BGIOSGA000971
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Annotated Information
Function
Please input function information here.Multidrug and Toxic compound Extrusion proteins (MATE) are a family of secondary active transporters which utilize electrochemical gradient of membrane maintained by ATPases for their transport activity. Members of this transporter family have ubiquitous occurrence in all the organisms including human and plants. The first member of this family (NorM) was characterized from Vibriopara haemolyticus, which effluxes nofloxacin and ciprofloxacin outside of the cells in an energy dependent way. Most of the earlier studies suggest that MATE proteins act as an efflux pump that export majority of drugs and xenobiotic compounds outside the cell, and largely contribute to the drug resistance in bacteria. Recent reports indicate that MATE proteins function in antiport manner and drive the substrate transport in exchange with H+/Na+ depending on the organism. Studies suggest that H+ coupling is operational in plants, which is substituted by Na+ in bacteria. Though structure and mechanism of action of MATEs have not been studied in detail, recent investigations revealed conformation and transport behaviour of MATE proteins. Conversely to designated name “multidrug”, numerous studies revealed that MATE proteins have stringent substrate specificity and facilitate the movement of specific compounds. Presence of homologous putative MATEs has been identified from several organisms through comparative genomics. A genome wide scanning and analysis revealed that 58 MATE paralogues are present in Arabidopsis genome. In general, MATE proteins from various source organisms have a conserved domain and share at least 40% amino acid sequence homology. In higher plants, studies demonstrated that MATE proteins are mainly involved in the transport and trafficking of xenobiotic and small organic molecules. The foremost characterized Arabidopsis MATE protein, AtDTX1, was demonstrated to export norfloxacin due to its ability to restore drug tolerance in the norfloxacin sensitive bacterial mutant (kam3 mutant). Recently, evidences for role of MATEs in the plants are rapidly accumulating. Depending on the established functions of this gene family in plants, MATEs have been grouped into three major classes. The first group of the MATE has been demonstrated to be associated with disease resistance in Arabidopsis. Several Arabidopsis mutants have been identified and examined for understanding the molecular mechanism of pathogen resistance. Among them, enhanced disease susceptibility mutant (eds5) of Arabidopsis displayed a reduced basal resistance during pathogen interaction. The fine genetic mapping of the eds5 locus identified that EDS5, a member of the MATE transporter family, was localised within this locus, and substantially contributed to disease tolerance. The relation of EDS5 with disease tolerance has been explored very recently and demonstrated that EDS5 export salicylic acid (SA) outside chloroplast, where SA synthesis takes place. Similarly, ADS1 (activated disease susceptability1), a negative regulator for the disease resistance, was another MATE identified in Arabidopsis showing involvement during pathogen infection. A second group of MATE proteins is known for exporting small organic molecules such as citrate outside the cell which acts as a ligand molecule to bind aluminium (Al) in the rhizosphere. Unlike to other metals, Al toxicity is much pronounced in acidic soil and several genetic studies were performed to map the locus responsible for Al tolerance in plants. A locus for Al tolerance, AltSB, was identified that encode a MATE via positional cloning in sorghum. This SbMATE has been shown to efflux the citrate from cell and forming non-toxic complexes with Al in soil solution. Similar to sorghum, MATE proteins from Hordeum, Arabidopsis, Triticum and maize have been shown to participate in Al tolerance. Tandem duplication of MATE paralogues in the maize genome have been demonstrated to offer another level of transcriptional regulation to provide adaptation of maize to Al toxicity.
Expression
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Evolution
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Structured Information
| Gene Name |
BGIOSGA000971 |
|---|---|
| Description |
Multidrug resistance protein 4 |
| Definition |
Oryza sativa Indica Group BGIOSGA000971, complete gene. |
| LocusTag |
CM800 |
| Ensembl Transcript ID |
BGIOSGA000971-TA |
| Ensembl Protein ID |
BGIOSGA000971-PA |
| Length |
6661 |
| Source |
Oryza sativa Indica Group ORGANISM Oryza sativa Indica Group
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP
clade; Ehrhartoideae; Oryzeae; Oryza.
|
| Chromosome | |
| Location |
Chromosome 1:32097824..32104484 |
| Sequence Coding Region |
32104215..32104484,32104074..32104128,32103051..32103226,32102551..32102772,32102214..32102452 |
| Genome Context |
<gbrowseImage1> name=IndicaChromosome01:32097824..32104484 source=RiceIndica01 preset=GeneLocation </gbrowseImage1> |
| Gene Structure |
<gbrowseImage2> name=IndicaChromosome01:32097824..32104484 source=RiceIndica01 preset=GeneLocation </gbrowseImage2> |
| Coding Sequence |
<cdnaseq>ATGGACGAGTCAGGCAGAGGAACAGGTGATGATCATGCCCGGGAGACGAAGGATGCTGCGGCGGCGGCGTCGTCGTCGTCGGGGAAGAAGGTGCCGCTGTTCAGCTTGTTCCGGTACGCCGACCGCCTCGACGTGCTGCTGATGGTTGTCGGCACGGTGGGCGCGCTCGGCAACGGCATCTCGCAGCCCCTCATGACGGTCCTCTTCGGCAACGTCATCAACTCCTTCGGCGCGAACACCAGCGGCAGCGTCCTCCGCAGCGTGACCAAGGTTGTCCTCAACTTCATATATCTGGGAATTGGAACTTCAGTAGCTTCCTTTCTTCAGGTATCATGCTGGACTATGGCAGGAGAAAGGCAGTCTGCCCGCATCCGTTCTTTATACCTGAAAGCCGTTCTGAGGCAGGATATTACATTCTTCGACACAGAGATGACAACTGGTGAAGCAGTTTCTAGAATGTCTAGTGATACCCTCCTAATTCAAGGTGCTCTTGGTGAGAAGGGAGGGAAGCTTGTAGAACTGTTATCAAGCTTCATCGGTGGCTTTATCATAGCATTCACTAGAGGATGGCTTCTCACTCTTGTCATGCTAACATCGCTACCGTTAATTGCTATTGCCGGTGCAGTTTCTGCACAGGCCCTAACTAGAGTTTCTAGCAAGAGACAAACATCATATAGTGATGCTGGGGACACAGTTGAACAGACCATTGGATCTATAAGAACAGTTGTGTCCTTCAATGGTGAGAAGAAAGCGATAGCAATGTACCGTAATTTTATAAAGAAGTCATACAAGGCTACTATTGAGGAAGGCATTATCACTGGTTTTGGCATGGGCTCTGTCATGTGCGTCGTATTTGGCAGCTATGGATTAGCCTTCTGGTATGGTGGAAAGCTAATCATTGAGAAAGGTTACACAGGAGGAAAAATCATGACTATCTTGTTTGCCGTGTTGACCGGTGCATCCTCATTAGGCAATGCAACACCTGCAGTTGCTGCAGTTGTGGAAGGTCAATCTGCAGCATACAATTTGTTCAAAACAATTGAGAGGAAACCAGAGATAGATTCCGATGATAACAATGGCATGGTTTTAGAAGATATGAATGGCGATATTGAGCTAAAGGATGTGTACTTTCGTTACCCTGCAAGACCAGAGCAGTTGATATTGGATGGATTGTCGTTACAAGTAGCGAGTGGAACAACAATGGCTATAGTCGGAGAGAGTGGAAGCGGAAAGTCAACTGTTATCAGCCTAGTCGAAAGATTCTACGATCCACAGTCTGGCGAAGTTTTAATAGATGGAATTAGCATCAAGAAACTGAGACTTGATTGGATAAGAGGGAAGATCGGTCTTGTTAGCCAAGAGCCTCTGCTTTTTATGGCCTCCATTAAAGATAACATAATATATGGTAAAAAAGATGCAACGCTTGAAGAGATCAAGAGAGCAGCGGAGCTTGCAAATGCAGCTAACTTCATTGACAAGTTACCAAATGGTTATGATACTTTAGTTGGCCAGCGCGGTACTCAGCTCTCTGGAGGACAAAAACAGAGAATTGCAATTGCAAGAGCCATCCTCAAAGATCCAAAAATCCTTTTGCTCGATGAAGCAACAAGTGCACTTGATGTGGAGTCTGAGAGGATAGTTCAGGAGGCACTAAATAGAATGATGGTAGAAAGAACCACACTCGTTGTCGCTCATCGTTTGAGCACTGTGAGGAATGTTGATTGCATCACAGTCGTCCGCAAAGGAAAAATAGTTGAACAAGGTCCTCATGATGCACTGGTGAAGGATCCCGATGGAGCTTACTCCCAGCTAATTAGGCTACAAGAGACTCATCGTGATGAAAGGCATAAACTACCAGATTCCAGATCAAAAAGTACTAGTTTGTCATTCAGACGATCAAGAACTAAAGATTTTCTCAGCAAGAGCAACAGGTATTCCTTCAAGAGCCCCTTAGGATTGCCTGTTGATATACATGAGGATGGAATGACAAGCGAACAACAAAAGGTTGACCACTCTGACAGTAAGGCCATTAAAAAAACACCATTTGGACGGCTTTTTAATCTTAATAAGCCAGAAGTGCCAGTTCTTTTGTTAGGTTCTATAGCAGCATCAGTGCATGGAGTCATTTTGCCACTATACGGTATAATAATGCCAGGTGTTCTAAAATCATTCTATGAACCGCCAGATCAGCTGCGAAAAGATTCTAGATTTTGGGCATTGATGTCTGTTGTTCTGGGGGTTGCTTGTTTGATTTCAATCCCAGCAGAATATTTTTTGTTTGGAATTGCTGGGGGAAAGCTTATACAGCGTGTCCGTACACTGTCATTTCAAAGAATTATGCACCAAGAGGTTGCTTGGTTTGATAAGCCCTCCAATTCCAGTGGGGCACTTGGTACAAGGCTCTCAGTCGATGCGTTGAATGTCCGCCGTTTAGTAGGAGATAACCTGGCCCTTATAGTCCAGGCTGTAGCTACACTAACCACTGGCTTTGCCATAGCTTTTGCGGCAGATTGGAGGCTTGCACTGATCATCACTTGTGTAATTCCTTTAGTGGGTGCACAGGGCTATGCTCAAGTTAAGTTCTTGAAGGGGTTCAGTGAAGAATCTAAGGAGATGTATGAGGATGCAAACCAAGTTGCGGCTGACGCTGTAGGCAGCATCAGAACTGTAGCATCTTTCTGTTCAGAGAAAAGAGTGGTGGCAATATACAACAAGAAATGTGAAGCTTTAAGAAAACAGGGAATTCGAAGCGGAATCGTTGGAGGGATTGGCTTAAGTTTCTCAAACTTGATGTTATATCTGACTTACGGTCTTTGCTTCTATGTTGGTGCAAAGTTCGTAAGTCAGGGAAAAACTACTTTTTCAGATGTTTTCAAAGTTTTCTTTGCTTTAGTTTTGGCAGCCGTTGGTGTTTCGCAGTCAAGTGCATTGTCTACTAATGCAACAAAGGCAAGGGATTCTGCCATTTCCATTTTTAGTATTATCGATCGGAAGTCTAGGATTGATTCAAGTAGCGACGAGGGAGCGATAATGGAAAACGTCACTGGCAGCATTGATTTCAATAATGTCAGTTTCAAGTACCCATCACGCCCTGATGTTCAAATATTCAGTGACTTTACCTTGCACATTCCTTCCCAAAAGACCATAGCACTTGTTGGAGAAAGCGGTAGTGGGAAATCCACGATAATTGCTTTATTAGAGCGTTTCTATGATCCTGATTCTGGTAATATCTCACTAGATGGAGTTGAAATTAGAAGCTTAAAAGTCAGCTGGTTGAGGGATCAGATGGGGCTTGTAGGCCAGGAGCCAGTGCTTTTCAACGACACAATCCGTGCCAACATAACATACGGGAAACACAGTGAGGTAACAGAGGAAGAGATCACTGCTGTGGCCAAGGCAGCAAACGCCCATGAGTTCGTATCAAGCCTGCCACAAGGATACGACACAGTGGTAGGTGAGAAAGGGGTGCAACTATCTGGTGGGCAAAAACAGAGGGTAGCAATTGCAAGGGCCATCCTAAAGGACCCTAAGATACTGCTACTTGATGAGGCAACCAGTGCTCTAGATGCAGAATCAGAACGTGTTGTTCAAGATGCATTGGATCGAGTCATGGTCAACAGGACTACCATTGTAGTGGCACACCGCCTCTCCACAATCAAAGGGGCTGATATGATTGCAGTCCTCAAGGAAGGAAAAATTGCAGAAAAAGGAAAGCATGAAGCACTATTGCGGATCAAGGATGGTGCATATGCTTCACTTGTACAACTCCGCTCTAATTCCGAGTAA</cdnaseq> |
| Protein Sequence |
<aaseq>MDESGRGTGDDHARETKDAAAAASSSSGKKVPLFSLFRYADRLDVLLMVVGTVGALGNGISQPLMTVLFGNVINSFGANTSGSVLRSVTKVVLNFIYLGIGTSVASFLQVSCWTMAGERQSARIRSLYLKAVLRQDITFFDTEMTTGEAVSRMSSDTLLIQGALGEKGGKLVELLSSFIGGFIIAFTRGWLLTLVMLTSLPLIAIAGAVSAQALTRVSSKRQTSYSDAGDTVEQTIGSIRTVVSFNGEKKAIAMYRNFIKKSYKATIEEGIITGFGMGSVMCVVFGSYGLAFWYGGKLIIEKGYTGGKIMTILFAVLTGASSLGNATPAVAAVVEGQSAAYNLFKTIERKPEIDSDDNNGMVLEDMNGDIELKDVYFRYPARPEQLILDGLSLQVASGTTMAIVGESGSGKSTVISLVERFYDPQSGEVLIDGISIKKLRLDWIRGKIGLVSQEPLLFMASIKDNIIYGKKDATLEEIKRAAELANAANFIDKLPNGYDTLVGQRGTQLSGGQKQRIAIARAILKDPKILLLDEATSALDVESERIVQEALNRMMVERTTLVVAHRLSTVRNVDCITVVRKGKIVEQGPHDALVKDPDGAYSQLIRLQETHRDERHKLPDSRSKSTSLSFRRSRTKDFLSKSNRYSFKSPLGLPVDIHEDGMTSEQQKVDHSDSKAIKKTPFGRLFNLNKPEVPVLLLGSIAASVHGVILPLYGIIMPGVLKSFYEPPDQLRKDSRFWALMSVVLGVACLISIPAEYFLFGIAGGKLIQRVRTLSFQRIMHQEVAWFDKPSNSSGALGTRLSVDALNVRRLVGDNLALIVQAVATLTTGFAIAFAADWRLALIITCVIPLVGAQGYAQVKFLKGFSEESKEMYEDANQVAADAVGSIRTVASFCSEKRVVAIYNKKCEALRKQGIRSGIVGGIGLSFSNLMLYLTYGLCFYVGAKFVSQGKTTFSDVFKVFFALVLAAVGVSQSSALSTNATKARDSAISIFSIIDRKSRIDSSSDEGAIMENVTGSIDFNNVSFKYPSRPDVQIFSDFTLHIPSQKTIALVGESGSGKSTIIALLERFYDPDSGNISLDGVEIRSLKVSWLRDQMGLVGQEPVLFNDTIRANITYGKHSEVTEEEITAVAKAANAHEFVSSLPQGYDTVVGEKGVQLSGGQKQRVAIARAILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKGADMIAVLKEGKIAEKGKHEALLRIKDGAYASLVQLRSNSE</aaseq> |
| Gene Sequence |
<dnaseqindica>1..270#357..411#1259..1434#1713..1934#2033..2271#3085..3610#3702..3975#4074..4692#4786..5014#5129..5395#5484..5747#6017..6661#ATGGACGAGTCAGGCAGAGGAACAGGTGATGATCATGCCCGGGAGACGAAGGATGCTGCGGCGGCGGCGTCGTCGTCGTCGGGGAAGAAGGTGCCGCTGTTCAGCTTGTTCCGGTACGCCGACCGCCTCGACGTGCTGCTGATGGTTGTCGGCACGGTGGGCGCGCTCGGCAACGGCATCTCGCAGCCCCTCATGACGGTCCTCTTCGGCAACGTCATCAACTCCTTCGGCGCGAACACCAGCGGCAGCGTCCTCCGCAGCGTGACCAAGGTGAGTGCCCGCGGGCGCTTAGTGATACGCGATGGAGACACACCGGCCGGTAGCCAAATTAACTTTGGATCTTCTTTCTCCTCCAGGTTGTCCTCAACTTCATATATCTGGGAATTGGAACTTCAGTAGCTTCCTTTCTTCGTAAGTAAAAGTCCTTTCTCTGATTGGAACACCTCTTTAGTGAAGTAGAGAGAAGCTCCTGCCCTTTTCGCTGAAAAAAACAAAGAAAAAAAAAGAATTAGTGGAACCTGTAGCTTCAAATTATGGATGTGAAACATATAAATAGTATTCAGCAAGGGAATTTGTAGTAAACAGTATTAGAAATTCTTTCAATATCTAATTTGTTCCTATTATTCAATGAGTCTCCGGGTATCCATAAGTCAATAAGAAATTTCATTTAAAGGGTCTCAGAGTATCCATCAGATTCCAAAGCAAAATTAACACTTTTTATTCAAAGGGTCTCAGTATCCATAAGTCAGTAAGAAATTTTGTAGGATAGTGTGAAATTAGGCTTTGTTTGGTAAATGGGATTGAGAAATAATATCCCACCCTCCAAAAGGTAATATTGCATCCTAGCTATCCATTCTTCACACCTCATTTAATCCTAGCCATTTATTCTTTACACCTCATTTAATCCTAGTCATTCATCCATTTCCATTTCCCAATCCCACCTGCCATATCCCATTTGCCAAACACACCCTTAGGATAAGTAATTAATTTGCTCTTGCATGGATGCGCAATCACCAATACATAATATTCATTATTAACATCATGGTTGTCAGTTGTTACTACATGTTAGAATTCGGTTATTCTCAACTGTGATACACTAACACAGTATAAACATCATCATGCACTTATCCGGTGAGAAGTACCAAATGCGTTCCCTAACCATATAATCCTCAGCATCTTCGATCTAATCTGTTCGGTTAAATATATCACATGCTAATGGTACAACTGCCAGTAAAAAACTCACCTTAATTTGTCCCAGAGGTATCATGCTGGACTATGGCAGGAGAAAGGCAGTCTGCCCGCATCCGTTCTTTATACCTGAAAGCCGTTCTGAGGCAGGATATTACATTCTTCGACACAGAGATGACAACTGGTGAAGCAGTTTCTAGAATGTCTAGTGATACCCTCCTAATTCAAGGTGCTCTTGGTGAGAAGGTACTAAATACCTAGTAGCTCCCTTGTAAGGAACATACTATTTTTTATTAAATTGCTACTGAAAAAAAAAAACATATATTTTCATCACAGTGCAAACAAAAGTGTGGATAGACACAAGTTGATGGCAGGCATAATTATTTGCATATTTAGGAAGATATATCAAACGGATATAGTTATCATATTTACTAACTGTATTATTTCATATATTCAGGCAGTAAGTTGCACCTTGTGCTACTGTTGCTGATGTGTTCTTGGATTTTTAATCTTAACCTTTACAGGGAGGGAAGCTTGTAGAACTGTTATCAAGCTTCATCGGTGGCTTTATCATAGCATTCACTAGAGGATGGCTTCTCACTCTTGTCATGCTAACATCGCTACCGTTAATTGCTATTGCCGGTGCAGTTTCTGCACAGGCCCTAACTAGAGTTTCTAGCAAGAGACAAACATCATATAGTGATGCTGGGGACACAGTTGAACAGACCATTGGATCTATAAGAACAGTGAGTTTCACATATTTATATGAATTGTTTAATGCTATAACACACTTCTTTTTTTGGAGTAGCAGACAGTAAGTTTGATAAATATCCTGTGTTAACAGGTTGTGTCCTTCAATGGTGAGAAGAAAGCGATAGCAATGTACCGTAATTTTATAAAGAAGTCATACAAGGCTACTATTGAGGAAGGCATTATCACTGGTTTTGGCATGGGCTCTGTCATGTGCGTCGTATTTGGCAGCTATGGATTAGCCTTCTGGTATGGTGGAAAGCTAATCATTGAGAAAGGTTACACAGGAGGAAAAATCATGACTATCTTGTTTGCCGTGTTGACCGGTGCATCGTAAGTTTCAGCAAATCCTCCACTGTTGATATCAAAATACATGCTGTTTAGTGCACTACAATAATGAACCCCCAATCTATTCATGTATTATTTGGATTGATGGAAATATAACAAGAAATTTATATATATTACCTCAAAATCAAGAAGGCTGGTTAGCATGCAATTTTAGAAGTGCAAATGGCAGTTTTGTTCATTTCTCAGGTGTTTTTTAGAAAACTTCTCAGGATTTCAAGATGATTTTCAGAATTACCTTAAATTATTTTCAATATTTTCTTGATTACTATTTACAAAAAGACAATGCTAATTGCCAATGCATGAAAGTAACTTGTTTCTTGTAAACAGAATGGAATGAACTTAAAGTTTGATGGTCAAGTCAATTGCTTGACTATACATAATCCCTAGGCCCTATTACCATTTTAGGCAGACATACCAATTGCTAAGGAGTAGTTATTAATTCCAGTTAGTAAAAGGGGATCATGAACTGAGATATAGACATAAGTACCTAATAGCTAAATCAAGGTATCCTTAGCAATTGCAAGAGCAGGTTTAATCAATATGTTCTGCGCTAACAGGAGAAGTAGACAAACGCTAGGCTTTTGGAATCGTCACGAAGAGAATATTCTCCTGAGAAGTACATTACATGTTATATGCAAACGATTGCATTGGGTTTCACTGCTTTACCTACATTACTTGCTATTTCTCCTAAAATCACATTAAAGTTGAAAGATTTACAACAAAATAGCCATTAAAATTTTATCATTTGATATGGTATATAATGTTCTGAACATGGCACTTTCCAATTGTTTGTGACAGCTCATTAGGCAATGCAACACCTGCAGTTGCTGCAGTTGTGGAAGGTCAATCTGCAGCATACAATTTGTTCAAAACAATTGAGAGGAAACCAGAGATAGATTCCGATGATAACAATGGCATGGTTTTAGAAGATATGAATGGCGATATTGAGCTAAAGGATGTGTACTTTCGTTACCCTGCAAGACCAGAGCAGTTGATATTGGATGGATTGTCGTTACAAGTAGCGAGTGGAACAACAATGGCTATAGTCGGAGAGAGTGGAAGCGGAAAGTCAACTGTTATCAGCCTAGTCGAAAGATTCTACGATCCACAGTCTGGCGAAGTTTTAATAGATGGAATTAGCATCAAGAAACTGAGACTTGATTGGATAAGAGGGAAGATCGGTCTTGTTAGCCAAGAGCCTCTGCTTTTTATGGCCTCCATTAAAGATAACATAATATATGGTAAAAAAGATGCAACGCTTGAAGAGATCAAGAGAGCAGCGGAGCTTGCAAATGCAGCTAACTTCATTGACAAGTTACCAAATGTAAGAAAGGAAAAACTGAATGCTCCAAGTTCTCAAATTTAATTGTATATTAATGAAATAATCAGCTAACAATGTTTTCATGTCATACCAGGGTTATGATACTTTAGTTGGCCAGCGCGGTACTCAGCTCTCTGGAGGACAAAAACAGAGAATTGCAATTGCAAGAGCCATCCTCAAAGATCCAAAAATCCTTTTGCTCGATGAAGCAACAAGTGCACTTGATGTGGAGTCTGAGAGGATAGTTCAGGAGGCACTAAATAGAATGATGGTAGAAAGAACCACACTCGTTGTCGCTCATCGTTTGAGCACTGTGAGGAATGTTGATTGCATCACAGTCGTCCGCAAAGGAAAAATAGTTGAACAAGGTTGAATTAACTTGAAATGCACTGTTTTTCTATTATAGAAAATTTCTGCGGTCAACCTTAAATGATTCATTATACCAAAACATGTCCTGCGTACACAGGTCCTCATGATGCACTGGTGAAGGATCCCGATGGAGCTTACTCCCAGCTAATTAGGCTACAAGAGACTCATCGTGATGAAAGGCATAAACTACCAGATTCCAGATCAAAAAGTACTAGTTTGTCATTCAGACGATCAAGAACTAAAGATTTTCTCAGCAAGAGCAACAGGTATTCCTTCAAGAGCCCCTTAGGATTGCCTGTTGATATACATGAGGATGGAATGACAAGCGAACAACAAAAGGTTGACCACTCTGACAGTAAGGCCATTAAAAAAACACCATTTGGACGGCTTTTTAATCTTAATAAGCCAGAAGTGCCAGTTCTTTTGTTAGGTTCTATAGCAGCATCAGTGCATGGAGTCATTTTGCCACTATACGGTATAATAATGCCAGGTGTTCTAAAATCATTCTATGAACCGCCAGATCAGCTGCGAAAAGATTCTAGATTTTGGGCATTGATGTCTGTTGTTCTGGGGGTTGCTTGTTTGATTTCAATCCCAGCAGAATATTTTTTGTTTGGAATTGCTGGGGGAAAGCTTATACAGCGTGTCCGTACACTGTCATTTCAAAGAATTATGCACCAAGAGGTTGCTTGGTTTGATAAGCCCTCCAATTCCAGGTGCGCTACTCTAATGTACTTTTGCTATTTTATCTTTTATAAAAAAATATTTACATTTAAACCAATGCTAAGAGGCCATCTTATTTCTTACAGTGGGGCACTTGGTACAAGGCTCTCAGTCGATGCGTTGAATGTCCGCCGTTTAGTAGGAGATAACCTGGCCCTTATAGTCCAGGCTGTAGCTACACTAACCACTGGCTTTGCCATAGCTTTTGCGGCAGATTGGAGGCTTGCACTGATCATCACTTGTGTAATTCCTTTAGTGGGTGCACAGGGCTATGCTCAAGTTAAGTTCTTGAAGGGGTTCAGTGAAGAATCTAAGGTGACACATTACAGCTTACAACTGTAAAAATTGCTTGCTGTTTTATTGAGAATGATCTAGACAAGTGATCTAGAATTAAATTGATTGCCATTATAATGGGATCTCATTATACAGGAGATGTATGAGGATGCAAACCAAGTTGCGGCTGACGCTGTAGGCAGCATCAGAACTGTAGCATCTTTCTGTTCAGAGAAAAGAGTGGTGGCAATATACAACAAGAAATGTGAAGCTTTAAGAAAACAGGGAATTCGAAGCGGAATCGTTGGAGGGATTGGCTTAAGTTTCTCAAACTTGATGTTATATCTGACTTACGGTCTTTGCTTCTATGTTGGTGCAAAGTTCGTAAGTCAGGGAAAAACTACTTTTTCAGATGTTTTCAAAGTAAGAAATCCTAAAGTATTTCAAGTAACAATTGCCTATATGAATATTAATTCTAGTATCATTCACAAATGGGCTGGATGCTTTTCAGGTTTTCTTTGCTTTAGTTTTGGCAGCCGTTGGTGTTTCGCAGTCAAGTGCATTGTCTACTAATGCAACAAAGGCAAGGGATTCTGCCATTTCCATTTTTAGTATTATCGATCGGAAGTCTAGGATTGATTCAAGTAGCGACGAGGGAGCGATAATGGAAAACGTCACTGGCAGCATTGATTTCAATAATGTCAGTTTCAAGTACCCATCACGCCCTGATGTTCAAATATTCAGTGACTTTACCTTGCACATTCCTTCCCAAAAGGTATACTTCCACATTCACCTATTTGTCTTCCTTTTTCCTATTTCTTGAAACTAGTGCATGCCCAAAATTTCCATCAGAAAATTAACTTGATTATTGAACTATTTACATAATACAACTAGTAACATACTTCAAAATAGATGCGAGTGTGACCCATCCACTTCCGTGACATCATATGTGTTGATACACAACTTTACATTTTATTTTTTGCATCTCAGCATTTCCATGCACTGAAATAGTTATGACTAAACCTTTTCCTTCCTTTTCTACAGACCATAGCACTTGTTGGAGAAAGCGGTAGTGGGAAATCCACGATAATTGCTTTATTAGAGCGTTTCTATGATCCTGATTCTGGTAATATCTCACTAGATGGAGTTGAAATTAGAAGCTTAAAAGTCAGCTGGTTGAGGGATCAGATGGGGCTTGTAGGCCAGGAGCCAGTGCTTTTCAACGACACAATCCGTGCCAACATAACATACGGGAAACACAGTGAGGTAACAGAGGAAGAGATCACTGCTGTGGCCAAGGCAGCAAACGCCCATGAGTTCGTATCAAGCCTGCCACAAGGATACGACACAGTGGTAGGTGAGAAAGGGGTGCAACTATCTGGTGGGCAAAAACAGAGGGTAGCAATTGCAAGGGCCATCCTAAAGGACCCTAAGATACTGCTACTTGATGAGGCAACCAGTGCTCTAGATGCAGAATCAGAACGTGTTGTTCAAGATGCATTGGATCGAGTCATGGTCAACAGGACTACCATTGTAGTGGCACACCGCCTCTCCACAATCAAAGGGGCTGATATGATTGCAGTCCTCAAGGAAGGAAAAATTGCAGAAAAAGGAAAGCATGAAGCACTATTGCGGATCAAGGATGGTGCATATGCTTCACTTGTACAACTCCGCTCTAATTCCGAGTAA</dnaseqindica> 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| External Link(s) |
