| URL: | http://gametsepi.nwsuaflmz.com |
| Full name: | Gametogenesis Epigenetic Database |
| Description: | This is a literature information resources database for mammalian gametogenesis with the effects of epigenetic modification. We integrated the epigenetic modification information of mammal gametogenesis from more than a thousand literatures, and predicted the potential pathway during each gametogenesis phase in mammals. The literatures were downloaded from PubMed and related to seven species which including human, mouse, rat, cattle, pig, sheep, goat and sixteen gametogenesis phase which including PGC, gonocyte, oogonium, oocyte, primary oocyte, secondary oocyte, ootid, ovum, spermatogonium, spermatocyte, type A spermatogonium, type B spermatogonium, primary spermatocyte, secondary spermatocyte, spermatid, sperm. |
| Year founded: | 2017 |
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| Country/Region: | China |
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| University/Institution: | Northwest A&F University |
| Address: | College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China. |
| City: | Xianyang |
| Province/State: | Shanxi2 |
| Country/Region: | China |
| Contact name (PI/Team): | Mingzhi Liao |
| Contact email (PI/Helpdesk): | liaomingzhi83@163.com |
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GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis. [PMID: 26851225]
Reproductive infertility affects seventh of couples, which is most attributed to the obstacle of gametogenesis. Characterizing the epigenetic modification factors involved in gametogenesis is fundamental to understand the molecular mechanisms and to develop treatments for human infertility. Although the genetic factors have been implicated in gametogenesis, no dedicated bioinformatics resource for gametogenesis is available. To elucidate the relationship of epigenetic modification and mammalian gametogenesis, we developed a new database, gametogenesis epigenetic modification database (GED), a manually curated database, which aims at providing a comprehensive resource of epigenetic modification of gametogenesis. The database integrates three kinds information of epigenetic modifications during gametogenesis (DNA methylation, histone modification and RNA regulation), and the gametogenesis has been detailed as 16 stages in seven mammal species (Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Bos taurus, Capra hircus and Ovis aries). Besides, we have predicted the linear pathways of epigenetic modification which were composed of 211 genes/proteins and microRNAs that were involved in gametogenesis. GED is a user-friendly Web site, through which users can obtain the comprehensive epigenetic factor information and molecular pathways by visiting our database freely. GED is free available at http://gametsepi.nwsuaflmz.com. |