Os02g0100200

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Annotated Information

Function

Steroid receptors of the nuclear receptor family are all transcription factors. Depending upon the type of receptor, they are either located in the cytosol and move to the cell nucleus upon activation, or remain in the nucleus waiting for the steroid hormone to enter and activate them. This uptake into the nucleus is facilitated by nuclear localization signal (NLS) found in the hinge region of the receptor. This region of the receptor is covered up by heat shock proteins (HSPs) which bind the receptor until the hormone is present. Upon binding by the hormone the receptor undergoes a conformational change releasing the HSP, and the receptor together with the bound hormone enter the nucleus to act upon transcription.

Expression

Genomic Depending on their mechanism of action and subcellular distribution, nuclear receptors may be classified into at least two classes.[5][6] Nuclear receptors that bind steroid hormones are all classified as type I receptors. Only type I receptors have a heat shock protein (HSP) associated with the inactive receptor that will be released when the receptor interacts with the ligand. Type I receptors may be found in homodimer or heterodimer forms. Type II nuclear receptors have no HSP, and in contrast to the classical type I receptor are located in the cell nucleus.

Free (that is, unbound) steroids enter the cell cytoplasm and interact with their receptor. In this process heat shock protein is dissociated, and the activated receptor-ligand complex is translocated into the nucleus.

After binding to the ligand (steroid hormone), steroid receptors often form dimers. In the nucleus, the complex acts as a transcription factor, augmenting or suppressing transcription particular genes by its action on DNA.

Type II receptors are located in the nucleus. Thus, their ligands pass through the cell membrane and cytoplasm and enter the nucleus where they activate the receptor without release of HSP. The activated receptor interacts with the hormone response element and the transcription process is initiated as with type I receptors.

Non-genomic The cell membrane aldosterone receptor has shown to increase the activity of the basolateral Na/K ATPase, ENaC sodium channels and ROMK potassium channels of the principal cell in the distal tubule and cortical collecting duct of nephrons (as well as in the large bowel and possibly in sweat glands).

There is some evidence that certain steroid hormone receptors can extend through lipid bilayer membranes at the surface of cells and might be able to interact with hormones that remain outside of cells.[7]

Steroid hormone receptors can also function outside of the nucleus and couple to cytoplasmic signal transduction proteins such as PI3k and Akt kinase.[8]

Evolution

Nuclear receptors Subfamily 3: Estrogen Receptor-like Group A: Estrogen receptor (Sex hormones: Estrogen) 1: Estrogen receptor-α (ERα; NR3A1, ESR1) 2: Estrogen receptor-β (ERβ; NR3A2, ESR2) Group B: Estrogen related receptor 1: Estrogen-related receptor-α (ERRα; NR3B1, ESRRA) 2: Estrogen-related receptor-β (ERRβ; NR3B2, ESRRB) 3: Estrogen-related receptor-γ (ERRγ; NR3B3, ESRRG) Group C: 3-Ketosteroid receptors 1: Glucocorticoid receptor (GR; NR3C1) (Cortisol) 2: Mineralocorticoid receptor (MR; NR3C2) (Aldosterone) 3: Progesterone receptor (PR; NR3C3, PGR) (Sex hormones: Progesterone) 4: Androgen receptor (AR; NR3C4, AR) (Sex hormones: Testosterone)

Labs working on this gene

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References

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Structured Information

Gene Name	Os02g0100200
Description	Steroid nuclear receptor, ligand-binding domain containing protein
Version	NM_001052115.1 GI:115443600 GeneID:4327972
Length	4599 bp
Definition	Oryza sativa Japonica Group Os02g0100200, complete gene.
Source	Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza.
Chromosome	Chromosome 2
Location	Chromosome 2:9298..13896
Sequence Coding Region	9542..9762,11085..11196,11328..12749,12830..13624
Expression	GEO Profiles:Os02g0100200
Genome Context	<gbrowseImage1> name=NC_008395:9298..13896 source=RiceChromosome02 preset=GeneLocation </gbrowseImage1>
Gene Structure	<gbrowseImage2> name=NC_008395:9298..13896 source=RiceChromosome02 preset=GeneLocation </gbrowseImage2>
Coding Sequence	<cdnaseq>atgaggaagcgcactgcatctgatcgcattcgggtcccctccagcaaccccgcgccatcgccgtcgccgccgccgccgccgccgccgccggaggaacctgccgtgcccatgccgcatgttggggcccgccgctccacgcgcgtcttcgtgcccaagacgcccaggccgcctcagccttctgatcctgccagggtcctccgctccggcaagcgcctcgccttctccgaatcccccgccgacgcccactggttccagtgcaagcccaacaactgcttccacgtccatgaccaccaacgccaacttcacgacgaccccaagccaccgccgccgcctctgccgcgcacaaggtccttcgggatcgtctacagcaggaagcgccgccgccgcctccccgaacccaaggaggacaccaggtttgccattgtcttcactaggaagagacccaaggtcgccccttttcagcaccacgccccgaacgaccttgccaccatcccatgctcctcttccagggagtttgcctccaggactggcttctttgattcccatttcttgaccctggtggattgtattcccactaataaagctgacgctgccatgcttattgtccttgtggattcatcttgctctgggagctctcagcacttcttgcgcctcctcctctctgtgctgcgctggatgcgtagctgccgacggggcaaggtccgaaaccttgcctcctttctctcgtccgatgctgtcgccactgcgcttgcattgcggggattgcattttgtccagcttcaatgccggagagactgtgcattgtcacagagggctttggtgcaatgtggctggtgtgagcttcgtggtgccaaggattctgaaccattgttgtctgtcaatttcttggcagtcccttcttacttccagattttgcacttgttaatagcactcgagtcaatgtatcttccagctgtgattcgtacgagaatgcatttggttggtggagctgaagaaatttatcctcgcaccctattggaggaggattctgaatctctgagcactggggatactgatcctgctgttgacctgtgtagcaacaaactttgcagtgtggctcaagattatgtgccccttgaagagattgcaggagtggtggtccatggtctgaggctaaagaagcatcaaaggaagagaagctctatgcggcatcccctcagtcgacagcgtcttgctgcaagatttcccgacaaggtagttgcaacaaaccagaccgatgtggctagacagacagaagcggatgcgccaccctcagttagtccggagcttccactggagcctgtcaaacctaaagcagcactggaaatctctcttgatttgcttgaaaacatggatgacagtgatgtttcaactcctataggatcaaatgggaagcaaaagaggtcttctttgaaaagtcccattgagcgcatgaatgaaaggttggctttggctgaggttagacagaatatagattctgttcactgcagagcaaaccttttaattattcaacctgataggtgctggagggaagaaggcgctgaagttatgctggaaccatcggaatcaaatgagtggtgtatagctgtgaagatacatggtgtcaatagaatatctctgaagccttcggagcagaggttttatgttgttaaccggttcacccatgcctatattttggcagttgatgatggattgaagattgagttctctgataaatgggactggcttttgtttaaggagttgcaaattgagggtcgggagcgcaattcccagggaaagatgataccaattcctggtgtaaatgaggtttctgatgacatgggagtgattggaacatatcctttttcacgccctgtgccagactatatcagaatggcggatgatgaggttgggcgagctctctcaagggactctgtatatgatctggattctgaggatgaacagtggctcacccagttgaatcattcagattctgacagaaaaagcgcacatcttaatcatatttcttatgaagattttgaaaagatgattaccacgtttgaaaaggatgctttcaacaaccctgaaggaactagtgatttggatcagattctttccagataccctactttggaaaaggaccataatgtccttgctgtgcatgaatattggataaacaagagatataagaaaggtgtaccactgctaaggatattgcagggtgcaacactaagacgaggacaactgtcacaaagatctattaagaaaaaaagatctttcaagagacaaagaagccaagctggccgtggaaagcctgacatatgcttgcaagatgctaatggtgctgaagaggaggctttgcggagagttgtggaagccgaacgtgctgcaacacaggcaggagaaacagctgttcgtctgcgcagtagagctcagcgtctcatggcaaaggctgagctggtggcatacaaatctattatggccctcaggattgctgaggctgctaggatatctgactcgtcacgggatcttgttttgacgaccctcgactag</cdnaseq>
Protein Sequence	<aaseq>MRKRTASDRIRVPSSNPAPSPSPPPPPPPPEEPAVPMPHVGARR STRVFVPKTPRPPQPSDPARVLRSGKRLAFSESPADAHWFQCKPNNCFHVHDHQRQLH DDPKPPPPPLPRTRSFGIVYSRKRRRRLPEPKEDTRFAIVFTRKRPKVAPFQHHAPND LATIPCSSSREFASRTGFFDSHFLTLVDCIPTNKADAAMLIVLVDSSCSGSSQHFLRL LLSVLRWMRSCRRGKVRNLASFLSSDAVATALALRGLHFVQLQCRRDCALSQRALVQC GWCELRGAKDSEPLLSVNFLAVPSYFQILHLLIALESMYLPAVIRTRMHLVGGAEEIY PRTLLEEDSESLSTGDTDPAVDLCSNKLCSVAQDYVPLEEIAGVVVHGLRLKKHQRKR SSMRHPLSRQRLAARFPDKVVATNQTDVARQTEADAPPSVSPELPLEPVKPKAALEIS LDLLENMDDSDVSTPIGSNGKQKRSSLKSPIERMNERLALAEVRQNIDSVHCRANLLI IQPDRCWREEGAEVMLEPSESNEWCIAVKIHGVNRISLKPSEQRFYVVNRFTHAYILA VDDGLKIEFSDKWDWLLFKELQIEGRERNSQGKMIPIPGVNEVSDDMGVIGTYPFSRP VPDYIRMADDEVGRALSRDSVYDLDSEDEQWLTQLNHSDSDRKSAHLNHISYEDFEKM ITTFEKDAFNNPEGTSDLDQILSRYPTLEKDHNVLAVHEYWINKRYKKGVPLLRILQG ATLRRGQLSQRSIKKKRSFKRQRSQAGRGKPDICLQDANGAEEEALRRVVEAERAATQ AGETAVRLRSRAQRLMAKAELVAYKSIMALRIAEAARISDSSRDLVLTTLD</aaseq>
Gene Sequence	<dnaseqindica>4135..4355#2701..2812#1148..2569#273..1067#acccgcaaccccaacggaggaggaagggaagaagggaggaaaccctaaaattcctcttctccttctgctctcgattcgattcgatctcgtcgccacgcccccgcccccgcccccgccccgccccgcaagccgccgatctgttgcgcctcgtcaagaccccccagcccaagatctgattcgtttcgattccgagctgagcagcagcaggagcaggaggaggaggaggagctcatcgatttggtggttgctgatgggcggcgcatccatgttggatgaggaagcgcactgcatctgatcgcattcgggtcccctccagcaaccccgcgccatcgccgtcgccgccgccgccgccgccgccgccggaggaacctgccgtgcccatgccgcatgttggggcccgccgctccacgcgcgtcttcgtgcccaagacgcccaggccgcctcagccttctgatcctgccagggtcctccgctccggcaagcgcctcgccttctccgaatcccccgccgacgcccactggttccagtgcaagcccaacaactgcttccacgtccatgaccaccaacgccaacttcacgacgaccccaagccaccgccgccgcctctgccgcgcacaaggtccttcgggatcgtctacagcaggaagcgccgccgccgcctccccgaacccaaggaggacaccaggtttgccattgtcttcactaggaagagacccaaggtcgccccttttcagcaccacgccccgaacgaccttgccaccatcccatgctcctcttccagggagtttgcctccaggactggcttctttgattcccatttcttgaccctggtggattgtattcccactaataaagctgacgctgccatgcttattgtccttgtggattcatcttgctctgggagctctcagcacttcttgcgcctcctcctctctgtgctgcgctggatgcgtagctgccgacggggcaaggtccgaaaccttgcctcctttctctcgtccgatgctgtcgccactgcgcttgcattgcggggattgcattttgtccagcttcaatgccggagagacgtaagccttctacagacttaaaaagtgtgccagttttagttccttgtacacctggttaatgtgtatgccttttcttgcagtgtgcattgtcacagagggctttggtgcaatgtggctggtgtgagcttcgtggtgccaaggattctgaaccattgttgtctgtcaatttcttggcagtcccttcttacttccagattttgcacttgttaatagcactcgagtcaatgtatcttccagctgtgattcgtacgagaatgcatttggttggtggagctgaagaaatttatcctcgcaccctattggaggaggattctgaatctctgagcactggggatactgatcctgctgttgacctgtgtagcaacaaactttgcagtgtggctcaagattatgtgccccttgaagagattgcaggagtggtggtccatggtctgaggctaaagaagcatcaaaggaagagaagctctatgcggcatcccctcagtcgacagcgtcttgctgcaagatttcccgacaaggtagttgcaacaaaccagaccgatgtggctagacagacagaagcggatgcgccaccctcagttagtccggagcttccactggagcctgtcaaacctaaagcagcactggaaatctctcttgatttgcttgaaaacatggatgacagtgatgtttcaactcctataggatcaaatgggaagcaaaagaggtcttctttgaaaagtcccattgagcgcatgaatgaaaggttggctttggctgaggttagacagaatatagattctgttcactgcagagcaaaccttttaattattcaacctgataggtgctggagggaagaaggcgctgaagttatgctggaaccatcggaatcaaatgagtggtgtatagctgtgaagatacatggtgtcaatagaatatctctgaagccttcggagcagaggttttatgttgttaaccggttcacccatgcctatattttggcagttgatgatggattgaagattgagttctctgataaatgggactggcttttgtttaaggagttgcaaattgagggtcgggagcgcaattcccagggaaagatgataccaattcctggtgtaaatgaggtttctgatgacatgggagtgattggaacatatcctttttcacgccctgtgccagactatatcagaatggcggatgatgaggttgggcgagctctctcaagggactctgtatatgatctggattctgaggatgaacagtggctcacccagttgaatcattcagattctgacagaaaaagcgcacatcttaatcatatttcttatgaagattttgaaaagatgattaccacgtttgaaaaggatgctttcaacaaccctgaaggaactagtgatttggatcagattctttccagataccctactttggaaaaggaccataatgtccttgctgtgcatgaatattggataaacaagagatataagaaaggtgtaccactgctaaggatattgcaggtattttttgactttatcccttccccaaatattaatacaaagctggaaccttcacaaagattaccctctattgtctgcatatcctgaacttctggttatattttctaaatgttaaccttcttgatcattagggtgcaacactaagacgaggacaactgtcacaaagatctattaagaaaaaaagatctttcaagagacaaagaagccaagctggccgtggaaagcctgacatatgcttgcaaggtactgatgttttctccttgatgtctatcttactagagaattgggaccgccattggcgtggcccttcacttagttgaagcaagaaagcatcataaaagatacaagaagcttctttatccatttgtccgaagagtgacctcaattgatttcggaagccatgtgaatctttttttctttcacataagaaaccacatccttctatgcctgaaatatcaagcactcctaatattatatctaatcctacattttagcatctgtaaggttacagtgttagtttccctgcctctggtgtattaccaattttccatatcaaggtgcacaaagttgctaagtagatggccatggtattttagctacattcgatccagttggaaatagttgggtgtaaacatgtgtatatataattactttgataagaatggttacagaaaaatgcatgcataatttgtagtaatcggcaaactaacaaatctattggaaatgataacttctcactccatcccaaaatttatccagaagttgctatattttggggaggaggtggtaataaatttctacttgccacccttagtagatactacacagttaataaaatagcactaattgtggcatatataaatatgaaccttggatataacgtagaatacttgttgtgtaatgttatgtaaggaactctactaaaatatgaagcatgttatatgttctatcatatttttggtgaatgaaccactagtaattttgggcctatgtattcacaaacgaaacaactctcctatgaggcctaacaatagaatgcttgctccttgtgaggagagagtcctcggtgaattactttgggacaggttacagttagctattcagccagtgtctcaaacccttaataaatgctaatgtttagggcaaatagcacttatcatcaaaactatgattcagatgagatccatcatcgcagcttgtcgccaagaccaccttgttcacttgtagctttttcatccttttccaataatagttgcagatttattcttcaccttgtccctctcatctgctaggtgattcaactcctgtagcagcagatctgtgcaatcctagttcacaaacaatacaaactgcaaaacaatccagatcatgcttgatgaaagcatgctccctgtaattatgaagaaactaattactagtaacatttatgaccattgttccactggtacatgcatgcaagtttgtgtaccataacgtagcgtttttttatcccgatgttgcagactaagttcctactgaggggaaataatcttgtgttgtcttttactcgacatgttgatggacagatgctaatggtgctgaagaggaggctttgcggagagttgtggaagccgaacgtgctgcaacacaggcaggagaaacagctgttcgtctgcgcagtagagctcagcgtctcatggcaaaggctgagctggtggcatacaaatctattatggccctcaggattgctgaggctgctaggatatctgactcgtcacgggatcttgttttgacgaccctcgactagtgaagaatgtgagtgagatgttcattgatttgtgtgaagagcatagtagccaatagtttgttttcctcttttttgccgcatcatttcaatgctacgtggtatttggctttcgggtaagctgtgggctgtgggtctcttttttcctccccacctgttttaactttgtgaagccaatctttgtagcggatgcttgaactcaactgtaatctcttgtgtacatgatagtggttagttagattgtgtg</dnaseqindica>
External Link(s)	NCBI Gene:Os02g0100200, RefSeq:Os02g0100200