Pancreatic Cancer Database


24839966	Pancreatic Cancer Database: an integrative resource for pancreatic cancer. [PMID: 24839966] Thomas JK, Kim MS, Balakrishnan L, Nanjappa V, Raju R, Marimuthu A, Radhakrishnan A, Muthusamy B, Khan AA, Sakamuri S, Tankala SG, Singal M, Nair B, Sirdeshmukh R, Chatterjee A, Prasad TS, Maitra A, Gowda H, Hruban RH, Pandey A. Abstract Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research. Cancer Biol Ther. 2014:15(8) \| 38 Citations (from Europe PMC, 2025-03-29)
21519797	Screening for serological biomarkers of pancreatic cancer by two-dimensional electrophoresis and liquid chromatography-tandem mass spectrometry. [PMID: 21519797] Wang Y, Kuramitsu Y, Yoshino S, Takashima M, Zhang X, Ueno T, Suzuki N, Oka M, Nakamura K. Abstract Pancreatic cancer (PC) is one of the most lethal malignant tumors because of late diagnosis and the lack of response to various therapies. To identify potential biomarkers in cancerous serum from early stage PC patients, we carried out two-dimensional gel electrophoresis (2-DE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to compare the serum proteomic profiles from 45 patients with PC and 20 healthy volunteers. Seven spots showed differential expression on 2-DE gels and two up-regulated protein spots were identified by LC-MS/MS as ?-1-antitrypsin (AAT). These protein spots were also confirmed by Western blotting. This is the first time that AAT isoforms have been identified as potential serum biomarkers for PC. The serum isoforms of AAT may be clinically useful for PC diagnosis and monitoring. Oncol Rep. 2011:26(1) \| 7 Citations (from Europe PMC, 2025-03-29)

Pancreatic Cancer Database: an integrative resource for pancreatic cancer. [PMID: 24839966]

Thomas JK, Kim MS, Balakrishnan L, Nanjappa V, Raju R, Marimuthu A, Radhakrishnan A, Muthusamy B, Khan AA, Sakamuri S, Tankala SG, Singal M, Nair B, Sirdeshmukh R, Chatterjee A, Prasad TS, Maitra A, Gowda H, Hruban RH, Pandey A.

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.

Cancer Biol Ther. 2014:15(8) | 38 Citations (from Europe PMC, 2025-03-29)

Screening for serological biomarkers of pancreatic cancer by two-dimensional electrophoresis and liquid chromatography-tandem mass spectrometry. [PMID: 21519797]

Wang Y, Kuramitsu Y, Yoshino S, Takashima M, Zhang X, Ueno T, Suzuki N, Oka M, Nakamura K.

Abstract

Pancreatic cancer (PC) is one of the most lethal malignant tumors because of late diagnosis and the lack of response to various therapies. To identify potential biomarkers in cancerous serum from early stage PC patients, we carried out two-dimensional gel electrophoresis (2-DE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to compare the serum proteomic profiles from 45 patients with PC and 20 healthy volunteers. Seven spots showed differential expression on 2-DE gels and two up-regulated protein spots were identified by LC-MS/MS as ?-1-antitrypsin (AAT). These protein spots were also confirmed by Western blotting. This is the first time that AAT isoforms have been identified as potential serum biomarkers for PC. The serum isoforms of AAT may be clinically useful for PC diagnosis and monitoring.

Oncol Rep. 2011:26(1) | 7 Citations (from Europe PMC, 2025-03-29)

URL:	http://www.pancreaticcancerdatabase.org
Full name:	Pancreatic Cancer Database
Description:	The Pancreatic Cancer Database is a resource of experimentally demonstrated molecular alterations associated with pancreatic cancer in cancer tissues or cancer cell lines. It currently contains information pertaining to changes at the mRNA, protein and miRNA levels. The data can be queried or browsed at mRNA, protein or miRNA levels or based on specific cancer subtypes. Individual entries are also linked to Entrez Gene, OMIM, Human Protein Reference Database (HPRD), HGNC and miRBase.
Year founded:	2011
Last update:
Version:
Accessibility:	Accessible
Country/Region:	United States

Data type:	DNA Protein RNA
Data object:	Animal
Database category:	Health and medicine
Major species:	Homo sapiens
Keywords:	Cancer

University/Institution:	Johns Hopkins University
Address:	McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Biological Chemistry; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Pathology; Sol Goldman Pancreatic Cancer Research Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA
City:
Province/State:
Country/Region:	United States
Contact name (PI/Team):	Akhilesh Pandey
Contact email (PI/Helpdesk):	pandey@jhmi.edu

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Database Commons a catalog of worldwide biological databases

a catalog of worldwide biological databases

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