CORG


17135197	Developments in CORG: a gene-centric comparative genomics resource. [PMID: 17135197] Dieterich C, Franz MW, Vingron M. Abstract The CORG resource (Comparative Regulatory Genomics, http://corg.eb.tuebingen.mpg.de) provides extensive cross-species comparisons of promoter regions in particular and whole gene loci in general. Pairwise as well as multiple alignments of 10 vertebrate species form the key component of CORG. We implemented a rapid alignment approach based on weight matrix motif anchors to ensure efficient computation and biologically informative alignments. All CORG workbench components have been enhanced towards more flexibility and interactivity. Reference sequence based data presentation and analysis was put into the well-known and modular Generic Genome Browser framework. Herein, various plugins facilitate online data analysis and integration with static conservation data. Main emphasis was put on the design of a new JAVA WebStart application for comparative data display. Flexible data import and export options for standard formats complete the provided services. Nucleic Acids Res. 2007:35(Database issue) \| 2 Citations (from Europe PMC, 2025-03-22)
12519946	CORG: a database for COmparative Regulatory Genomics. [PMID: 12519946] Dieterich C, Wang H, Rateitschak K, Luz H, Vingron M. Abstract Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-'COmparative Regulatory Genomics'-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation. Nucleic Acids Res. 2003:31(1) \| 43 Citations (from Europe PMC, 2025-03-22)

Developments in CORG: a gene-centric comparative genomics resource. [PMID: 17135197]

Dieterich C, Franz MW, Vingron M.

The CORG resource (Comparative Regulatory Genomics, http://corg.eb.tuebingen.mpg.de) provides extensive cross-species comparisons of promoter regions in particular and whole gene loci in general. Pairwise as well as multiple alignments of 10 vertebrate species form the key component of CORG. We implemented a rapid alignment approach based on weight matrix motif anchors to ensure efficient computation and biologically informative alignments. All CORG workbench components have been enhanced towards more flexibility and interactivity. Reference sequence based data presentation and analysis was put into the well-known and modular Generic Genome Browser framework. Herein, various plugins facilitate online data analysis and integration with static conservation data. Main emphasis was put on the design of a new JAVA WebStart application for comparative data display. Flexible data import and export options for standard formats complete the provided services.

Nucleic Acids Res. 2007:35(Database issue) | 2 Citations (from Europe PMC, 2025-03-22)

CORG: a database for COmparative Regulatory Genomics. [PMID: 12519946]

Dieterich C, Wang H, Rateitschak K, Luz H, Vingron M.

Abstract

Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-'COmparative Regulatory Genomics'-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.

Nucleic Acids Res. 2003:31(1) | 43 Citations (from Europe PMC, 2025-03-22)

URL:	http://corg.eb.tuebingen.mpg.de
Full name:	Comparative Regulatory Genomics
Description:	The CORG resource provides extensive cross-species comparisons of promoter regions in particular and whole gene loci in general.
Year founded:	2003
Last update:
Version:
Accessibility:	Unaccessible
Country/Region:	Germany

Data type:	DNA
Data object:	Animal
Database category:	Gene genome and annotation
Major species:	NA
Keywords:	cross-species comparison promoter

University/Institution:	Max Planck Institute for Developmental Biology Spemannstrasse
Address:	35-37, 72076 Tübingen, Germany
City:	Tübingen
Province/State:
Country/Region:	Germany
Contact name (PI/Team):	C. Dieterich
Contact email (PI/Helpdesk):	christoph.dieterich@tuebingen.mpg.de

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Database Commons a catalog of worldwide biological databases