Os06g0600400

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Annotated Information

Function

Rice CYP734As are multifunctional, multisubstrate enzymes that control the endogenous bioactive brassinosteroid content both by direct inactivation of CS and by the suppression of CS biosynthesis by decreasing the levels of brassinosteroid precursors.In addition, rice CYP734As can catalyze hydroxylation and the second and third oxidations to produce aldehyde and carboxylate groups at C-26 in vitro.Two P450s,CYP734A1/BAS1 and CYP72C1/SOB7/CHI2/SHK1, also act in the inactivation of brassinosteroids by means of different enzymatic activities.

Expression

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Expression of CYP 734A genes in wild-type and mutant rice.

Evolution

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Labs working on this gene

1,overexpression of CYP734A genes in transgenic rice. 2,isolation of CYP734A1/BAS1-like genes from rice. 3,catalytic activities of rice CYP734As. 4,determination off the position oxidized by CYP734A2. 5,substrate specificity of CYP734A2.

References

Please input cited references here. 1. Tomoaki Sakamoto;Ayami Kawabe;Asako Tokida-Segawa;Bun-ichi Shimizu;Suguru Takatsuto;Yukihisa Shimada;Shozo Fujioka;Masaharu Mizutani Rice CYP734As function as multisubstrate and multifunctional enzymes in brassinosteroid catabolism. The Plant Journal, 2011, 67(1): 1-12 2,Bak, S., Paque tte, S., Morant, M. et al. (2006) Cyanogenic glycosides: a case study for evolution and application of cytochromes P450. Phytochem. Rev.5, 309–329. 3,Bak, S., Paquette, S., Morant, M. et al. (2006) Cyanogenic glycosides: a case study for evolution and application of cytochromes P450. Phytochem. Rev.5, 309–329. Bishop, G.J. (2007) Refining the plant steroid hormone biosynthesis pathway.Trends Plant Sci. 12, 377–380. 4,Clouse, S.D. and Sasse, J.M. (1998) Brassinosteroids: essential regulators of plant growth and development. Annu. Rev. Plant Physiol. Plant Mol. Biol.49, 427–451. 5,Clouse, S.D., Langford, M. and McMorris, T.C. (1996) A brassinosteroid-insensitive mutant in Arabidopsis thaliana exhibits multiple defects in growth and development. Plant Physiol. 111, 671–678.