Os07g0257200

The rice Os07g0257200 was reported as OsNRAMP5 three times by Japanese researchers in 2012.

Annotated Information

Figure 1. Wild-type lines VS. NRAMP5 knock-out lines (from reference).

Function

• The plant Natural resistance associated macrophage protein (NRAMP) gene family play an important role in the transportation of metal ions and maintaining their intracellular homeostasis. As a member of rice NRAMP gene family, OsNRAMP5 is a major transporter responsible for Mn uptake in the roots.
  

• It can participate in the major route for Cd entering the root cells from the external environment in rice. The research by Yasuhiro Ishimaru also pointed out that OsNRAMP5 would function as a Fe and Mn transporter during flowering and seed development.

Wild Type & Mutations

• The Nramp5 Knockout Line reported by Akimasa Sasaki in 2012 showed that the growth of both the mutant shoots and roots was less than that of wild-type rice without any heavy metal ions treatments. And severe chlorotic symptoms could be found in the leaves of the Nramp5 knockout line.
  
• When treated with heavy metal ions, no significant difference was observed in the concentration of Zn and Cu for the roots and shoots between the mutants and wild-type line. While both the concentration of Mn and Cd in the mutant roots and shoots was remarkably lower than in the wild-type line (Figure 1).

Expression

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Evolution

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Labs working on this gene

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References

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Structured Information

Gene Name	Os07g0257200
Description	Similar to OsNramp1 (Integral membrane protein)
Version	NM_001065847.1 GI:115471426 GeneID:4342859
Length	7263 bp
Definition	Oryza sativa Japonica Group Os07g0257200, complete gene.
Source	Oryza sativa Japonica Group ORGANISM Oryza sativa Japonica Group Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza.
Chromosome	Chromosome 7
Location	Chromosome 7:8903800..8911062
Sequence Coding Region	8904093..8904425,8905435..8905530,8906126..8906257,8907244..8907348,8907630..8907803 ,8908094..8908163,8908263..8908444,8908669..8908778,8909778..8909882 ,8909965..8910043,8910342..8910382,8910511..8910589,8910856..8910966
Expression	GEO Profiles:Os07g0257200
Genome Context	<gbrowseImage1> name=NC_008400:8903800..8911062 source=RiceChromosome07 preset=GeneLocation </gbrowseImage1>
Gene Structure	<gbrowseImage2> name=NC_008400:8903800..8911062 source=RiceChromosome07 preset=GeneLocation </gbrowseImage2>
Coding Sequence	<cdnaseq>atggagattgagagagagagcagtgagagagggagcatcagctggagagctagtgcggcacatgatcaagatgccaagaagctcgacgcagatgatcagctgctaatgaaggagcctgcatggaaaaggttccttgcccatgttggtcctggattcatggtgtctttagcctacttggatcctggcaatttggaaaccgatctgcaagccggagccaaccacagatatgagctgctctgggtgattctgattggactcatcttcgcacttatcatacagtcgctagcagctaatcttggagtggttacagggaggcatctggctgagatctgcaagagtgagtaccccaagttcgtcaagattttcctatggctgctggcagagttggccgtcatcgctgcagatatcccagaagttatagggacggcctttgctttcaacatattgttccatattccggtgtgggtcggcgtcctcatcaccggcaccagcactctactgcttcttggcctccaaaaatacggggtgaggaagctggagtttctgatatcgatgctggtgttcgtgatggcggcgtgcttcttcggggagctgagcatcgtgaagccgccggcgaaggaggtgatgaaggggctcttcatccccaggctcaacggcgacggcgccaccgccgacgccattgccctcctcggagctcttgtcatgccccacaatctgttcttgcattctgccttggtgctatcgaggaagacaccggcatcagtcagaggaatcaaggacgggtgcaggttcttcctgtacgagagcgggttcgcgctgttcgtggcgctgctgataaacatcgccgtcgtctccgtctccggcaccgcctgctcctccgccaacctctcccaagaggacgccgacaagtgcgccaacctcagcctcgacacctcctccttccttctcaagaacgtgctgggcaagtcgagtgcgatcgtgtacggcgtggcactgttggcatctgggcagagctccactattaccggcacatacgctggacagtacatcatgcagggtttcttggacatcaggatgaggaagtggcttcggaacctgatgacaagaaccatcgccatcgcgccgagcctcatcgtctccatcatcggcggctccaggggcgccggccgcctcatcatcatcgcttcgatgatactgtccttcgagctgccgtttgctctcatccctcttctcaagttcagcagcagtaagagcaagatggggccccacaagaactctatctatataatagtgttctcgtggttcctgggtctgctcatcatcggcatcaacatgtacttcctgagcacgagcttcgtcggctggctcatccacaacgacctccccaagtacgccaacgtgctcgtcggcgccgccgtcttcccgttcatgctcgtctacatcgtcgccgtcgtctacctcaccatcaggaaggactccgtcgtcaccttcgtcgccgactcctccctcgccgccgtcgtcgacgccgagaaggccgacgccggcgacctcgccgtcgacgacgacgagcccttgccgtaccgcgacgacctggccgacatcccgctcccaaggtag</cdnaseq>
Protein Sequence	<aaseq>MEIERESSERGSISWRASAAHDQDAKKLDADDQLLMKEPAWKRF LAHVGPGFMVSLAYLDPGNLETDLQAGANHRYELLWVILIGLIFALIIQSLAANLGVV TGRHLAEICKSEYPKFVKIFLWLLAELAVIAADIPEVIGTAFAFNILFHIPVWVGVLI TGTSTLLLLGLQKYGVRKLEFLISMLVFVMAACFFGELSIVKPPAKEVMKGLFIPRLN GDGATADAIALLGALVMPHNLFLHSALVLSRKTPASVRGIKDGCRFFLYESGFALFVA LLINIAVVSVSGTACSSANLSQEDADKCANLSLDTSSFLLKNVLGKSSAIVYGVALLA SGQSSTITGTYAGQYIMQGFLDIRMRKWLRNLMTRTIAIAPSLIVSIIGGSRGAGRLI IIASMILSFELPFALIPLLKFSSSKSKMGPHKNSIYIIVFSWFLGLLIIGINMYFLST SFVGWLIHNDLPKYANVLVGAAVFPFMLVYIVAVVYLTIRKDSVVTFVADSSLAAVVD AEKADAGDLAVDDDEPLPYRDDLADIPLPR</aaseq>
Gene Sequence	<dnaseqindica>6638..6970#5533..5628#4806..4937#3715..3819#3260..3433#2900..2969#2619..2800#2285..2394#1181..1285#1020..1098#681..721#474..552#97..207#gtcactaccaccattctcttcttcgtctacttccagctagcctgagctctagcttagctctagcttagcctgaagaagctaagagaggaagcaacaatggagattgagagagagagcagtgagagagggagcatcagctggagagctagtgcggcacatgatcaagatgccaagaagctcgacgcagatgatcagctgctaatgaaggtcagttgctaccttaattatcacaaagttgtcttcttgtaagcactccactgtcaccatggacagttgttcactgtaactgcagaagcaagagcagagcttaatgtagatagatcttgagagtacttcctggcatggcattcattgctcatgaatgttcatgtgtgtgtgtgtatgtggtaattaaggactgatggaacattggatcctcaattatgtctgtgtttctttttgttagtttctcagttttggtaaattgtgtacaggagcctgcatggaaaaggttccttgcccatgttggtcctggattcatggtgtctttagcctacttggatcctggcaattgtgagaatctctctctctctctctctctctctctctctctctctctctctctctctctctctcaactgaaacttttattttgacaaactctggattgtaactgttaattttgtcacaaaatgaaacagtggaaaccgatctgcaagccggagccaaccacagatatgaggtacgtacagtcgactttattttactgtttacgcactgaatgactgaaagcatgagtaactttcatgctttctaggtgttcgtccctttccttgtccctcgcagactcacactccattaattcatctgctagctccatcaaattctccaaattgacaaacttttcagaaccacttttaatccccagtgcatatgtatctcactctcacatcatctagagaaaagagaaaagtgaataatctgcaccattaattgatttctatgtgcttttctgtccattgtgttgtttcaatttgcagctgctctgggtgattctgattggactcatcttcgcacttatcatacagtcgctagcagctaatcttggagtggttacaggtgactaaatgacacgcaattaaactgtaattaccaacttgataaagtgctaatatatggccggcattaatttacatcctagggaggcatctggctgagatctgcaagagtgagtaccccaagttcgtcaagattttcctatggctgctggcagagttggccgtcatcgctgcagatatcccagaaggtatatacttattagtaacaacttgacacggtccagcctgaataattaatttattaaactacttgtgtttaacagtgtcaccatctttgactttgagctaattaattaattcagtttaagctctctgacagtagaagaaaacaagttgatctggctagcatatgtagctccaaccgtacgggcctacatactggaattcctaatccacaaacataggcaaattaatatctcaccaatcaccatcaagccacgttcttctcagctactcaccagattattctcacatattatttctttcatgtctctagctagtaaatatgtttttctaaaaaaaatatattctgcgatattgcatagaatacaagttctaagccattttttaaaaaaatatttaattcatccatataataaggtagataatatgtaccaataatatatctgttgaataatctgtttcaaacataagcaaatgcgcgttttagctgtttagaggagtgaccacgtccacagtagcttcccataaaagtgtcaatgatgcacatcaagattagattttaaacactgggtgagtacgttcatcatcttacgcagattagtaaacaactattttgtcaccctcttgtcatttcacatttgtcctgtcctgtatacatccatgtgtgtttaaacaataacaacaatatctaaatatctatctatctagcaacatggaagagagatcagtggtgtagcagttgcaaaacggagctgcgcgaagctttgctgatcgggattagttaacctcaaccgttgtaaattgcctttttaattgatcatgcatgcaagttcttttttaaaaaaattaaactagttatggaagatacctcacatgatgatagcaaaggtgatatatagatagatagatagatcgatcaacagatagaaaggtacagatcgatgtgattataattaattaattaattacatgtcgtttgatgttgttaattttggtggatgcagttatagggacggcctttgctttcaacatattgttccatattccggtgtgggtcggcgtcctcatcaccggcaccagcactctactgcttcttggcctccaaaaatacggggtataaattattttttgtaagttgtttttgtttagtatcacaagcattagcgtaggatgcactcaaagaaacgattataaaaatggaatagtatatgaaattagctagttggatcgattgtcaagtactcaaatggcatattatatgtacattattcagttttttttctctgactgtggaactgcatgaaaattgattgatgaattttttttgaaaaaaaacaggtgaggaagctggagtttctgatatcgatgctggtgttcgtgatggcggcgtgcttcttcggggagctgagcatcgtgaagccgccggcgaaggaggtgatgaaggggctcttcatccccaggctcaacggcgacggcgccaccgccgacgccattgccctcctcggagctcttgtcatgccgtacgcttttacatacatacatacatacgcaacaatcaatcaattaattcatacaactaatcagttaattaactactgcatgcatttatatatatgcagccacaatctgttcttgcattctgccttggtgctatcgaggaagacaccggcatcagtcagaggaatcaaggtagctatattcagcctgggcagatcgagataggtatagggtagctaggacatgaactcgatctagtcctgtctcttaaatcttgtttaaattttattaaattaacatgtaaatttcatagaaaaccaatactttattagctaagttttattttagcactaatcttctataatttcgggctccagtaccactggattcagcttagaattttttcatgcatggaaagaaaccgaacaaagatccaggctaataattaatatgtactatatggtgtgtgaattgccacgtaggacgggtgcaggttcttcctgtacgagagcgggttcgcgctgttcgtggcgctgctgataaacatcgccgtcgtctccgtctccggcaccgcctgctcctccgccaacctctcccaagaggacgccgacaagtgcgccaacctcagcctcgacacctcctccttccttctcaaggtcattcattcattattacttcctactccttaatattaaaaatttttaaatggattagacgtatcctagtactacagatagaaatctattcagattcgtagtactagcttgtatgtgttcaatttaatcaatatttaattaaccacaataataccgaattagtctacacgatttctccgtcctaaaatataataactttattagatatgtttatatttttgaataggaggagtaactaatttatggtcaaattgtgacgtcaatttttttatgtggttcagaacgtgctgggcaagtcgagtgcgatcgtgtacggcgtggcactgttggcatctgggcagagctccactattaccggcacatacgctggacagtacatcatgcaggtaattaattaaattaattaacttaactgtacctgtacctgtacatcaccagctagcttagcgcgtaattaaatgattgaactataattaattaaacggctagctgccacataattaatttgttaatccgttcaattatggaggttaactgacgaattgtaggggtgcacacctaatcctgtttacatcacgaatatttagtgatataatattcctttattaattaggtaatctggcgatcctcgtcggatttcaccatatgtttttgttaaagtcagatcgaattaagacgctaccttgctgccactacttaccactttcgtccatatttctccgctcttttggtctagtccatttcacggtgcagtctcatcaataaccagcgattttactgtttacatatacttagaaaaccaattgattaataaaaatatgctaacgaaactctataaattatattaaaaaaaataggatatcccatcgcaccgtaaaattttctttctgaagtgaacgttgagaaagagaacaactagttttcctaatctacctggcgggctaaccgatctagttcgagtctcattcctcttaataatctatttatgatatgaagcgtatttcagttacgggataaatcggacccgaaaatatatatttattttttcactccaaaggactgatcttcaggatatactcactccgtctctaaatatttgacgtcgttgactttttataaatatgtttgaccgttcgtcttatgcaaaaacttttatgaatattatttaaaaaactagagtagtagtagtatatacaacaatgaatcaaatgataagaaaagaattaataactacttaaatttattgaataagatgaatggttaaacatgtttagaaaaatcaacggcgtcaaatatttaatgacggaaggagtatatgataaatcatcatcatgtcgcgttgatatatatgatatgatccatgtatgtgcagggtttcttggacatcaggatgaggaagtggcttcggaacctgatgacaagaaccatcgccatcgcgccgagcctcatcgtctccatcatcggcggctccaggggcgccggccgcctcatcatcatcgcttcggtcagcatttttattattactatttactatagcaaatctttactattattactattttactatagcaaactgcgtgcgccatacggcggcgcccgccggcgagcaaccggccggccgtcgtgtcgccgatcgattaaaatttaatgcgtttaaatttttaattttgcacatgcccaaacagtcacgtgtgtgcagtcgatcgtgcggatttatgtagctagctaggtagtagtggggtatccactaggtacctagtgacatagtactaagagcatatatatatgtcattagagcaaaagcactttttcttctttttttagattattgccaaatcaaagtagtgatctgattagcaaaatgtcactgactagctaggtatcttttctttttttgcaatctgatctaaaatagcaccatgcatatatataatacagtgtaccatctagctagactagcttccaactcaataagtaaggactaattatatataattaaatcaaatcaaagtagtgatctgatcattgctagttcttgtttgcttaattacatatatatgattaattgttcctaatccgtacgtgttgtgtgcatgcagatgatactgtccttcgagctgccgtttgctctcatccctcttctcaagttcagcagcagtaagagcaagatggggccccacaagaactctatctatgtaagatcgtacactatatatatgcattgcttaattatagtttgtttcttaatctcaattggcagcaaatgtacaagtaacataaatatatgcatctatctgtccatgcatgaaattagagtttcaataattgttggtaaagaatataaattaatgatgatagttggctagctagctggtccttcaccctgcatgcatgcaacccctacaggacaccatgttctataggtcagtgtgtgcataatatagatcgagatgtgcagtgaattgaattgaatcattagctacctagctcatgcaatagtattatagcacagcaggggccaatgcaggacaggtatatatatggtccagccatgcatatagaggatcgtcgtacatatgaaaacgacgaccaagatgtacgtcctgcatcatttttctgtcttgcagtagtaccagagattaatcatgtattgcgtcgtcggcatgatgtgtcaaaatcatgcagtaacgtacttgcttgatctttacagacatcgaagagccaagttcttcagtacactatatatattttttcttgcatggaagtaaaatgtaaatataatttaacatagatcattacgtatgtcgttgtatctctacttaaacatttctagacacatacaagtcaacattagaaaatgtaattcttttttaaggaccataaataaactgatctacaacaaaattgaacaaatgtaaatttatttcttattattacacacatggctatatatatatatatatatgtgtgtgtatatatatatatatgtgtatatatatatatgtgtatatatatatatatatatatatgtatatatatatatatatactacctataaaaattgcgcatgctcatcagtcgatacccgttaaaaagatatataagttaccacccgtcaaagatgactggttatttagtgacgctatcaatgaattaattagcgtcatgtatgtcaaaaaataaattgaattgaattgaatgcagataatagtgttctcgtggttcctgggtctgctcatcatcggcatcaacatgtacttcctgagcacgagcttcgtcggctggctcatccacaacgacctccccaagtacgccaacgtgctcgtcggcgccgccgtcttcccgttcatgctcgtctacatcgtcgccgtcgtctacctcaccatcaggaaggactccgtcgtcaccttcgtcgccgactcctccctcgccgccgtcgtcgacgccgagaaggccgacgccggcgacctcgccgtcgacgacgacgagcccttgccgtaccgcgacgacctggccgacatcccgctcccaaggtagagaagaagaagatcgacatgcatacgtatggtatagcgtatgtatacgtacgtatatacgcgtacattgtgaatatacgtacttacgtacgtatatgtgcatcctctatggatgccacgtgcgtgcgtcggagccgttcgtttatatttgtgcggtccagatcgctcgcagatcgatcgatcgacaagggtgtgcaattaatatataagcatttgaggggaggtggctcatgtatccttgtaatttatatgtacgatatgatttatcataattcagggcagagccaacgtcct</dnaseqindica>
External Link(s)	NCBI Gene:Os07g0257200, RefSeq:Os07g0257200