Os01g0103600
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Contents
Annotated Information
Function
The emopamil-binding protein(EBP) acts as a high affinity acceptor for several antiischemic drugs and thus represents a potential common molecular target for antiischemic drug action. Degenerate oligonucleotides were synthesized according to the N-terminal amino acid sequence of purified EBP and used to amplify a guinea pig cDNA with reverse transcriptase-polymerase chain reaction and to clone full-length cDNAs from guinea pig and human liver cDNA libraries. The phenylalkylamine Ca antagonist emopamil labels a high affinity binding protein (emopamil-binding protein, EBP) for a variety of structurally different compounds in guinea pig liver. Some of these drugs such as emopamil, ifenprodil, opipramol, trifluoperazine, and chlorpromazine exert antiischemic effects in animal models of stroke, but their neuroprotective action is not fully understood at the molecular level. Since the possibility exists that EBP is involved in ischemia-related cellular events biochemical studies were undertaken to investigate the physiological function of EBP.
Expression
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Evolution
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Labs working on this gene
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References
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Structured Information
| Gene Name |
Os01g0103600 |
|---|---|
| Description |
Emopamil-binding family protein |
| Version |
NM_001048292.1 GI:115433997 GeneID:4326449 |
| Length |
4013 bp |
| Definition |
Oryza sativa Japonica Group Os01g0103600, complete gene. |
| Source |
Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
clade; Ehrhartoideae; Oryzeae; Oryza.
|
| Chromosome | |
| Location |
Chromosome 1:185250..189262 |
| Sequence Coding Region |
185516..185771,188607..188715,188841..188990,189087..189231 |
| Expression | |
| Genome Context |
<gbrowseImage1> name=NC_008394:185250..189262 source=RiceChromosome01 preset=GeneLocation </gbrowseImage1> |
| Gene Structure |
<gbrowseImage2> name=NC_008394:185250..189262 source=RiceChromosome01 preset=GeneLocation </gbrowseImage2> |
| Coding Sequence |
<cdnaseq>atggggcacccccacccccacccttacgcgccggcggagcttcacctcccgggcttcgtgcctctccaactgtcccaggcccaaatcctcgtgccctacctcgccacctccctcttcctcctcctcgccgtctggctcatctccgggagatgcagtcgtaggctttccgacaccgaccgctggctcatgtgctggtgggccttcaccggcctcacccacattatcatcgagggaacctttgtctttgctcctaatttcttctccaaccaaaacccttcttacttcgatgaagtttggaaagagtacagcaaaggtgactccagatatgtcgccagagaccctgctactgttacagttgaaggaattacagctgtcttggaaggccctgcttcactccttgctgtctatgccatcgcatcgggcaagtcctacagccatatcctccagttcactgtctgtcttggtcagctctatggatgcctggtgtactttattacagcctacttggatggcttcaacttctggactagcccgttctacttctgggcttatttcattggtgcaaacagctcgtgggttgttataccaactatgatcgccataaggagctggaagaagatttgtgcagcatttcaaggtgaaaaggtgaagactaaatag</cdnaseq> |
| Protein Sequence |
<aaseq>MGHPHPHPYAPAELHLPGFVPLQLSQAQILVPYLATSLFLLLAV WLISGRCSRRLSDTDRWLMCWWAFTGLTHIIIEGTFVFAPNFFSNQNPSYFDEVWKEY SKGDSRYVARDPATVTVEGITAVLEGPASLLAVYAIASGKSYSHILQFTVCLGQLYGC LVYFITAYLDGFNFWTSPFYFWAYFIGANSSWVVIPTMIAIRSWKKICAAFQGEKVKT K</aaseq> |
| Gene Sequence |
<dnaseqindica>3492..3747#548..656#273..422#32..176#ctctccagtccagatcggaaggaagccaggaatggggcacccccacccccacccttacgcgccggcggagcttcacctcccgggcttcgtgcctctccaactgtcccaggcccaaatcctcgtgccctacctcgccacctccctcttcctcctcctcgccgtctggctcatctccggtattcctttcttccttccttctcctctcggctcgctaaattccaacatctctttgctcaatcttctttgcttccatttgctttgctttgctgcagggagatgcagtcgtaggctttccgacaccgaccgctggctcatgtgctggtgggccttcaccggcctcacccacattatcatcgagggaacctttgtctttgctcctaatttcttctccaaccaaaacccttcttacttcgatgaagtttgtaagcctccttttcttttctaactccactatcattcatctcccttctatttactattatcttattggattattacgcactagctactaacaataatcaccatcctcctttcctttcctttccagggaaagagtacagcaaaggtgactccagatatgtcgccagagaccctgctactgttacagttgaaggaattacagctgtcttggaaggccctgcttcactccttgctgtgtactcatcttttcttccatttcacctcaccatgcgcaccttacctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctcttttccatttcttacatatttaacgatcttctcattacaaatgcatttttcacatgtttttctacctttcgttatactattgtttttctttcctctttcgagttaaccttttgctagccaatctagttattccggagcatcaccttctgaattaacatgtactagccaattaagtcgcctgtttgtgcgaccatgagtaattcacctatgatcacattttccctatctcatattgtaatattattatcttttttgtacaacaaaccgtagccctttgattataacactgaatctagcttgcccaaagttgtactctctggcttccaagttaccgaaaatggaactgaaaattatactctctggcttccaaatggatataagtgaaaacgactgaaaatttgttcgcatacagagctgactttaaattcatatcataagcggaaatggaataataggcaatggaaaagtattttggtgccaaacagattaaattctgtgttttggacttgtaattagtaaaggaaggcaacagccatgattagaagggaattgtggaaatagtatttacagcccaaatactcctatctaaatgcaactcaatctggaattagaaaaaaaaatatgttggcaagctaggctcatattagaacttcatgagctgacgtgcttgtccaggaaagtgttttcaagattactaaagctggtattagcatatccaaccgcagcatactgttttactgccctaagtacatcttgtttcagtgtctttctttgttgaaggtttccagaaatcatacaaagccacatgtgcatatagttctgcatatagttctcctgtcgtgtactaattgaaaatgagttactttcataggaaaaaaaactggggaatcgataataaagaactaaaactcctttcagcaaatatatgcaaaattgaattccaccaaaccaagtattaactgaagcatttgctggatctgcatatatgcaaacaaaacattaaggcttaaataggaactttgtttgctggaaacagaaagagatggtaaatcgaaaggaaagttagaatcattaacagagcataaaaaatatagtcaagccaaaacgaatcatgcctcctatctaagcccccatggactcaaccttaatttatgaacttctataattcagtcatagttttgcagtaaattcagtcatcttgctgtacttctttccaattcatccctataggtcaacatctcaattgacagttgcatattcattccaaattgttcagtcacagtgagtcaccatatccctataggtcaacatcttacttggacagttgcatattcattccaaattgttcagtcaccgtgagtcaattgagcaactttttactgtaacacattgaaggaggcagcactaaccttgcaatgaagtcatgtgcttatgacctcacagggtctctatctcatgagctgatggtaccgtaacgggcatgccattttgctatttgctcatttcaatctaaactggaaagaagcaattttttattggcatccacgattccaggggtgtctccctgccgctgccaccttctccactcccatacctgatgcgtgggagcaggcaaaagtgcagggatagggaggaagaagtggaagatggcggcgtcgcatcatcccactctgttgctcccagaggaaaattgttgagctgctcagccagtgaaagaggatgcatgtggtacctcagcctcgccgccacccatcttcaccgtcggtatggtttggatccagcgattcctgagcttgcggtggcttgcccccgagctcagtgcggggtgcttgaatctgatgaggaacgcggtgcggcctggatggagcggcggcctcgatttggccacggtggggatgaggagccaacttcggaggcggtgggggataggaggaagatgcggcagctgggatgacgagggggtttggagtggaggcggtggtgtggcgcagcacgcaaaggagaggaggggtcgtgctttggtagatggggagggaggagggggtaaatataaaagaatcgattctaagggtatggaaggatctagttttggtataagtttcatgaaggatgtttatgttctttatccatttggggaatctgatggttcttattggctcatgaaaatatcgaatggttgaagttttgttgatgacgtggatgcgttaactttgcaagaaaggattcatctttcatttatttagatgtatctgcatccatcatacatgctccaagtgaatgcattttttttacatcatgccaatcgcatgttgcatttgccacaagacataaatcgtcgtggacagcagaatccaatgttcatgggctttatggagtagcttttcttgtcttcaactaaacaatcctgattgattgatgattggactggatcctcataagggaagtagcggtgctataggaattgtatgtgtttgatgcctataaaatctatccacagaatatttgtgttctcctttttgttagtttacacattggattgacctgtctgcaagcgtcaatatcaatatgtaactggttattaagccagactattcactattgtacatcctgcattccatgtactagttgataggagtttcttttgccccctagacagttgatatgagtataatatagccttttgtggtttatagtttccacctgacctgacaaaaagtttgctgcttgcagctatgccatcgcatcgggcaagtcctacagccatatcctccagttcactgtctgtcttggtcagctctatggatgcctggtgtactttattacagcctacttggatggcttcaacttctggactagcccgttctacttctgggcttatttcattggtgcaaacagctcgtgggttgttataccaactatgatcgccataaggagctggaagaagatttgtgcagcatttcaaggtgaaaaggtgaagactaaataggcaaagggtgcaccttagtcacagtttggttggaaattaatagacatttgtgctatgaacaacatcattgttcctgcaattgaaacccttgtgttactgaaaaattgcattgtacccttggagggaacatcagtgttaattggatgtgactttatgcagctattatgtattgctgcaaaagaaattgggttttgtttatcctctatcattcaagctcgctcttctttacccttgaagaaataaaagggcagggagttgccattttg</dnaseqindica> |
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