BIG Search is a scalable text search engine built based on ElasticSearch (a highly scalable open-source full-text search and analytics engine based on Apache Lucene). It features cross-domain search and facilitates users to gain access to a wide range of biomedical data, not only from NGDC databases but also partner databases throughout the world.
Total 13 record(s) from NODE
| project: A novel combination of decitabine and etoposide greatly improves the survival of TP53 mutation AML/MDS patients by targeting Notch1 signaling pathway
description: selected the TP53 mutation (THP-1 and U937) and TP53 WT (MOLM13) AML/MDS cell lines and treated
title: A novel combination of decitabine and etoposide greatly improves the survival of TP53 mutation AML/MDS patients by targeting Notch1 signaling pathway
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| experiment: OEX_Jiexian_2304021031
description: selected the TP53 mutation (THP-1 and U937) and TP53 WT (MOLM13 and OCI ) AML/MDS cell lines and
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| experiment: OEX_Jiexian_2108201709
description: selected the TP53 mutation (THP-1 and U937) and TP53 WT (MOLM13) AML/MDS cell lines and treated
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| project: Combination of decitabine and epitoside is highly effective in treating p53-mutated MDS/AMLmds via activating notch signaling
description: selected the TP53 mutation (THP-1 and U937) and TP53 WT (MOLM13 and OCI ) AML/MDS cell lines and
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| project: Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma
title: Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma
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| project: Genomic characterization of pancreatic cancer
description: mutations, KRAS, TP53, CDKN2A, SMAD4, ARID1A, TGFBR2 were significantly mutated. Gene mutations of KRAS,, TP53, CDKN2A, and SMAD4 were identified in 91%, 65%, 27%, and 23% of patients, respectively
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| project: Genome-wide CRISPR screens identify PKMYT1 as a therapeutic target in pancreatic ductal adenocarcinoma
description: -essential depending on TP53 mutation status. Higher PKMYT1 expression levels indicate poor prognosis in
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| project: Integrated Proteogenomic Characterization of HBV-related Hepatocellular carcinoma
description: subgrouping and involved in HCC metabolic reprogramming, were identified. CTNNB1 and TP53 mutation
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| project: Proteogenomic Characterization Identifies Clinically-relevant Subgroups of Intrahepatic Cholangiocarcinoma
description: revealed that TP53 and KRAS co-mutations may contribute to iCCA metastasis via the integrin-FAK-SRC
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| project: M-DNB Factors Orchestrate Cell Fate Determination at Tipping Points during Mesendodermal Differentiation of Human Embryonic Stem Cells
description: regulators/M-DNB factors (FOS, HSF1, MYCN, TP53 and MYC) of this process based on the time-course single-cell transcriptomic analyses.
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