Os04g0504000

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Annotated Information

Function

the rice gene, Os04g0504000,or named OsAPT2,contains seven exons and six introns.And it encodes a putative adenine phosphoribosyl transferase( APRT).The deduced amino acid sequence of Os04g0504000is highly homologous to those of previously isolated APRTs.The observed heat-induced change in the Os04g0504000expression pattern in young panicles may mediate, at least in part, thermo-sensitive genic male sterility( TGMS)in 'Annong S-1'.the Os04g0504000is likely to be involved in TGMS in the rice line 'Annong S-1'.

Expression

the gene, Os04g0504000 encodes a putative a putative adenine phosphoribosyl transgerase (APRT). In plants, adenine phosphoribosyl transferase (APRT) is the primary enzyme that converts adenine into adenosine-5'-monophosphate( AMP) in the salvage metabolism pathway. The balance of adenosine triphosphate( ATP) in the cell is maintained by two biosynthetic pathways: de novo adenine biosynthesis and purine salvage pathway, adenine may be converted to AMP via two possible pathways" a single step pathway involving APRT activity and a two-step pathway involving the sequential action of adenosine phosphorylase and adenosine kinase( ADK). the single step APRT pathway is the predominant pathway for the salvaging of adenine in plants under stress conditions.In contrast to the de novo purine biosynthetic pathway, purine salvage is more efficient due to its ability to convert adenine, a byproduct of many biochemical reactions, into AMP.The mutant of the gene Os04g0504000 is male sterile due to abortion of pollen development after the meiotic division of the pollen mother cell.and it is likely to be involved in TGMS in the rice line 'Annong S-1'.

Evolution

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Labs working on this gene

The State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,CAS.

References

1. Chun-Jiang Zhou, Jun Li and Ji-Cheng Zou.2006.Cloning and characterization of a second form of the rice adenine phosphoribosyl transferase gene (OsAPT2) and its association with TGMS.Plant Molecular Biology (2006) 60:365–376
2. WENG Man-li,WANG Wang and ZHOU Chun-jiang.Cloning and genetic transformation of a novel rice gene OsAPT2.Journal of Hunan Agricultural University (Natural Sciences)(2007)33.

1. 闫成业;刘艳;牟同敏

 分子标记辅助选择聚合Xa7、Xa21和cry1C*基因改良杂交水稻金优207的白叶枯病和螟虫抗性
 杂交水稻, 2013, 28(5): 52-59

2. Yanchang Luo;Jatinder S. Sangha;Shouhai Wang;Zefu Li;Jianbo Yang;Zhongchao Yin

 Marker-assisted breeding of Xa4, Xa21 and Xa27 in the restorer lines of hybrid rice for broad-spectrum and enhanced disease resistance to bacterial blight
 Molecular Breeding, 2012, 30(4): 1601-1610

3. Chang-Jin Park;Pamela C. Ronald

 Cleavage and nuclear localization of the rice XA21 immune receptor
 Nature Communications, 2012, 3(6): 920

4. Qiang Gan;Hui Bai;Xianfeng Zhao;Yong Tao;Haipan Zeng;Yuning Han;Wenyuan Song;Lihuang Zhu;Guozhen Liu

 Transcriptional Characteristics of Xa21-mediated Defense Responses in Rice
 Journal of Integrative Plant Biology, 2011, 53(4): 300-311

5. Fang Chen;Ming-Jun Gao;Yan-Song Miao;Yue-Xing Yuan;Mu-Yang Wang;Qun Li;Bi-Zeng Mao;Li-Wen Jiang;Zu-Hua He

 Plasma Membrane Localization and Potential Endocytosis of Constitutively Expressed XA21 Proteins in Transgenic Rice
 Molecular Plant, 2010, 3(5): 917-926

6. Chang-Jin Park;Sang-Won Lee;Mawsheng Chern;Rita Sharma;Patrick E. Canlas;Min-Young Song;Jong-Seong Jeon;Pamela C. Ronald

 Ectopic expression of rice Xa21 overcomes developmentally controlled resistance to Xanthomonas oryzae pv. oryzae
 Plant Science, 2010, 179(5): 466-471

7. Xuewei Chen;Mawsheng Chern;Patrick E. Canlas;Deling Ruan;Caiying Jiang;Pamela C. Ronald

 An ATPase promotes autophosphorylation of the pattern recognition receptor XA21 and inhibits XA21-mediated immunity
 Proc Natl Acad Sci USA, 2010, 107(17): 8029-8034

8. Sang-Won Lee;Sang-Wook Han;Malinee Sririyanum;Chang-Jin Park;Young-Su Seo;Pamela C. Ronald

 A Type I–Secreted, Sulfated Peptide Triggers XA21-Mediated Innate Immunity
 Science, 2009, 326(5954): 850-853

9. 白辉;李莉云;刘国振

 水稻抗白叶枯病基因Xa21的研究进展
 遗传, 2006, 28(6): 745-753

10. Marella Lalitha Shanti; M. L. C. George; C. M. Vera Cruz; M. A. Bernardo; R. J. Nelson; H. Leung; J. N. Reddy and R. Sridhar

 Identification of Resistance Genes Effective Against Rice Bacterial Blight Pathogen in Eastern India
 Phytopathology, 2001, 85(5): 506-512

11. Guo-Liang Wang;De-Ling Ruan;Wen-Yuan Song;Steve Sideris;LiLi Chen;Li-Ya Pi;Shiping Zhang;Zhen Zhang;Claude Fauquet;Brandon S. Gaut;Maureen C. Whalen;and Pamela C. Ronal

 Xa21D Encodes a Receptor-like Molecule with a Leucine-Rich Repeat Domain That Determines Race-Specific Recognition and Is Subject to Adaptive Evolution
 The Plant Cell, 1998, 10(5): 765-780

12. Wen-Yuan Song;Guo-Liang Wang;Li-Li Chen;Han-Suk Kim;Li-Ya Pi;Tom Holsten;J. Gardner;Bei Wang;Wen-Xue Zhai;Li-Huang Zhu;Claude Fauquet;Pamela Ronald

 A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21
 Science, 1995, 270(): 1804-1806

13. Pamela C. Ronald;Beng Albano;Rodante Tabien;Lleva Abenes;Kung-sheng Wu;Susan McCouch and Steven D. Tanksley

 Genetic and physical analysis of the rice bacterial blight disease resistance locus, Xa21
 Molecular and General Genetics, 1992, 236(1): 113-120

Structured Information

Gene Name	Os04g0504000
Description	Similar to Adenine phosphoribosyltransferase 2 (EC 2.4.2.7) (APRT)
Version	NM_001059779.1 GI:115459287 GeneID:4336327
Length	4794 bp
Definition	Oryza sativa Japonica Group Os04g0504000, complete gene.
Source	Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza. 1. 闫成业;刘艳;牟同敏 分子标记辅助选择聚合Xa7、Xa21和cry1C*基因改良杂交水稻金优207的白叶枯病和螟虫抗性 杂交水稻, 2013, 28(5): 52-59 2. Yanchang Luo;Jatinder S. Sangha;Shouhai Wang;Zefu Li;Jianbo Yang;Zhongchao Yin Marker-assisted breeding of Xa4, Xa21 and Xa27 in the restorer lines of hybrid rice for broad-spectrum and enhanced disease resistance to bacterial blight Molecular Breeding, 2012, 30(4): 1601-1610 3. Chang-Jin Park;Pamela C. Ronald Cleavage and nuclear localization of the rice XA21 immune receptor Nature Communications, 2012, 3(6): 920 4. Qiang Gan;Hui Bai;Xianfeng Zhao;Yong Tao;Haipan Zeng;Yuning Han;Wenyuan Song;Lihuang Zhu;Guozhen Liu Transcriptional Characteristics of Xa21-mediated Defense Responses in Rice Journal of Integrative Plant Biology, 2011, 53(4): 300-311 5. Fang Chen;Ming-Jun Gao;Yan-Song Miao;Yue-Xing Yuan;Mu-Yang Wang;Qun Li;Bi-Zeng Mao;Li-Wen Jiang;Zu-Hua He Plasma Membrane Localization and Potential Endocytosis of Constitutively Expressed XA21 Proteins in Transgenic Rice Molecular Plant, 2010, 3(5): 917-926 6. Chang-Jin Park;Sang-Won Lee;Mawsheng Chern;Rita Sharma;Patrick E. Canlas;Min-Young Song;Jong-Seong Jeon;Pamela C. Ronald Ectopic expression of rice Xa21 overcomes developmentally controlled resistance to Xanthomonas oryzae pv. oryzae Plant Science, 2010, 179(5): 466-471 7. Xuewei Chen;Mawsheng Chern;Patrick E. Canlas;Deling Ruan;Caiying Jiang;Pamela C. Ronald An ATPase promotes autophosphorylation of the pattern recognition receptor XA21 and inhibits XA21-mediated immunity Proc Natl Acad Sci USA, 2010, 107(17): 8029-8034 8. Sang-Won Lee;Sang-Wook Han;Malinee Sririyanum;Chang-Jin Park;Young-Su Seo;Pamela C. Ronald A Type I–Secreted, Sulfated Peptide Triggers XA21-Mediated Innate Immunity Science, 2009, 326(5954): 850-853 9. 白辉;李莉云;刘国振 水稻抗白叶枯病基因Xa21的研究进展 遗传, 2006, 28(6): 745-753 10. Marella Lalitha Shanti; M. L. C. George; C. M. Vera Cruz; M. A. Bernardo; R. J. Nelson; H. Leung; J. N. Reddy and R. Sridhar Identification of Resistance Genes Effective Against Rice Bacterial Blight Pathogen in Eastern India Phytopathology, 2001, 85(5): 506-512 11. Guo-Liang Wang;De-Ling Ruan;Wen-Yuan Song;Steve Sideris;LiLi Chen;Li-Ya Pi;Shiping Zhang;Zhen Zhang;Claude Fauquet;Brandon S. Gaut;Maureen C. Whalen;and Pamela C. Ronal Xa21D Encodes a Receptor-like Molecule with a Leucine-Rich Repeat Domain That Determines Race-Specific Recognition and Is Subject to Adaptive Evolution The Plant Cell, 1998, 10(5): 765-780 12. Wen-Yuan Song;Guo-Liang Wang;Li-Li Chen;Han-Suk Kim;Li-Ya Pi;Tom Holsten;J. Gardner;Bei Wang;Wen-Xue Zhai;Li-Huang Zhu;Claude Fauquet;Pamela Ronald A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21 Science, 1995, 270(): 1804-1806 13. Pamela C. Ronald;Beng Albano;Rodante Tabien;Lleva Abenes;Kung-sheng Wu;Susan McCouch and Steven D. Tanksley Genetic and physical analysis of the rice bacterial blight disease resistance locus, Xa21 Molecular and General Genetics, 1992, 236(1): 113-120
Chromosome	Chromosome 4
Location	Chromosome 4:25564488..25569281
Sequence Coding Region	25564611..25564779,25564904..25565014,25566857..25566949,25567372..25567521,25568371..25568429 ,25568526..25568582
Expression	GEO Profiles:Os04g0504000
Genome Context	<gbrowseImage1> name=NC_008397:25564488..25569281 source=RiceChromosome04 preset=GeneLocation </gbrowseImage1>
Gene Structure	<gbrowseImage2> name=NC_008397:25564488..25569281 source=RiceChromosome04 preset=GeneLocation </gbrowseImage2>
Coding Sequence	<cdnaseq>atgggggaagaggatatcagcaacgacagcaagagcagctgcggctgcgaggacggcacggtggaggctccggcggctgcggcgccgaaggagaacggccgagccgcggacccgcgcctccaggccatctccgacgccatccgcgtcgtcccgcacttccccaagccagggatcatgttcaacgacatcacggcgctgctgctccggcccgccgcgttcaaggacgccgtggacatgttcgtcgagcgctaccgcggcatgcgcatcgcggccgtcgcaggtattgaagccagaggattcatatttggcccagcgatcgcactagcaattggagcaaaattcataccgttgcgcaaacctaagaaactcccaggtgaggtaatttctgagacctatatacttgagtatgggacggattgtttggagatgcatgttggagctactgaacctggtgagcgcgtagtggtcgttgatgatttagttgcaaccggtggaacactttgtgctgcaataaaacttcttgaacgagctggagctgacgtagttgagtgtgcatgcctcattggccttcctaagtataagaatttctacaagctcaatggaaaaccagtttatatactggtggagtctcgcaaatag</cdnaseq>
Protein Sequence	<aaseq>MGEEDISNDSKSSCGCEDGTVEAPAAAAPKENGRAADPRLQAIS DAIRVVPHFPKPGIMFNDITALLLRPAAFKDAVDMFVERYRGMRIAAVAGIEARGFIF GPAIALAIGAKFIPLRKPKKLPGEVISETYILEYGTDCLEMHVGATEPGERVVVVDDL VATGGTLCAAIKLLERAGADVVECACLIGLPKYKNFYKLNGKPVYILVESRK</aaseq>
Gene Sequence	<dnaseqindica>124..292#417..527#2370..2462#2885..3034#3884..3942#4039..4095#gatagccggaggaagaagaagaagcaacagcagcagtcaagccaacccgtccggcgagcaagaagcaaccgaggcagcaaaaggaggaggagggaggactccactgttcgcttgtatcgtcttatgggggaagaggatatcagcaacgacagcaagagcagctgcggctgcgaggacggcacggtggaggctccggcggctgcggcgccgaaggagaacggccgagccgcggacccgcgcctccaggccatctccgacgccatccgcgtcgtcccgcacttccccaagccaggtccgccgcccgtactcactagctagctaagctcgatcgatcgatgtcgaaaccgttttaagaccacgccaaatcagttgaccacgtgaaaccaagtcacgcgcggctctacgttaatttgcagggatcatgttcaacgacatcacggcgctgctgctccggcccgccgcgttcaaggacgccgtggacatgttcgtcgagcgctaccgcggcatgcgcatcgcggccgtcgcaggtaaacactataaacagccgtacgtccaagcactctcccaaccaaaccggtcaaaccatgatcctttgcgcggcgcctttgccctcgcgtcgccatgtgccggcggcgcggcgcggcgccgagcctgacaccaacgccgacggcgacggccgagccgagctgtgggactgaggcggcggtgttgtgagattccgtaatatctttgggggagatctttcctgctccttttgtccccctacgctttgtcgtttgatcaggtcatcatcccagtcaccacctgcagcaattttttcccctctcacctcctcctactatttctcaatataaacaatttttgcgataattaaactccggcagcatcagcagcggccgtgcgggcgcaacagtggtggtggtagaccggtaggtgcatgcgctgctgaactgtgacaactgtcgatacacgcacgtatgtcgaacataggagtactatactagtgtatcataggagtatgtctttctcgccgtctggtccagaggggcaataaatgcaggggccaatgcctccacgggccacggctgtggatggagcagccgcaggaaaggcgccgcgccgaggcggagaggagaatgccgatgcctccctgcaccgcacgctacgtactacgtgcgccgcgggcgcgggcgcatgtgggggatgtgcgtgtgcatccgtccgtccgtccgtgcgcgcgtggcgcgtagtagcgcggtggtactgtatggtccacggctgcgcgctccgaggcgccgatccgcgtgcgtgcgtgcggccagaatgtacgtacgcctcgtcgcgtcgcgtcgagcgagcgctcgctggttggctggcgcggctgcggctggctggctccgccgctcgcggggctccgctggggccagcggaatcttgggcgattcaatgcgcggatcggagccatgtacacggccggtgattgggtgggacgagagaaacaacaaacaacgagagatcgatcgatcgatcaacgcacggagagtcggagaggtcgcgattccttcctatgacacgctcggtggtagcaggctgggcagcggggagtcagttcggtctcttccctcggctgcgttgtggtgtggggtgagcggggaccggcccccagccgctctgtgggccggggatcccctccctcatcggacggccatgattgcgcacatgcggtgtcggaggtctcgctctctcccgtgtagtgtcgtcatctttggaacaatcacatgatggtttccgtttggttttgattctatgcagtgcaaactgagctcgctttcgctcagtgcatgtactgcacgacctcacgtttttcgttctagatgcaaaccggccgcgagtacaatgatctgatttttttagattgggagttggagtacagagtctgattagcttttcccggccgtgtgtgtttgctcgaagcactttactttcacggcattatggcgtttgttgtgacataaacctccaataattgaatagccatcgcaacgtcatcgtatttatactggctagttgaaagtttttactcctacaaggctacaatgaacatcgaacactgtgttgcaaaagtacatatggaagttctatcagggacgtttgctagtgatggatactttaaaattgtagatttctagtagtaaatttggtgggaaaaactgtagttctacgaaaaatttgatgttaaacatataactttgggatcttacatcttaaatttatagttttgtcaaatatgtgtgttttgtgaattttactgttataaatctaatttccatgtgtatatatatatggtgaaattctccaacttatgctaggtattgaagccagaggattcatatttggcccagcgatcgcactagcaattggagcaaaattcataccgttgcgcaaacctaagaaactcccaggtgaactacggactatgtcatttcgctcatacaaggagcatacctacatcctaaaacataaggaattttacccatatagtttacatgagtaaaatcccttatattttaggatgaatgtattaatttgtttactcgcacacagtacatttgcttccactgaaaatgctgtagcaacattatatatgtactactgctactactcatagaacctgttagcacatgaaccactcatcatgtcagctactgaaatagttatagcttgagtacactcaataaatgttgtttgaggatcattgaaatggtctgatgaatagaactgtagattttattccgctttggtactggtatacagctatatactacaaactcaatatagagttgctagtagaatgtgctaacagtggcttttacaaatcttaaaggtgaggtaatttctgagacctatatacttgagtatgggacggattgtttggagatgcatgttggagctactgaacctggtgagcgcgtagtggtcgttgatgatttagttgcaaccggtggaacactttgtgctgcaataaaacttcttggtgagtaactaaccgtttgtctcctcagcatgtatgcaaatgtaattcattgactgtggacaacactaaacaagtacgtacgtaagtgttaaaaaaatactattgttattttcagtttgctatgctctataatgctacttctaggtgacttatcatatgttttaacttctcaagtctgtcgaataataaaacacacattttaagctgaaaatttggttttcctgaacagataagcaatagaggaccttgagttatttaggatatttgctgactgttgtggaaaggatattctgatattttcttgtgataataacaaacattatattctgacttcaaaatgattcatattaaacgaaaatatcttaaatacatagtgccggacaaagaaagtgagagaaagtggaagaaaatggagtactgaatgtgtatatcatgtactactaatttagtaaaacatacaggacgtgaagctgaatatcatggatcatagtggagaagatcatgtaacattgtcaagcatcaaacagctcagtgataatatgtagagtagaggggcatcatgttctgttgaccttaagaaaagtatgctccccagtgagtcaacgggacaaactgtttattcatgggacaaaatcctgtccggaagatatgtcctattgggtggctaatcacctacatgcatgataagactggaggcataattttgatcttatcttacaaccgaaaagttcgtggataagaatcgagcattcaagaccctcccttttctctttttatgacactaaaacaactaactattctagtgtttacatctgtttatgcttattgctcaaactatttgcattccagaacgagctggagctgacgtagttgagtgtgcatgcctcattggccttcctaagtataaggtacactcatattttggttaagaaaattgagaatcgcatctcacttttaataccttgatcaattatttgcttactggacttgcatgttttatacagaatttctacaagctcaatggaaaaccagtttatatactggtggagtctcgcaaatagaaagtaacaaagcaatgatcaggcaagcatcacttttatgcttgaaattttctccaatatctccttttattttgataataatgtttgtaccatgttgtgcaatacagctaggctgcattattgtttgttcatggtcttttatcaatgcactgcttccatacacagtcgacatgagggtttaaaatgatgtgtactgttcttgacaagagtacacatgttgttaggtcctgacaattggtttataaaactttaaaatttctggatttttttatccgggtcagtgaaatattaatattgaaacgaggggcaaattgtgaatattgagcttctaattcatgtttccccctcctatcctttttcagaaagattcacagcttcattcctttgcaagagcacgttggaggaattggatcggtattggtgagcagtgactctgcacgcagcacaactgttaatgtaatctcggtggagagatgatgagatagatgaaatgtaatctttgtagcacgactagttttccaggtagtgtcgacgacgagagcttgtagttatttctgtcgggaactgttgattacccggaagagaaagggattaagggaattgccatcccgcttgttcagttcctcttttcttttctagtgacaattgtccttttcgccgcacttgatgatttatacttctttggtaaaactaccactc</dnaseqindica>
External Link(s)	NCBI Gene:Os04g0504000, RefSeq:Os04g0504000