK RPEDYGHCSVPSGRMSMKNLNSSSSCGEEHWRMKRRQLETQQDESSYSAKQKSYSYPS TSYSFRGEFVEMSRDAAAEVRPKRLKIRLPSSSTNRVVEQGSSGQRFTRDDKSLGCWP AI</aaseq>

Gene Sequence

<dnaseqindica>1537..1927#2050..2206#2284..2503#2619..2672#2759..2838#2925..3202#3284..3685#3759..4081#4156..4419#5019..5426#ctctttcctcctccgccgcccgcccgcccattgccgagctccccgccgcacgccccagctaactaccactccggcacggcagggcagggcagggctcgccgccggaggggaatgtggcatccttaccttccccccttgccgtaaaacaaagaaagaaagtctcccgtctcggctccttgcgccatcgtcgacaggggaggggaggtggcgagcagtagcaggggaggggatcctccaggtgaccatcctctttctcacaaattcttctctctcccaccgggactacaatttgcttgcgttccttaatttcgcaccctcttttagatctggtgcaagaagctcttctcctccttaatttcgcaccctcctttaccgcaatactacaatctagtttgttgtctgttcccccccatccaatttaccctagattcctcatcaaatcacaccattttccctcaccctcctcagccccacggattaccgccttctttttcttactactaattgccgtccgtccgttgatgtttggaaaaagtaccacttttcttcttccttaatcttaatttgacgacgacgcgtagaggagaggaggtacagaaccaccggtatctaatcaaacagagacaagaaagttggaatcctaatttggccccgggtcgctgcaacagaatgcaagactagattgacacctagatttaccttaccttagaccgggccacaagtcaacgcgctcaattcatttcatttaccaccacaccactagtcgttcctccatcctggagtactactgtagtaggagtagtttttagtattcattactctctgtatggatgggatattactactactgtagtagagtagtcaagaggcggtcttccattcttgccgtgtggggttcagggggcatctcctctcctctcatctttcttttttgacgatttcttcgtctctctaaaatggcctggtcatatcgcatgtgcgtaattccccccctctgaccacgtccagtccactgcaaaaattttaaccttttcttctctttttctcttccaaggccctacatttttgtactactccacatttatatgcccttcttctcctcatcctcaatctgaatccgccgttattttctctctctaactcatgtaatggtttctgttcgtgtgagcacccaccattgccacgaatcgttagagatgcagcactgctaccattttttatacaactaaaatactaatacaattaattaatggctggttgattgtgacttctggctgtggtaggggaaaaccaccccaatgtgccgtgtctgaatccaatactgtagctttctttgacttggttgggacttgcccttctttcggtgctacctggctgtgaccaattcatacaaaccgttggtgcttgttcactctgctgtctctgttggtcaatgccactggccttcccagattttgcacatgaaccttcttcgttgctccttcattccgtaatgtgtccgtttacctatgcaacaggtggagggcagaaacacctatgcaacaggtggagggcaggaactgtcttcctgcggaggtcaggattggcctcgagacgctcaagaggcgccggcttgagaggatgcgtttgactgctcagaacaatgccggcgacggtcctccggtgcccgcaaggagcggtggggatgcgctaaggactcccgcaaactgcggggtcaggttgcatgctaacaatggcacagctctacctagcagaaccacccagaacaaggacccttttgcaaagcgcagggtggacaagtttgatatgtctagcctagaatggattgacaagatcgaagaatgccctgtgtactatcctaccaaggaggagttcgaggatcccattggttatatacagaagattgcacctgtggcttcgaaatacggtactgcttccgtttctcgttgccctcatcgtctgttgacagtgtattactgattgatctgccagtctacgcagaatcttactttctaaatgaatgatcatgggctattattttctccccaggaatttgcaaaatcgtatctccagtaagcgcttctgttcctgctggtgtcgtgttgatgaaggaacagcctggtttcaagttcatgaccagggttcagccgcttcgcctcgccaaatgggctgaagatgacacggtcactttcttcatgagcgaaaggtgtggtatttcttggttcattttcattattggctgcttatctcccaggtctcatgatgcttggcatgattttgcagaaagtacactttccgggattatgagaaaatggccaacaaggtgttcgccaagaaatactcaagtgctagttgtctcccagctaagtacgtggaggaggaattctggcgcgaaattgcttttggtaaaatggattttgttgaatatgcctgtgatgttgatggtagtgctttctcctcttctcctcatgatcaacttgggaaaagcaactggaacttgaaggtgactaactctcttctgtgtttgtgtgtgtggatgtgtcgtcacatgagtgcatgtttaaatatttgctcactggtagtatgtgttttactgatcgtatttttttgtttcgtagaatttttcacggctttccaattctgtgcttagacttctgcagacaccaattccagtaagtcatttatttactacttaatgtgtttcacattctttaacatggccaaaatttcatgattgtattacactcatccaaaacagggagtaacagatccaatgctttatatcgggatgctcttcagcatgtttgcttggcatgtggaagatcattatttgtacaggtataaattctcggttctccatggttactctttcttttttgctcgtaattaatactggtgttctgacattttattcatatgaccagcatcaattaccatcattgtggggcatttaagacatggtatggcataccgggtgatgctgctcctgggtttgaaaaggtggctagccagtttgtatacaacaaggatattttggttggtgaaggagaggatgcagcatttgatgttctcttggggaagacaacaatgttccccccaaatgtcttgttagaccacaacgttcctgtttataaagctgtgcaaaaacctggggagtttgtcattactttccctcgttcctaccacgcgggtttcagccacggtatgtatctttcagtttgtgcatgtgttataacgccactatcatatgcatagtattctaaggaatgtttcaactacccaggcttcaattgtggcgaggctgtcaactttgctatcagtgactggtttcctctgggttctgtggccagcagacgctacgcgcttctgaacagaacacccttgcttgcacacgaggagttactttgccgttctgcagtgcttctgtcccacaaactgttaaacagcgacccaaaatccctcaataaatctgagcatccacattcacagcgttgtttgaagtcttgctttgtgcagttgatgcgattccagagaaacacacgtggcctacttgctaaaatgggctctcagatacattataagccaaaaacatacccgaatctctcatgtagcatgtgtcggcgtgattgctacattacacatgtgttgtgtggatgcaactttgacccagtctgtcttcatcacggtaggaaatgttagcattgctcttttgcactttcttttgtattttacctaatactttggttattggactgcagaacaagaactccggagctgcccttgtaaatctaaccaggttgtctacgttagggaggacatacaggagctagaagctctatcaagaaaatttgagaaggatatttgcttggataaggaaataagtggttttgactcatacaagcaggccgaaaagaatgagccattttttgagataactcggaacctcaggaacactgaagtaaatttgatagaggatgccttctcaggagcaactgctgctgatgctgcaaagagttctcctgcaacgtcaacactgacatcttttgcacaacatgatgtgcctgttcttgctgaagcaattgtaggtttaccatcatgcatatatttccagctgttatctttctgttgggttaatgttcttgttattttatttaggtctgtgctaatcaagccgaccaattatactccaccaccgagcaaaccatcagctcacctttagtcaaaggaactgatgctgtgggtgcaaattcatccagcatggctgatgctaataacggaactggttcttgtaatgcttcagctgtggaatacagtggaaattcagattctgaatctgaaatatttcgagtcaagcgcaggtctggcgtatcagtaaagcctgcatctgatgccaagacatcaaacttgtctgatcaacaggtacgttaaattttcatcttttacacccctttggcttatcatcaacttttaggtactccctccggttctaaattaattgacgttttggacaaggttgagatcaattttttataactttgaccatcaataactttaaaaatatttagtttaaagaaactaaaacaacatatatagatttgtcttttaaagcactataataaaagtaaacatgtatttatttattatatatattatagtagaaaaataaggtcaaagatatatcttgtagaccgtgtcattgtccaaaatgtcaattaaaatggaaccggagggagtaattgcactgtttaagggaaaatacttcatgtaagaataaatgacatgctatataaatggccaggcatctccagttgtcgaggtcatttgatagataataatgggcaatcatgtcataaataaataagttgcagctctagttatgtattaattaagttcctgtaccattttacaccaaggtccaagggtctttatatgaaggatgacatacgggcccatagcatttagttgtcctattttagatagtgcttacttttggttctgatgtaaaatactggaatcaggttctcaggcggttgaagaaggtgcgccctgaaatacaacagcacaataagcgaccagaagactatggtcactgttcagttccctcaggtcgtatgagtatgaagaatttgaattcatcctcctcatgtggtgaagaacactggaggatgaagcggcggcagttggagactcagcaggatgagagcagttattctgcaaagcagaagtcgtactcgtatccatccaccagctattctttccgaggagagtttgtggaaatgagtagagatgctgctgcagaagtccgaccaaagcgactgaaaatccggctaccttcttctagcacgaacagagtggttgagcagggcagttcagggcaaagatttacaagggatgacaagtcgcttggttgttggcctgcaatttagaatttagaaaaaaatgctgacgcaggtgctaacctctgatggagataaagatttccttgtttaggtggggctgttgactacacgaaatgatagggctgggatggatcgatgaggttgaatataaatgattagcacagaagctgactgactttagaaggctggttaatcgattctttgtgcagcagtgcctccaatttgaggcacatctaggcacggttagaagagacagacacatgacgattcttgttgctggaggttctgggtcactgctttgctgctgtttgatgcctgcactgcaagtgacgtacacacactataggacctcgctctaccctttgattatatctctctatttttcttcttctttgtcagcaaccttagctgctgctactctatagctaactgtattctttcatacgcttgttccatcaagttaatctgctgcttaatgccattgattc</dnaseqindica>

External Link(s)

NCBI Gene:Os10g0577600, RefSeq:Os10g0577600

  1. ↑ Tsukada Y, et al. (2006) Histone demethylation by a family of JmjC domain-containing proteins. Nature 439:811–816.
  2. ↑ Chen Z, et al. (2006) Structural insights into histone demethylation by JMJD2 family members. Cell 125:691–702.
  3. ↑ Klose RJ, Kallin EM, Zhang Y (2006) JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 7:715–727.
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