Hmrbase


37291365	Hmrbase2: a comprehensive database of hormones and their receptors. [PMID: 37291365] Dashleen Kaur, Akanksha Arora, Sumeet Patiyal, Gajendra Pal Singh Raghava Abstract PURPOSE: Hormones play a critical role in regulating various physiological processes and any hormonal imbalances can lead to major endocrine disorders. Thus, studying hormones is essential for both the therapeutics and the diagnostics of hormonal diseases. To facilitate this need, we have developed Hmrbase2, a comprehensive platform that provides extensive information on hormones. METHODS: Hmrbase2 is a web-based database which is an update of a previously published database, Hmrbase ( http://crdd.osdd.net/raghava/hmrbase/ ). We collected a large amount of information on peptide and non-peptide hormones and hormone receptors, this information being sourced from Hmrbase, HMDB, UniProt, HORDB, ENDONET, PubChem, and the medical literature. RESULTS: Hmrbase2 contains a total of 12,056 entries, which is more than twice the number of entries contained in the previous version Hmrbase. These include 7406, 753, and 3897 entries for peptide hormones, non-peptide hormones, and hormone receptors, respectively, from 803 organisms compared to the 562 organisms in the previous version. The database also hosts 5662 hormone receptor pairs. The source organism, function, and subcellular location are provided for peptide hormones and receptors and properties such as melting point and water solubility is provided for non-peptide hormones. Besides browsing and keyword search, an advanced search option has also been supplied. Additionally, a similarity search module has been incorporated enabling users to run similarity searches against peptide hormone sequences using BLAST and Smith-Waterman. CONCLUSIONS: To make the database accessible to various users, we designed a user-friendly, responsive website that can be easily used on smartphones, tablets, and desktop computers. The updated database version, Hmrbase2, offers improved data content compared to the previous version. Hmrbase2 is freely available at https://webs.iiitd.edu.in/raghava/hmrbase2 . Hormones (Athens). 2023:() \| 2 Citations (from Europe PMC, 2025-03-22)
19589147	Hmrbase: a database of hormones and their receptors. [PMID: 19589147] Rashid M, Singla D, Sharma A, Kumar M, Raghava GP. Abstract BACKGROUND: Hormones are signaling molecules that play vital roles in various life processes, like growth and differentiation, physiology, and reproduction. These molecules are mostly secreted by endocrine glands, and transported to target organs through the bloodstream. Deficient, or excessive, levels of hormones are associated with several diseases such as cancer, osteoporosis, diabetes etc. Thus, it is important to collect and compile information about hormones and their receptors. DESCRIPTION: This manuscript describes a database called Hmrbase which has been developed for managing information about hormones and their receptors. It is a highly curated database for which information has been collected from the literature and the public databases. The current version of Hmrbase contains comprehensive information about approximately 2000 hormones, e.g., about their function, source organism, receptors, mature sequences, structures etc. Hmrbase also contains information about approximately 3000 hormone receptors, in terms of amino acid sequences, subcellular localizations, ligands, and post-translational modifications etc. One of the major features of this database is that it provides data about approximately 4100 hormone-receptor pairs. A number of online tools have been integrated into the database, to provide the facilities like keyword search, structure-based search, mapping of a given peptide(s) on the hormone/receptor sequence, sequence similarity search. This database also provides a number of external links to other resources/databases in order to help in the retrieving of further related information. CONCLUSION: Owing to the high impact of endocrine research in the biomedical sciences, the Hmrbase could become a leading data portal for researchers. The salient features of Hmrbase are hormone-receptor pair-related information, mapping of peptide stretches on the protein sequences of hormones and receptors, Pfam domain annotations, categorical browsing options, online data submission, DrugPedia linkage etc. Hmrbase is available online for public from http://crdd.osdd.net/raghava/hmrbase/. BMC Genomics. 2009:10() \| 15 Citations (from Europe PMC, 2025-03-22)

Hmrbase2: a comprehensive database of hormones and their receptors. [PMID: 37291365]

Dashleen Kaur, Akanksha Arora, Sumeet Patiyal, Gajendra Pal Singh Raghava

PURPOSE: Hormones play a critical role in regulating various physiological processes and any hormonal imbalances can lead to major endocrine disorders. Thus, studying hormones is essential for both the therapeutics and the diagnostics of hormonal diseases. To facilitate this need, we have developed Hmrbase2, a comprehensive platform that provides extensive information on hormones.
METHODS: Hmrbase2 is a web-based database which is an update of a previously published database, Hmrbase ( http://crdd.osdd.net/raghava/hmrbase/ ). We collected a large amount of information on peptide and non-peptide hormones and hormone receptors, this information being sourced from Hmrbase, HMDB, UniProt, HORDB, ENDONET, PubChem, and the medical literature.
RESULTS: Hmrbase2 contains a total of 12,056 entries, which is more than twice the number of entries contained in the previous version Hmrbase. These include 7406, 753, and 3897 entries for peptide hormones, non-peptide hormones, and hormone receptors, respectively, from 803 organisms compared to the 562 organisms in the previous version. The database also hosts 5662 hormone receptor pairs. The source organism, function, and subcellular location are provided for peptide hormones and receptors and properties such as melting point and water solubility is provided for non-peptide hormones. Besides browsing and keyword search, an advanced search option has also been supplied. Additionally, a similarity search module has been incorporated enabling users to run similarity searches against peptide hormone sequences using BLAST and Smith-Waterman.
CONCLUSIONS: To make the database accessible to various users, we designed a user-friendly, responsive website that can be easily used on smartphones, tablets, and desktop computers. The updated database version, Hmrbase2, offers improved data content compared to the previous version. Hmrbase2 is freely available at https://webs.iiitd.edu.in/raghava/hmrbase2 .

Hormones (Athens). 2023:() | 2 Citations (from Europe PMC, 2025-03-22)

Hmrbase: a database of hormones and their receptors. [PMID: 19589147]

Rashid M, Singla D, Sharma A, Kumar M, Raghava GP.

Abstract

BACKGROUND: Hormones are signaling molecules that play vital roles in various life processes, like growth and differentiation, physiology, and reproduction. These molecules are mostly secreted by endocrine glands, and transported to target organs through the bloodstream. Deficient, or excessive, levels of hormones are associated with several diseases such as cancer, osteoporosis, diabetes etc. Thus, it is important to collect and compile information about hormones and their receptors.
DESCRIPTION: This manuscript describes a database called Hmrbase which has been developed for managing information about hormones and their receptors. It is a highly curated database for which information has been collected from the literature and the public databases. The current version of Hmrbase contains comprehensive information about approximately 2000 hormones, e.g., about their function, source organism, receptors, mature sequences, structures etc. Hmrbase also contains information about approximately 3000 hormone receptors, in terms of amino acid sequences, subcellular localizations, ligands, and post-translational modifications etc. One of the major features of this database is that it provides data about approximately 4100 hormone-receptor pairs. A number of online tools have been integrated into the database, to provide the facilities like keyword search, structure-based search, mapping of a given peptide(s) on the hormone/receptor sequence, sequence similarity search. This database also provides a number of external links to other resources/databases in order to help in the retrieving of further related information.
CONCLUSION: Owing to the high impact of endocrine research in the biomedical sciences, the Hmrbase could become a leading data portal for researchers. The salient features of Hmrbase are hormone-receptor pair-related information, mapping of peptide stretches on the protein sequences of hormones and receptors, Pfam domain annotations, categorical browsing options, online data submission, DrugPedia linkage etc. Hmrbase is available online for public from http://crdd.osdd.net/raghava/hmrbase/.

BMC Genomics. 2009:10() | 15 Citations (from Europe PMC, 2025-03-22)

URL:	http://crdd.osdd.net/raghava/hmrbase
Full name:	a database of hormones and their receptors
Description:	HMRbase is a manually curated database of Hormones and their Receptors. It is a compilation of sequence data after extensive manual literature search and from publicly available databases.
Year founded:	2009
Last update:
Version:
Accessibility:	Accessible
Country/Region:	India

Data type:	Protein
Data object:	Animal
Database category:	Health and medicine Interaction Literature
Major species:	Homo sapiens
Keywords:	hormones receptors

University/Institution:	Institute of Microbial Technology
Address:
City:
Province/State:
Country/Region:	India
Contact name (PI/Team):	Gajendra P. S. Raghava
Contact email (PI/Helpdesk):	raghava@iiitd.ac.in

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Database Commons a catalog of worldwide biological databases