| URL: | http://sbrblood.nhgri.nih.gov |
| Full name: | Systems Biology Repository |
| Description: | SBR-Blood is a database, or more imaginative a data ranch, where data are curated/cultivated, repositories grown and analyses harvested. SBR-Blood contains next-generation sequencing and array-based data for different cell types in the hematopoietic stem-cell differentiation process. |
| Year founded: | 2016 |
| Last update: | 2015-11-20 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | United States |
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| University/Institution: | National Human Genome Research Institute |
| Address: | Bethesda, MD, USA |
| City: | Bethesda |
| Province/State: | MD |
| Country/Region: | United States |
| Contact name (PI/Team): | Jens Lichtenberg |
| Contact email (PI/Helpdesk): | lichtenbergj@mail.nih.gov |
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SBR-Blood: systems biology repository for hematopoietic cells. [PMID: 26590403]
Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository (SBR-Blood), available online at http://sbrblood.nhgri.nih.gov, which allows user-initiated analyses for cell type correlations or gene-specific behavior during differentiation using publicly available datasets for array- and sequencing-based platforms from mouse hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles. Published by Oxford University Press on behalf of Nucleic Acids Research 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. |