Os04g0447800

Glutamate decarboxylase (GAD) converts L-glutamate to g-aminobutyric acid (GABA), which is a non-protein amino acid present in all organisms. Plant GADs carry a C-terminal extension that binds to Ca2+/calmodulin(CaM) to modulate enzyme activity.

Annotated Information

Function

Plant GADs carry a C-terminal extension that binds to Ca2+/calmodulin(CaM) to modulate enzyme activity.Glutamate decarboxylase (GAD) is an enzyme that catalyses the conversion of L-glutamate to c-aminobutyric acid (GABA), which is a non-protein amino acid that is commonly present in both prokaryotes and eukaryotes. In animals, GABA is known to be a major inhibitory neurotransmitter.

Expression

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Evolution

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Labs working on this gene

• Department of Biological Science, Shimane University, Nishikawatsu 1060, Matsue, Shimane 690-8504, Japan
• Transgenic Crop Research and Development Center, National Institute of Agrobiological Sciences,Kannondai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan

References

• Akama K, Akihiro T, Kitagawa M, Takaiwa F. 2001. Rice(Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochimica et Biophysica Acta 1522, 143–150.